Computational Design in Synthetic Biology

  • Maria Suarez
  • Guillermo Rodrigo
  • Javier Carrera
  • Alfonso Jaramillo


One of the most ambitious goals in biological engineering is the ability to computationally design an organism using unsupervised algorithms. We discuss the development of new automatic methodologies to design biological parts and devices using computational design. Some of them rely on the appropriate characterisation of single genetic elements into SBML models and their posterior assembly to generate the final transcriptional network with targeted behaviour (such as an oscillatory dynamics). This modular construction approach allows implementing a successful modelling-construction-characterization cycle. Currently, it is not clear what role is played by cellular context, and to which extent it is possible to fruitfully use such a modular approach, but the perspectives of a model-based design of biological networks overwhelms the corresponding risk.


Synthetic Biology Genetic Network Biological Part Genetic Circuit Synthetic Biologist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Spanish Ministry of Education and Science (ref. TIN 2006-12860), the Structural Funds of the European Regional Development Fund (ERDF), the EU grants BioModularH2 (FP6-NEST contract 043340) and EMERGENCE (FP6-NEST contract 043338) and the ATIGE Genopole/UEVE CR-A3405. GR acknowledges a graduate fellowship from the Conselleria d’Educacio de la Generalitat Valenciana (ref. BFPI 2007/160) and an EMBO Short-term fellowship (ref. ASTF-343.00-2007).


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Maria Suarez
    • 1
    • 2
  • Guillermo Rodrigo
    • 3
  • Javier Carrera
    • 3
    • 4
  • Alfonso Jaramillo
    • 1
    • 2
  1. 1.Lab BiochimieEcole PolytechniquePalaiseauFrance
  2. 2.Epigenomics ProjectGenopoleEvry CedexFrance
  3. 3.Institute of Biologia Molecular y Celular de Plantas, CSIC-UPVValenciaSpain
  4. 4.Institute of Aplic. en Tecnologias de la Informacion y las Comunicaciones Avanzadas, UPVValenciaSpain

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