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The Frontiers of Computational Phenomics in Cancer Research

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An Omics Perspective on Cancer Research

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Abstract

Understanding the molecular mechanisms underpinning prognosis and response to therapy of individuals suffering from cancer increasingly requires integrated and systematic approaches. Molecular-based strategies to more effectively prevent, diagnose, and treat cancer are seen as the future goal of oncology research. Although altered phenotypes can reliably be associated with altered gene functions, the systematic analysis of phenotypes relationships to study cancer biology remains nascent. The completion of the Human Genome Project has made possible high-throughput approaches such as the Cancer Genome Atlas to accelerate phenomics research. However, these approaches still face important challenges. In this chapter, we review these challenges, introduce current research efforts in the field, and highlight the importance of computational approaches to conduct large-scale phenomic studies.

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Acknowledgements

This work was supported in part by the 1U54CA121852 (National Center for Multiscale Analyses of Genomic and Cellular Networks - MAGNET), the Cancer Research Foundation, the University of Chicago Cancer Research Center and the Ludwig Center for Metastasis Research.

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Authors and Affiliations

  1. Section of Hematology/Oncology and Stem Cell Transplantation, Department of Pediatrics, and Computation Institute, The University of Chicago, Chicago, IL, USA

    Eneida A. Mendonça

  2. Section of Genetic Medicine, Department of Medicine, Ludwig Center for Metastasis Research, Institute for Genomics and Systems Biology, Computation Institute, and Cancer Research Center, The University of Chicago, Chicago, IL, USA

    Yves A. Lussier

Authors
  1. Eneida A. Mendonça
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  2. Yves A. Lussier
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Correspondence to Eneida A. Mendonça .

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Editors and Affiliations

  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong/PR China

    William C.S. Cho

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Mendonça, E.A., Lussier, Y.A. (2010). The Frontiers of Computational Phenomics in Cancer Research. In: Cho, W. (eds) An Omics Perspective on Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2675-0_11

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