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Cell Cycle Regulation and DNA Damage

  • Ryo SakasaiEmail author
  • Randal S. Tibbetts
Chapter

Abstract

Regulation of the cell cycle is perhaps the best-understood facet of the DNA damage. DNA damage signals generated downstream of the apical DNA damage signaling kinases ATM and ATR lead to transient checkpoints in the cell cycle at the G1/S and G2/M boundaries, as well as transient inhibition of DNA replication. The focus of this review is to highlight the current understanding and established principles of DNA damage-dependent cell cycle regulation, including the roles of protein phosphorylation/dephosphorylation, and regulated protein degradation. The DNA damage-cell cycle paradigm has broad implications for understanding genomic instability, cancer susceptibility, and neurodegenerative disease.

Keywords

Cell cycle Checkpoint DNA damage Mitosis Cyclin Cyclin-dependent kinase Anaphase-promoting complex Ubiquitin Proteasome Ataxia-telangiectasia Cancer ATM ATR CHEK2 CHEK1 CDC25 Tumor suppressor DNA replication Genetic instability 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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