The influence of weed control on fertilizer nitrogen use efficiencies (NUEs) by rice genotypes was studied in the Senegal River valley of West Africa with a field experiment during four rice growing seasons. It was hypothesized that integrated management of technologies could improve rice productivity. The objective was to develop integrated high-return technologies that improve irrigated rice-based systems productivity and profitability. Data indicated that rice grain yields were affected by N fertilizer, genotypes and plant densities. In good weed control conditions, optimum doses of recommended N fertilizer varied from 80 to 180 kg N ha–1. Fertilizer N use efficiencies by genotypes were affected by weed control. Profitable management options of genotypes and N fertilizer recommendations have been identified. With a good control of weed, varieties and N fertilizer recommendations were suggested as integrated management options for farmers. But poor control of weed increased N lost, decreased grain yields and profitability. Two genotypes (WAS 55-B-B-2-1-2-5 and WAS 191-1-1-7 FKR) were found to be most competitive against weeds. However, no more than 60 kg N ha–1 should ever be recommended when weeds are poorly controlled. It was concluded that productivity and profitability of irrigated rice-based systems could be improved with integrated management options of genotypes, fertilizers and weed.