Abstract
Invasive aspergillosis was previously considered an AIDS-defining disease. However, this infection is seen only occasionally in HIV-infected patients, usually affecting patients with advanced disease. The most commonly implicated factors for invasive aspergillosis are neutropenia, granulocyte dysfunction, exposure to broad-spectrum antibacterial therapy and a long term steroid use. The diagnosis of invasive pulmonary aspergillosis is hampered by the absence of typical clinic-radiological findings. New diagnostic tests such as galactomannan testing are of limited utility for AIDS patients. Cerebral aspergillosis seems to be more prevalent in the HIV population than in other groups. Treatment of invasive aspergillosis in the context of HIV infection is similar to treatment in patients not infected with the HIV, though special attention is required for drug-drug interactions.
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References
Kaplan, J. E., Benson, C. A., Holmes, K. K. Pau, A. & Masur, H., (2009) Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. MMWR Recomm Rep, 58, 1–207.
Denning, D. W., Follansbee, S. E., Scolaro, M., Norris, S., Edelstein, H. & Stevens, D. A. (1991) Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med, 324, 654–62.
Khoo, S. H. & Denning, D. W. (1994) Invasive aspergillosis in patients with AIDS. Clin Infect Dis, 19 Suppl 1, S41–8.
Holding, K. J., Dworkin, M. S., Wan, P. C., Hanson, D. L., Klevens, R. M., Jones, J. L. & Sullivan, P. S. (2000) Aspergillosis among people infected with human immunodeficiency virus: incidence and survival. Adult and Adolescent Spectrum of HIV Disease Project. Clin Infect Dis, 31, 1253–57.
Mylonakis, E., Barlam, T. F., Flanigan, T. & Rich, J. D. (1998) Pulmonary aspergillosis and invasive disease in AIDS: review of 342 cases. Chest, 114, 251–62.
Fairley, C. K., Kent, S. J., Street, A., Mijch, A. & Hoy, J. (1991) Invasive aspergillosis in AIDS. Aust N Z J Med, 21, 747–9.
Lortholary, O., Meyohas, M. C., Dupont, B., Cadranel, J., Salmon-Ceron, D., Peyramond, D. & Simonin, D. (1993) Invasive aspergillosis in patients with acquired immunodeficiency syndrome: report of 33 cases. French Cooperative Study Group on Aspergillosis in AIDS. Am J Med, 95, 177–87.
Petrosillo, N., Pellicelli, A. M., Cicalini, S., Conte, A., Goletti, D. & Palmieri, F. (2001) Endocarditis caused by Aspergillus species in injection drug users. Clin Infect Dis, 33, e97–9.
Shetty, D., Giri, N., Gonzalez, C. E., Pizzo, P. A. & Walsh, T. J. (1997) Invasive aspergillosis in human immunodeficiency virus-infected children. Pediatr Infect Dis J, 16, 216–21.
Singh, N., Yu, V. L. & Rihs, J. D. (1991) Invasive aspergillosis in AIDS. South Med J, 84, 822–27.
Tumbarello, M., Ventura, G., Caldarola, G., Morace, G., Cauda, R. & Ortona, L. (1993) An emerging opportunistic infection in HIV patients: a retrospective analysis of 11 cases of pulmonary aspergillosis. Eur J Epidemiol, 9, 638–44.
Wallace, M. R., Kanak, R. J., Newton, J. A. & Kennedy, C. A. (1994) Invasive aspergillosis in patients with AIDS. Clin Infect Dis, 19, 222.
Wright, M., Fikrig, S. & Haller, J. O. (1993) Aspergillosis in children with acquired immune deficiency. Pediatr Radiol, 23, 492–94.
Denning, D. W. (1998) Invasive aspergillosis. Clin Infect Dis, 26, 781–803; quiz 4–5.
Keating, J. J., Rogers, T., Petrou, M., Cartledge, J. D., Woodrow, D., Nelson, M., Hawkins, D. A. & Gazzard, B. G. (1994) Management of pulmonary aspergillosis in AIDS: an emerging clinical problem. J Clin Pathol, 47, 805–9.
Rolston, K. V. & Rodriguez, S. (1991) Pulmonary aspergillosis in AIDS. N Engl J Med, 325, 356.
Libanore, M., Prini, E., Mazzetti, M., Barchi, E., Raise, E., Gritti, F. M., Bonazzi, L. & Ghinelli, F. (2002) Invasive Aspergillosis in Italian AIDS patients. Infection, 30, 341–45.
Moreno, A., Perez-Elias, M., Casado, J., Navas, E., Pintado, V., Fortun, J., Quereda, C. & Guerrero, A. (2000) Role of antiretroviral therapy in long-term survival of patients with AIDS-related pulmonary aspergillosis. Eur J Clin Microbiol Infect Dis, 19, 688–93.
Klapholz, A., Salomon, N., Perlman, D. C. & Talavera, W. (1991) Aspergillosis in the acquired immunodeficiency syndrome. Chest, 100, 1614–18.
Minamoto, G. Y., Barlam, T. F. & Vander Els, N. J. (1992) Invasive aspergillosis in patients with AIDS. Clin Infect Dis, 14, 66–74.
Cohen, J. (1991) Clinical manifestation and management of aspergillosis in the compromised patients. in Warnock, D. W. & Richardson, M. D., Editors., Fungal infection in the compromised patient, John Wiley: New York, USA. pp. 118–652.
Denning, D. W. (1996) Diagnosis and management of invasive aspergillosis. Curr Clin Top Infect Dis, 16, 277–99.
Zaspel, U., Denning, D. W., Lemke, A. J., Greene, R., Schurmann, D., Maschmeyer, G., Ruhnke, M., Herbrecht, R., Ribaud, P., Lortholary, O., Zonderland, H., Rabe, K. F., Rottgen, R., Bittner, R., Neumann, K. & Oestmann, J. W. (2004) Diagnosis of IPA in HIV: the role of the chest X-ray and radiologist. Eur Radiol, 14, 2030–7.
Sambatakou, H. & Denning, D. W. (2005) Invasive pulmonary aspergillosis transformed into fatal mucous impaction by immune reconstitution in an AIDS patient. Eur J Clin Microbiol Infect Dis, 24, 628–33.
Aquino, V. R., Goldani, L. Z. & Pasqualotto, A. C. (2007) Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis. Mycopathologia, 163, 191–202.
Xavier, M. O., Pasqualotto, A. C., Cardoso, I. C. & Severo, L. C. (2008) Cross-reactivity of Paracoccidioides brasiliensis, Histoplasma capsulatum, and Cryptococcus species in the commercial kit Platelia Aspergillus EIA. Clin Vaccine Immunol.
Walsh, T. J., Anaissie, E. J., Denning, D. W., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Segal, B. H., Steinbach, W. J., Stevens, D. A., Van Burik, J. A., Wingard, J. R. & Patterson, T. F. (2008) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis, 46, 327–60.
Schwartz, S., Ruhnke, M., Ribaud, P., Corey, L., Driscoll, T., Cornely, O. A., Schuler, U., Lutsar, I., Troke, P. & Thiel, E. (2005) Improved outcome in central nervous system aspergillosis, using voriconazole treatment. Blood, 106, 2641–5.
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Libanore, M., Sighinolfi, L., Ghinelli, F. (2009). Invasive Aspergillosis and HIV Infection. In: Comarú Pasqualotto, A. (eds) Aspergillosis: From Diagnosis to Prevention. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2408-4_33
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DOI: https://doi.org/10.1007/978-90-481-2408-4_33
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