Genetics of Mood Disorders

  • Laura Mandelli
  • Alessandra Nivoli
  • Alessandro Serretti

Mood disorders are common diseases of major public health importance, contributing to 11% of all inabilities worldwide. Genetic factors are known to play an important role in infl uencing susceptibility to Mood disorders: indeed, formal genetic studies suggest that the risk for first-degree relatives of an affected proband is about threefold higher than the overall population for Major depressive disorder and tenfold higher for bipolar disorder. In the last years, molecular genetic studies provided an extremely large number of findings, even if often confl icting and not consistent. After a brief methodological introduction about genetic study designs, the current knowledge derived from research on mood disorders will be reviewed, particularly as regards genomic regions of interest and genes probably involved in such diseases. Indeed, some chromosomal areas have been repeatedly associated to mood disorders, as well as some interesting genes have been tested. Other genes have received promising evidence and further research is thus needed in order to establish their involvement in mood diseases. Finally, a brief discussion will be focused on the utility to employ more complex research designs in order to disentangle confl icting findings. Mood disorders are complex and heterogeneous disorders, thus gene—gene, gene—environment interactions and endo-phenotypes investigations will probably produce more robust findings.


Bipolar disorder depression gene pharmacogenetics phenotype 


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  1. 1.
    American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Revised. Washington DC: American Psychiatric Association, 2002.Google Scholar
  2. 2.
    World Health Organization. The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). 1992.Google Scholar
  3. 3.
    Craddock N, Forty L. Genetics of affective (mood) disorders. Eur J Hum Genet 2006; 14: 660–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Wittchen H-U, Jacobi F. Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 2005; 15: 357–76.PubMedCrossRefGoogle Scholar
  5. 5.
    Sobocki P, Lekander I, Borgstrom F, et al. The economic burden of depression in Sweden from 1997 to 2005. Eur Psychiatr 2007; 22: 146–52.CrossRefGoogle Scholar
  6. 6.
    Goodwin FK, Jamison KR. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd Edition. New York: Oxford University Press, 2007.Google Scholar
  7. 7.
    McGuffin P, Owen MJ, Gottesman II. Psychiatric Genetics and Genomics. USA: Oxford University Press, 2004.Google Scholar
  8. 8.
    Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatr 2000; 157: 1552–62.PubMedCrossRefGoogle Scholar
  9. 9.
    Levinson DF. The genetics of depression: a review. Biol Psychiatr 2006; 60: 84–92.CrossRefGoogle Scholar
  10. 10.
    Kelsoe JR, Spence MA, Loetscher E, et al. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci U S A 2001; 98: 585–90.PubMedCrossRefGoogle Scholar
  11. 11.
    Burmeister M. Basic concepts in the study of diseases with complex genetics. Biol Psychiatr 1999; 45: 522–32.CrossRefGoogle Scholar
  12. 12.
    Wellcome Trust CCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661–78.CrossRefGoogle Scholar
  13. 13.
    Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Serretti A, Calati R, Mandelli L, De Ronchi D. Serotonin transporter gene variants and behavior: a comprehensive review. Curr Drug Targets 2006; 7: 1659–69.PubMedCrossRefGoogle Scholar
  15. 15.
    Drago A, De Ronchi D, Serretti A. Incomplete coverage of candidate genes: a poorly considered bias. Current Genomics In Press.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Laura Mandelli
    • 1
  • Alessandra Nivoli
    • 2
  • Alessandro Serretti
    • 2
  1. 1.Assistant Professor of Psychiatry, Institute of PsychiatryUniversity of BolognaItaly
  2. 2.Associate Professor of Psychiatry, Institute of PsychiatryUniversity of SassariSassariItaly

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