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Rabbit Biotechnology pp 105–128Cite as

Rabbit Cloning

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Abstract

Rabbit somatic cell nuclear transfer (SCNT) offers new opportunities for basic research, biomedical and agricultural applications and genome preservation. However, the technology is still in a very early development stage and it is relatively inefficient proving many early expectations premature. The technical steps of SCNT are extremely complex. They are also very sensitive to small changes and fluctuations in technical parameters. Furthermore, the biological background of the reprogramming process is not fully understood. It makes it virtually impossible to optimize a protocol providing “ideal” recipient oocytes and donor cells for the process. In this chapter we will intend to summarize the current status of nuclear transfer technology in rabbits and to give the readers a brief insight of its future use.

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Bibliography

  • Adams, C. E. (1958) Egg development in the rabbit. The influence of post-coital ligation on the uterine tube and ovariectomy. J. Endocrinol. 16: 283–294.

    Article  PubMed  CAS  Google Scholar 

  • Adams, C. E. (1960) Prenatal mortality in the rabbit Oryctolagus cuniculus. J. Reprod. Fertil. 1: 36–44.

    PubMed  CAS  Google Scholar 

  • Adams, C. E. (1970) Maintenance of pregnancy relative to the presence of few embryos in the rabbit. J. Endocrinol. 48: 243–249.

    Article  PubMed  CAS  Google Scholar 

  • Adams, C. E., Hay, M. F., and Lutwak-Mann, C. (1961) The action of various agents upon the rabbit embryo. J. Embryol. Exp. Morphol. 9: 468–491.

    PubMed  CAS  Google Scholar 

  • Adenot, P.G., Szöllösi, M. S., Chesné, P., Chastant, S., and Renard J. P. (1997) In vivo aging of oocytes influences the behavior of nuclei transferred to enucleated rabbit oocytes. Mol. Reprod. Dev. 46(3): 325–336.

    Article  PubMed  CAS  Google Scholar 

  • al-Hasani, S., Kirsch, J., Diedrich, K., Blanke, S., van, d., V, and Krebs, D. (1989) Successful embryo transfer of cryopreserved and in-vitro fertilized rabbit oocytes. Hum. Reprod. 4: 77–79.

    PubMed  CAS  Google Scholar 

  • Anderson, J. and Henck, J. W. (1994) Toxicity and Safety Testing. In“The Biology of the Laboratory Rabbit” (Manning, P. J., Ringler, D. H., and Newcomer, C. E., Eds.), pp. 455–466, Academic, San Diego, CA.

    Google Scholar 

  • Baguisi, A., Behboodi, E., Melican, D. T., Pollock, J. S., Destrempes, M. M., Cammuso, C., Williams, J. L., Nims, S. D., Porter, C. A., Midura, P., Palacios, M. J., Ayres, S. L., Denniston, R. S., Hayes, M. L., Ziomek, C. A., Meade, H. M., Godke, R. A., Gavin, W. G., Overstrom, E. W., and Echelard, Y. (1999) Production of goats by somatic cell nuclear transfer. Nat. Biotechnol. 17: 456–461.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, F. L. and Eyestone, W. H. (1990) Early cleavage and the maternal zygotic transition in bovine embryos. Theriogenology 33: 141–152.

    Article  Google Scholar 

  • Barnes, F. L., Collas, P., Powell, R., King, W. A., Westhusin, M., and Shepherd, D. (1993) Influence of recipient oocyte cell cycle stage on DNA synthesis, nuclear envelope breakdown, chromosome constitution, and development in nuclear transplant bovine embryos. Mol. Reprod. Dev. 36: 33–41.

    Article  PubMed  CAS  Google Scholar 

  • Beatty, R. A. (1958) Variation in the number of crpora lutea and in the number and size of 6-day blastocysts in rabbits subjected to superovulation treatment. J. Endocrinol. 17: 248–260.

    Article  PubMed  CAS  Google Scholar 

  • Besenfelder, U. and Brem, G. (1993) Laparoscopic embryo transfer in rabbits. J. Reprod. Fertil. 99: 53–56.

    PubMed  CAS  Google Scholar 

  • Besenfelder, U., Strouhal, C., and Brem, G. (1998) A method for endoscopic embryo collection and transfer in the rabbit. Zentralbl. Veterinarmed. A 45: 577–579.

    PubMed  CAS  Google Scholar 

  • Betthauser, J., Forsberg, E., Augenstein, M., Childs, L., Eilertsen, K., Enos, J., Forsythe, T., Golueke, P., Jurgella, G., Koppang, R., Lesmeister, T., Mallon, K., Mell, G., Misica, P., Pace, M., Pfister-Genskow, M., Strelchenko, N., Voelker, G., Watt, S., Thompson, S., and Bishop, M. (2000) Production of cloned pigs from in vitro systems. Nat. Biotechnol. 18: 1055–1059.

    Article  PubMed  CAS  Google Scholar 

  • Boquest, A. C., Day, B. N., and Prather, R. S. (1999) Flow cytometric cell cycle analysis of cultured porcine fetal fibroblast cells. Bio. Reprod. 60: 1013–1019.

    Article  CAS  Google Scholar 

  • Brophy, B., Smolenski, G., Wheeler, T., Wells, D., L'Huillier, P., Laible, G. (2003) Cloned trans-genic cattle produce milk with higher levels of ß-casein and? -casein. Nat. Biotechnol. 21: 157–162.

    Article  PubMed  CAS  Google Scholar 

  • Brunet-Simon, A., Henrion, G., Renard, J. P., and Duranthon, V. (2001) Onset of zygotic transcription and maternal transcript legacy in the rabbit embryo. Mol. Reprod. Dev. 58: 127–136.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, K. H., Loi, P., Otaegui, P. J., and Wilmut, I. (1996) Cell cycle co-ordination in embryo cloning by nuclear transfer. Rev. Reprod. 1: 40–46.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, K. H. S., McWhir, J., Ritchie, W. A., and Wilmut, I. (1996) Sheep cloned by nuclear transfer from a cultured cell line. Nature 380: 64–66.

    Article  PubMed  CAS  Google Scholar 

  • Capecchi, M. (2000) How close are we to implementing gene targeting in animals other than the mouse. Proc. Natl. Acad. Sci. USA 97: 956–957.

    Article  PubMed  CAS  Google Scholar 

  • Carney, E. W. and Foote, R. H. (1990) Effects of superovulation, embryo recovery, culture system and embryo transfer on development of rabbit embryos in vivo and in vitro. J. Reprod. Fertil. 89: 543–551.

    Article  PubMed  CAS  Google Scholar 

  • Carney, E. W. and Foote, R. H. (1991) Improved development of rabbit one-cell embryos to the hatching blastocyst stage by culture in a defined, protein-free culture medium. J. Reprod. Fertil. 91: 113–123.

    PubMed  CAS  Google Scholar 

  • Carney, E. W., Tobback, C., Ellington, J. E., and Foote, R. H. (1990) Co-culture of rabbit 2-cell embryos with rabbit oviduct epithelial cells and other somatic cells. Mol. Reprod. Dev. 27: 209–215.

    Article  PubMed  CAS  Google Scholar 

  • Cervera, R. P. and García-Ximénez, F. (2003) Oocyte age and nuclear donor cell type affect the technical efficiency of somatic cloning in rabbits. Zygote 11(2): 151–158

    Article  PubMed  CAS  Google Scholar 

  • Challah-Jacques, M., Chesne, P., and Renard, J. P. (2003). Production of Cloned Rabbits by Somatic Nuclear Transfer. Cloning Stem Cells. 5: 295–299

    Article  PubMed  CAS  Google Scholar 

  • Chang, M. C. (1951) Fertilization capacity of sperm deposited in the fallopian tube. Nat. (Lond.) 168: 697.

    Article  CAS  Google Scholar 

  • Chang, M. C., Casas, J. H., and Hunt, D. M. (1971) Development of ferret eggs after 2 to 3 days in the rabbit fallopian tube. J. Reprod. Fertil. 25: 129–131.

    PubMed  CAS  Google Scholar 

  • Chen, T., Zhang, Y. L., Jiang, Y., Liu, S. Z., Schatten, H., Chen, D. Y., and Sun, Q. Y. (2004) The DNA methylation events in normal and cloned rabbit embryos. FEBS Lett. 578: 69–72.

    Article  PubMed  CAS  Google Scholar 

  • Chen, T., Zhang, Y. L., Jiang, Y., Liu, J. H., Schatten, H., Chen, D. Y., and Sun, Q. Y. (2006) Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos. Mol. Reprod. Dev. 73(3): 313–317.

    Article  PubMed  CAS  Google Scholar 

  • Chen, Y., He, Z. X., Liu, A., Wang, K., Mao, W. W., Chu, J. X., Lu, Y., Fang, Z. F., Shi, Y. T., Yang, Q. Z., Chen da, Y., Wang, M. K., Li, J. S., Huang, S. L., Kong, X. Y., Shi, Y. Z., Wang, Z. Q., Xia, J. H., Long, Z. G., Xue, Z. G., Ding, W. X., and Sheng, H. Z. (2003) Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes. Cell Res. 13(4): 251–256

    Article  PubMed  Google Scholar 

  • Chesné, P., Adenot, P., Boulanger, L., and Renard, J. P. (2001) Somatic nuclear trasnfer in the rabbit. Theriogenology 55: 260 (abst).

    Google Scholar 

  • Chesné, P., Adenot, P. G., Viglietta, C., Baratte, M., Boulanger, L., and Renard, J. P. (2002) Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat. Biotechnol. 20(4): 366–369.

    Article  PubMed  Google Scholar 

  • Chrenek, P., Vasicek, D., Makarevich, A. V., Jurcik, R., Suvegova, K., Parkanyi, V., Bauer, M., Rafay, J., Batorova, A., Paleyanda, R. K. (2005) Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos. Transgenic Res. 14(4): 417–28

    Article  PubMed  CAS  Google Scholar 

  • Christians, E., Rao, V. H., and Renard, J. P. (1994) Sequential acquisition of transcriptional control during early embryonic development in the rabbit. Dev. Biol. 164: 160–172.

    Article  PubMed  CAS  Google Scholar 

  • Cibelli, J. B., Stice, S. L., Golueke, P. J., Kane, J. J., Jerry, J., Blackwell, C., de Leon, F. A. P., and Robl, J. M. (1998) Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280: 1256–1258.

    Article  PubMed  CAS  Google Scholar 

  • Collas, P. and Robl, J. M. (1990) Factors affecting the efficiency of nuclear transplantation in the rabbit embryo. Biol. Reprod. 43: 877–884.

    Article  PubMed  CAS  Google Scholar 

  • Collas, P. and Robl, J. M. (1991) Relationship between nuclear remodeling and development in nuclear transplant rabbit embryos. Biol. Reprod. 45: 455–465.

    Article  PubMed  CAS  Google Scholar 

  • Collas, P., Duby, R. T., and Robl, J. M. (1991) In vitro development of rabbit pronuclear embryos in rabbit peritoneal fluid. Biol. Reprod. 44: 1100–1107.

    Article  PubMed  CAS  Google Scholar 

  • Collas, P., Balise, J. J., and Robl, J. M. (1992a) Influence of cell cycle stage of the donor nucleus on development of nuclear transplant rabbit embryos. Biol. Reprod. 46(3): 492–500.

    Article  CAS  Google Scholar 

  • Collas, P., Pinto-Correia, C., Ponce de Leon, F. A., and Robl, J. M. (1992b) Effect of donor cell cycle stage on chromatin and spindle morphology in nuclear transplant rabbit embryos. Biol. Reprod. 46(3): 501–511.

    Article  CAS  Google Scholar 

  • Deng, M. and Yang, X. J. (2001) Full term development of rabbit oocytes fertilized by Intracytoplasmic sperm injection. Mol. Reprod. Dev. 59: 38–43.

    Article  PubMed  CAS  Google Scholar 

  • Denker, H. W. and Gerdes, H. J. (1979) The dynamic structure of rabbit blastocyst coverings. I. Transformation during regular preimplantation development. Anat. Embryol. (Berl) 157: 15–34.

    Article  CAS  Google Scholar 

  • Dinnyes, A., Dai, Y. P., Jiang, S., and Yang, X. Z. (2000) High developmental rates of vitrified bovine oocytes following parthenogenetic activation, in vitro fertilization, and somatic cell nuclear transfer. Biol. Reprod. 63: 513–518.

    Article  PubMed  CAS  Google Scholar 

  • Dinnyes, A., Dai, Y., Barber, M., Liu, L., Xu, J., Zhou, P., and Yang, X. (2001a) Development of cloned embryos from adult rabbit fibroblasts: effect of activation treatment and donor cell preparation. Biol. Reprod. 64: 257–263.

    Article  CAS  Google Scholar 

  • Dinnyes, A., King, T., Wilmut, I., and De Sousa, P. A. (2001b) Sheep somatic cell nuclear transfer: effect of breed and culture system on embryonic and fetal development. Theriogenology 55: 264.

    Google Scholar 

  • Dinnyes, A., Tian, X. C., and Yang, X. (2002) Cloning of rabbits in “Principles of cloning” (Jose Cibelli, Robert P. Lanza, Keith H.S. Campbell, Michael D. West, Eds.). Academic, San Diego, CA, pp. 343–366

    Chapter  Google Scholar 

  • Dinnyes, A., Tian, X. C., and Yang, X. (2008) Epigenetic Regulation of Foetal Development in Nuclear Transfer Animal Models. Reprod. Domes. Anim. 43: 302–309

    Article  Google Scholar 

  • Du, F., Giles, J. R., Foote, R. H., Graves, K. H., Yang, X., and Moreadith, R. W. (1995) Nuclear ransfer of putative rabbit embryonic stem cells leads to normal blastocyst development. J. Reprod. Fertil. 104: 219–223.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, J. A. (1968) The external development of the rabbit and rat embryo. In “Advances in Teratology” (Woollam, D. H. M., Ed.), Academic, New York, pp. 239–262.

    Google Scholar 

  • Ellington, J. E., Farrell, P. B., Simkin, M. E., Foote, R. H., Goldman, E. E., and McGrath, A. B. (1990) Development and survival after transfer of cow embryos cultured from 1–2-cells to morulae or blastocysts in rabbit oviducts or in a simple medium with bovine oviduct epithelial cells. J. Reprod. Fertil. 89: 293–299.

    Article  PubMed  CAS  Google Scholar 

  • Enright, B. P., Kubota, C., Yang, X., and Tian, X. C. (2003) Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2­-deoxycytidine. Biol Reprod. 69: 896–901.

    Article  PubMed  CAS  Google Scholar 

  • Escriba, M. J. and Garcia-Ximenez, F. (1999) Electroactivation of rabbit oocytes in an hypotonic ulsing medium and parthenogenetic in vitro development without cytochalasin B- diploidizing retreatment. Theriogenology 51: 963–973.

    Article  PubMed  CAS  Google Scholar 

  • Escriba, M. J. and Garcia-Ximenez, F. (2000) Influence of sequence duration and number of electrical pulses upon rabbit oocyte activation and parthenogenetic in vitro development. Anim. eprod. Sci. 59: 99–107.

    Article  CAS  Google Scholar 

  • Evans, M. J and Kaufman, M. (1981) Establishment in culture of pluripotencial stem cells from ouse embryos. Nature 292: 151–156

    Google Scholar 

  • Fang, Z. F., Gai, H., Huang, Y. Z., Li, S. G., Chen, X. J., Shi, J. J., Wu, L., Liu, A., Xu, P., and heng, H. Z. (2006) Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic r somatic cell nuclear transfer embryos. Exp. Cell Res. 312(18): 3669–3682.

    Article  PubMed  CAS  Google Scholar 

  • Farrell, P. B. and Foote, R. H. (1995) Beneficial effects of culturing rabbit zygotes to blastocysts in 5% oxygen and 10% carbon dioxide. J. Reprod. Fertil. 103: 127–130.

    Article  PubMed  CAS  Google Scholar 

  • Feussner, E. L., Lightkep, G. E., Hennesy, R. A., Hoberman, A. M., and Christian, M. S. (1992) A decade of rabbit fertility data: study of historical control animals. Teratology 46: 349–365.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, B. (1989) Effects of asynchrony on rabbit blastocyst development. J. Reprod. Fertil. 86: 479–491.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, B., Mootz, U., Denker, H. W., Lambertz, M., and Beier, H. M. (1991) The dynamic structure of rabbit blastocyst coverings. III. Transformation of coverings under non-physiological developmental conditions. Anat. Embryol. (Berl) 183: 17–27.

    CAS  Google Scholar 

  • Fissore, R. A. and Robl, J. M. (1993) Sperm, inositol trisphosphate, and thimerosal-induced intra-cellular Ca2 + elevations in rabbit eggs. Dev. Biol. 159: 122–130.

    Article  PubMed  Google Scholar 

  • Fissore, R. A. and Robl, J. M. (1994) Mechanism of calcium oscillations in fertilized rabbit eggs. Dev. Biol. 166: 634–642.

    Article  PubMed  CAS  Google Scholar 

  • Foote, R. H. and Carney, E. W. (2000) The rabbit as a model for reproductive and developmental toxicity studies. Reprod. Toxicol. 14: 477–493.

    Article  PubMed  CAS  Google Scholar 

  • Franke, W. W., Schmid, E., Osborn, M., and Weber, K. (1978) Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc. Natl. Acad. Sci. U. S. A 75: 5034–5038.

    Article  PubMed  CAS  Google Scholar 

  • Franke, W. W., Schmid, E., Winter, S., Osborn, M., and Weber, K. (1979) Widespread occurrence of intermediate-sized filaments of the vimentin- type in cultured cells from diverse vertebrates. Exp. Cell. Res. 123: 25–46.

    Article  PubMed  CAS  Google Scholar 

  • Galat, V. V., Lagutina, I. S., Mesina, M. N., Chernich, V. J., and Prokofiev, M. I. (1999) Developmental potential of rabbit nuclear transfer embryos derived from donor fetal fibroblast. Theriogenology 51: 203 (abst.)-203.

    Article  Google Scholar 

  • Giles, J. R. and Foote, R. H. (1997) Effects of gas atmosphere, platelet-derived growth factor and leukemia inhibitory factor on cell numbers of rabbit embryos cultured in a protein-free medium. Reprod. Nutr. Dev. 37: 97–104.

    Article  PubMed  CAS  Google Scholar 

  • Giles, J. R., Yang, X., Mark, W., and Foote, R. H. (1993) Pluripotency of cultured rabbit inner cell mass cells detected by isozyme analysis and eye pigmentation of fetuses following injection into blastocysts or morulae. Mol. Reprod. Dev. 36: 130–138.

    Article  PubMed  CAS  Google Scholar 

  • Graves, K. H. and Moreadith, R. W. (1993) Derivation and characterization of putative pluri-potential embryonic stem cells from preimplantation rabbit embryos. Mol. Reprod. Dev. 36(4): 424–433.

    Article  PubMed  CAS  Google Scholar 

  • Grocholova, R., Petr, J., Rozinek, J., and Jilek, F. (1997) The protein phosphatase inhibitor oka-daic acid inhibits exit from metaphase II in parthenogenetically activated pig oocytes. J. Exp. Zool. 277: 49–56.

    Article  PubMed  CAS  Google Scholar 

  • Hafez, E. S. E. (1964) Effects of over-crowding in utero on implantation and fetal development in the rabbit. J. Exp. Zool. 156: 269–288.

    Article  PubMed  CAS  Google Scholar 

  • Hagen, K. W. (1974). Colony Husbandry. In “The Biology of the Laboratory Rabbit” Weisbroth, S. H., Flatt, R. E., and Kraus, A. L., Eds.), Academic, New York, pp. 23–47.

    Google Scholar 

  • Hammer, R. E., Pursel, V. G., Rexroad, C. E., Wall, R. J., Bolt, D. J., Ebert, K. M., Palmiter, R. D., nd Brinster, R. L. (1985) Production of transgenic rabbits, sheep and pigs by microinjection. ature 315: 680–683.

    CAS  Google Scholar 

  • Harkness, J. E. and Wagner, J. E. (1995) The Biology and Medicine of Rabbits and Rodents. illiam and Wilkins, Baltimore, MD.

    Google Scholar 

  • Heape, W. (1890) Preliminary note on the transplantation and growth of mammalian ova within a terine foster-mother. Proc. R. Soc. Lond., B. Biol. Sci. 48: 457–459.

    Article  Google Scholar 

  • Henrion, G., Renard, J. P., Chesne, P., Oudin, J. F., Maniey, D., Brunet, A., Osborne, H. B., and uranthon, V. (2000) Differential regulation of the translation and the stability of two maternal ranscripts in preimplantation rabbit embryos. Mol. Reprod. Dev. 56: 12–25.

    Article  PubMed  CAS  Google Scholar 

  • Heyman, Y. and Renard, J. P. (1996) Cloning of domestic species. Anim. Reprod. Sci. 42: 27–436.

    Google Scholar 

  • Heyman, Y., Chesne, P., and Renard, J. P. (1990) Reprogrammation complete de noyaux embryon-naires congeles apres transfert nucleaire chez le lapin. C. R. Acad. Sci. Paris 311: 321–326.

    Google Scholar 

  • Hornsby, P. J, Yang, L., Gunter, L. E. (1992) Demethylation of satellite I DNA during senescence f bovine adrenocortical cells in culture. Mutat. Res. 275:13–19.

    PubMed  CAS  Google Scholar 

  • Iannaccone, P. M., Taborn, G. U., Garton, R. L, Caplice, M. D., and Brenin, D. R. (1994) luripotent embryonic stem cells from the rat ae capable of producing chimeras. Dev. Biol. 63: 288–292.

    Article  Google Scholar 

  • Inoue, K., Ogonuki, N., Yamamoto, Y., Noguchi, Y., Takeiri, S., Nakata, K, Miki, H., Kurome, M., agashima, H., and Ogura, A. (2002) Improved postimplantation development of rabbit uclear transfer embryos by activation with inositol 1,4,5-trisphosphate. Cloning Stem Cells (4): 311–317.

    Google Scholar 

  • Jiang, Y., Chen, T., Nan, C. L., Ouyang, Y. C., Sun, Q. Y., and Chen, D. Y. (2005) In vitro culture nd mtDNA fate of ibex-rabbit nuclear transfer embryos. Zygote 13(3): 233–240.

    Article  PubMed  CAS  Google Scholar 

  • Jin, D. I., Kim, D. K., Im, K. S., and Choi, W. S. (2000) Successful pregnancy after transfer of abbit blastocysts grown in vitro from single-cell zygotes. Theriogenology 54: 1109–1116.

    Article  PubMed  CAS  Google Scholar 

  • Joung, S. Y., Kim, H. J., Choi, W. S., Im, K. S., Lee, S. H., Park, C. S., and Jin, D. I. (2004) Effects f transferring in vitro-cultured rabbit embryos to recipient oviducts on mucin coat deposition, mplantation and development. Zygote 12(3): 215–219.

    Article  PubMed  Google Scholar 

  • Kane, M. T. and Foote, R. H. (1971) Factors affecting blastocyst expansion of rabbit zygotes and oung embryos in defined media. Biol. Reprod. 4: 41–47.

    PubMed  CAS  Google Scholar 

  • Kanka, J., Hozak, P., Heyman, Y., Chesne, P., Degrolard, J., Renard, J. P., and Flechon, J. E. (1996) ranscriptional activity and nucleolar ultrastructure of embryonic rabbit nuclei after transplantation to enucleated oocytes. Mol. Reprod. Dev. 43: 135–144.

    Article  PubMed  CAS  Google Scholar 

  • Kasai, M., Hamaguchi, Y., Zhu, S. E., Miyake, T., Sakurai, T., and Machida, T. (1992) High urvival of rabbit morulae after vitrification in an ethylene glycol-based solution by a simple ethod. Biol. Reprod. 46: 1042–1046.

    Article  PubMed  CAS  Google Scholar 

  • Kasinathan, P., Knott, J. G., Moreira, P. N., Burnside, A. S., Joseph, J. D., and Robl, J. M. (2001) ffect of fibroblast donor cell age and cell cycle on development of bovine nuclear transfer mbryos in vitro. Biol. Reprod. 64: 1487–1493.

    Article  PubMed  CAS  Google Scholar 

  • Kato, Y., Tani, T., Sotomaru, Y., Kurokawa, K., Kato, J., Doguchi, H., Yasue, H., and Tsunoda, Y. (1998) Eight calves cloned from somatic cells of a single adult. Science 282: 2095–2098.

    Article  PubMed  CAS  Google Scholar 

  • Kato, Y., Yabuuchi, A., Motosugi, N., Kato, J., and Tsunoda, Y. (1999) Developmental potential f mouse follicular epithelial cells and cumulus cells after nuclear transfer. Biol. Reprod. 61: 110–1114.

    Article  Google Scholar 

  • Kauffman, R. D., Schmidt, P. M., Rall, W. F., and Hoeg, J. M. (1998). Superovulation of rabbits ith FSH alters in vivo development of vitrified morulae. Theriogenology 50: 1081–1092.

    Article  PubMed  CAS  Google Scholar 

  • Kennelly, J. J. and Foote, R. H. (1965) Superovulatory response of pre- and post-puberal rabbits o commercially available gonadotrophins. J. Reprod. Fertil. 9: 131–145.

    Article  Google Scholar 

  • Kidder, J. D., Roberts, P. J., Simkin, M. E., Foote, R. H., and Richmond, M. E. (1999) Nonsurgical ollection and nonsurgical transfer of preimplantation embryos in the domestic rabbit (Oryctolagus cuniculus) and domestic ferret (Mustela putorius furo). J. Reprod. Fertil. 116: 35–242.

    Article  Google Scholar 

  • Kishigami, S., Mizutani, E., Ohta, H., Hikichi, T., Thuan, N. V., Wakayama, S., Bui, H. T., and akayama, T. (2006) Significant improvement of mouse cloning technique by treatment with richostatin A after somatic nuclear transfer. Biochem Biophys Res Commun. 340(1): 183–9.

    Article  PubMed  CAS  Google Scholar 

  • Koyama, H., Suzuki, H., Yang, X., Jiang, S., Foote, R. H. (1994) Analysis of polarity of bovine nd rabbit embryos by scanning electron microscopy. Biol. Reprod. 50: 163–70.

    Article  PubMed  CAS  Google Scholar 

  • Kubota, C., Yamakuchi, H., Todoroki, J., Mizoshita, K., Tabara, N., Barber, M., and Yang, X. Z. (2000) Six cloned calves produced from adult fibroblast cells after long-term culture. Proc. Natl. Acad. Sci. U. S. A 97: 990–995.

    Article  PubMed  CAS  Google Scholar 

  • Lagutina, I. S., Zakhartchenko, V. I., and Prokofiev, M. I. (1999) Nuclear transfer in rabbits and factors affecting it efficiency. Theriogenology 51: 207 (abst).

    Article  Google Scholar 

  • Lagutina, I. S., Mezina, M. N., Chernikh, V. J., Prokofiev, M. I., and Galat, V. V. (2000) Developmental potential of rabbit nuclear transfer embryos produced by various fusion/activation protocols. Theriogenology 53: 230 (abst).

    Google Scholar 

  • Lanza, R. P., Cibelli, J. B., Diaz, F., et al. (2000) Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer. Cloning 2: 79–91.

    Article  PubMed  CAS  Google Scholar 

  • Lebas, F. (1970) Description d'une machine a traire les lapines. Ann Zootech 19: 223–228.

    Article  Google Scholar 

  • Leiser, R. and Denker, H. W. (1988) The dynamic structure of rabbit blastocyst coverings. II. Ultrastructural evidence for a role of the trophoblast in neozona formation. Anat. Embryol. (Berl) 179: 129–134.

    Article  CAS  Google Scholar 

  • Li, G. P., Chen, D. Y., Lian, L., Han, Z. M., Zhu, Z. Y., and Seidel, G. E. Jr. (2002) Rabbit cloning: improved fusion rates using cytochalasin B in the fusion buffer. Mol. Reprod. Dev. 61(2): 187–191.

    Article  PubMed  CAS  Google Scholar 

  • Li, J. and Foote, R. H. (1996) Differential sensitivity of one-cell and two-cell rabbit embryos to sodium chloride and total osmolarity during culture into blastocysts. J. Reprod. Fertil. 108: 307–312.

    Article  PubMed  CAS  Google Scholar 

  • Li, J., Foote, R. H., and Simkin, M. (1993) Development of rabbit zygotes cultured in protein-free medium with catalase, taurine, or superoxide dismutase. Biol. Reprod. 49: 33–37.

    Article  PubMed  CAS  Google Scholar 

  • Li, S., Chen, X., Fang, Z., Shi, J., and Sheng, H. Z. (2006) Rabbits generated from fibroblasts through nuclear transfer. Reproduction 131(6): 1085–1090.

    Article  PubMed  CAS  Google Scholar 

  • Liu, J. L., Sung, L. Y., Du, F., Julian, M., Jiang, S., Barber, M., Xu, J., Tian, X. C., and Yang, X. (2004) Differential development of rabbit embryos derived from parthenogenesis and nuclear transfer. Mol. Reprod. Dev. 68(1): 58–64.

    Article  PubMed  CAS  Google Scholar 

  • Liu, L., Ju, J. C., and Yang, X. (1998) Differential inactivation of maturation-promoting factor and mitogen-activated protein kinase following parthenogenetic activation of bovine oocytes. Biol. Reprod. 59: 537–545.

    Article  PubMed  CAS  Google Scholar 

  • Lonergan, P., Dinnyes, A., Fair, T., Yang, X., and Boland, M. (2000) Bovine oocyte and embryo development following meiotic inhibition with butyrolactone I. Mol. Reprod. Dev. 57: 204–209.

    Article  PubMed  CAS  Google Scholar 

  • Meng, Q., Polgar, Z., Liu, J., and Dinnyes, A. (2008) Effect of Trichostatine A treatment on the term development of somatic cell nuclear transfer rabbit embryos Reprod. Fertil. Dev. 20(1): 103

    Article  Google Scholar 

  • Marcus, G. E., Shum, F. T., and Goldman, S. L. (1990) A device for collecting milk from rabbits. Lab. Anim. Sci. 40: 219 221.

    PubMed  CAS  Google Scholar 

  • Maurer, R. R., Hunt, W. L., Van Vleck, L. D., and Foote, R. H. (1968) Developmental potential of superovulated rabbit ova. J. Reprod. Fertil. 15: 171–175.

    Article  PubMed  CAS  Google Scholar 

  • Maurer, R. R. (1978) Advances in Rabbit Embryo Culture. In “Methods in Mammalian Reproduction” (Daniel, J. C., Ed.), Academic, New York, pp. 259–272.

    Google Scholar 

  • Mitalipov, S. M., White, K. L., Farrar, V. R., Morrey, J., and Reed, W. A. (1999) Development of nuclear transfer and parthenogenetic rabbit embryos activated with inositol 1,4,5-trisphos-phate. Biol. Reprod. 60: 821–827.

    Article  PubMed  CAS  Google Scholar 

  • Modlinski, J. A. and Smorag, Z. (1991) Preimplantation development of rabbit embryos after trasnfer of embryonic nuclei into different cytoplasmic environment. Mol. Reprod. Dev. 28: 361–372.

    Article  PubMed  CAS  Google Scholar 

  • Moens, A., Chastant, S., Chesne, P., Flechon, J. E., Betteridge, K. J., and Renard, J. P. (1996) Differential ability of male and female rabbit fetal germ cell nuclei to be reprogrammed by nuclear transfer. Differentiation 60: 339–345.

    Article  PubMed  CAS  Google Scholar 

  • Murakami, H. and Imai, H. (1996) Successful implantation of in vitro cultured rabbit embryos after uterine transfer: a role for mucin. Mol. Reprod. Dev. 43: 167–170.

    Article  PubMed  CAS  Google Scholar 

  • Nussbaum, D. J. and Prather, R. S. (1995) Differential effects of protein synthesis inhibitors on porcine oocyte activation. Mol. Reprod. Dev. 41: 70–75.

    Article  PubMed  CAS  Google Scholar 

  • Onishi, A., Iwamoto, M., Akita, T., Mikawa, S., Takeda, K., Awata, T., Hanada, H., and Perry, A. C. F. (2000) Pig cloning by microinjection of fetal fibroblast nuclei. Science 289: 1188–1190.

    Article  PubMed  CAS  Google Scholar 

  • Orsini, M. W. (1962) Study of ovo-implantation in the hamster, rat, mouse, guinea-pig, and rabbit in cleared uterine tracts. J. Reprod. Fertil. 3: 288–293.

    Article  PubMed  CAS  Google Scholar 

  • Ozil, J. P. (1990) The parthenogenetic development of rabbit oocytes after repetitive pulsatile electrical stimulation. Development 109: 117–127.

    PubMed  CAS  Google Scholar 

  • Ozil, J. P. and Huneau, D. (2001) Activation of rabbit oocytes: the impact of the Ca2 + signal regime on development. Development 128: 917–928.

    PubMed  CAS  Google Scholar 

  • Park, C. S., Jeon, B. G., Lee, K. M., Yin, X. J., Cho, S. K., Kong, I. K., Lee, H. J., and Choe, S. Y. (1998) Production of cloned rabbit embryos and offsprings by nuclear transplantation using in vitro matured oocytes. Theriogenology 49: 325 (abst).

    Article  Google Scholar 

  • Petters, R. M. and Wells, K. D. (1993) Culture of pig embryos. J. Reprod. Fertil. Suppl. 48: 61–73.

    PubMed  CAS  Google Scholar 

  • Pinto-Correia, C., Long, C. R., Chang, T., and Robl, J. M. (1995) Factors involved in nuclear reprogramming during early development in the rabbit. Mol. Reprod. Dev. 40: 292–304

    Article  PubMed  CAS  Google Scholar 

  • Piotrowska, K., Modlinski, J. A., Korwin-Kossakowski, M., and Karasiewicz, J. (2000) Effects of preactivation of ooplasts or synchronization of blastomere nuclei in G1 on preimplantation development of rabbit serial nuclear transfer embryos. Biol. Reprod. 63: 677–682.

    Article  PubMed  CAS  Google Scholar 

  • Polejaeva, I. A., Chen, S. H., Vaught, T. D., Page, R. L., Mullins, J., Ball, S., Dai, Y. F., Boone, J., Walker, S., Ayares, D. L., Colman, A., and Campbell, K. H. S. (2000) Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407: 86–90.

    Article  PubMed  CAS  Google Scholar 

  • Prather, R. S., Mayes, M. A., and Murphy, C. N. (1997) Parthenogenetic activation of pig eggs by exposure to protein kinase inhibitors. Reprod. Fertil. Dev. 9: 539–544.

    Article  PubMed  CAS  Google Scholar 

  • Rao, V. H., Heyman, Y., Chesne, P., and Renard, J. P. (1998) Freezing and recloning of nuclear transfer embryos in rabbit. Theriogenology 49: 328 (abst).

    Article  Google Scholar 

  • Renard, J. P., Bui, X. N., and Garnier, V. (1984) Two-step freezing of two-cell rabbit embryos after partial dehydration at room temperature. J. Reprod. Fertil. 71: 573–580.

    Article  PubMed  CAS  Google Scholar 

  • Rideout, W. M., Wakayama, T., Wutz, A., Eggan, K., Jackson-Grusby, L., Dausman, J., Yanagimachi, R., and Jaenisch, R. (2000) Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet. 24(2): 109–110.

    Article  PubMed  CAS  Google Scholar 

  • Rybouchkin, A., Kato, Y., and Tsunoda, Y. (2006) Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. Biol Reprod. 74: 1083–1089

    Article  PubMed  CAS  Google Scholar 

  • Santos, F. and Dean, W. (2004) Epigenetic reprogramming during early development in mammals. Reproduction 127: 643–651.

    Article  PubMed  CAS  Google Scholar 

  • Schnieke, A. E., Kind, A. J., Ritchie, W. A., Mycock, K., Scott, A. R., Ritchie, M., Wilmut, I., Colman, A., and Campbell, K. H. S. (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278: 2130–2133.

    Article  PubMed  CAS  Google Scholar 

  • Schoonjans, L., Albright, G. M., Li, J. L., Collen, D., and Moreadith, R. W. (1996) Pluripotential rabbit embryonic (ES) cells are capable of forming over coat color chimeras following injection into the blastocyst. Mol. Reprod. 45:439–443.

    Article  CAS  Google Scholar 

  • Schultz, R. M., Davis, W., Jr., Stein, P., and Svoboda, P. (1999) Reprogramming of gene expression during preimplantation development. J. Exp. Zool. 285: 276–282.

    Article  PubMed  CAS  Google Scholar 

  • Shi, L, Miao, Y., Ouyang, Y., Huang, J., Lei, Z., Yang, J., Han, Z., Son, X., Sun, Q., and Chen, D. (2008a) Trichostatin A (TSA) improves the development of rabbit-rabbit intraspe-cies cloned embryos, but not rabbit-human interspecies cloned embryos. Dev Dyn. 273: 640–648.

    Article  Google Scholar 

  • Shi, L, Ai, J., Ouyang, Y., Huang, J., Lei, Z., Wang, Q., Yin, S., Han, Z., Sun, Q., and Chen, D. (2008b) Trichostatin A and nuclear reprogramming of cloned rabbit embryos. J Anim Sci. 86: 1106–1113.

    Article  CAS  Google Scholar 

  • Shi, W., Dirim, F., Wolf, E., Zakhartchenko, V., and Haaf, T. (2004) Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos. Biol. Reprod. 71(1): 340–347.

    Article  PubMed  CAS  Google Scholar 

  • Shiga, K., Fujita, T., Hirose, K., Sasae, Y., and Nagai, T. (1999) Production of calves by transfer of nuclei from cultured somatic cells obtained from Japanese black bulls. Theriogenology 52: 527–535.

    Article  PubMed  CAS  Google Scholar 

  • Smith, L. C. and Wilmut, I. (1989) Influence of nuclear and cytoplasmic activity on the development in vivo of sheep embryos after nuclear transplantation. Biol. Reprod. 40: 1027–1035.

    Article  PubMed  CAS  Google Scholar 

  • Stice, S. L. and Keefer, C. L. (1993) Multiple generational bovine embryo cloning. Biol. Reprod. 48: 715–719.

    Article  PubMed  CAS  Google Scholar 

  • Stice, S. L. and Robl, J. M. (1988) Nuclear reprogramming in nuclear transplant rabbit embryos. Biol. Reprod. 39: 657–664.

    Article  PubMed  CAS  Google Scholar 

  • Stice, S. L. and Robl, J. M. (1990) Activation of mammalian oocytes by a factor obtained from rabbit sperm. Mol. Reprod. Dev. 25: 272–280.

    Article  PubMed  CAS  Google Scholar 

  • Stice, S. L., Keefer, C. L., Maki-Laurila, M., and Matthews, L. (1993) Donor blastomere cell cycle stage affects developmental competence of bovine nuclear transfer embryos. Theriogenology 39: 318 (abst).

    Article  Google Scholar 

  • Susko-Parrish, J. L., Leibfried-Rutledge, M. L., Northey, D. L., Schutzkus, V., and First, N. L. (1994) Inhibition of protein kinases after an induced calcium transient causes transition of bovine oocytes to embryonic cycles without meiotic completion. Dev. Biol. 166: 729–739.

    Article  PubMed  CAS  Google Scholar 

  • Swann, K. and Lai, F. A. (1997) A novel signalling mechanism for generating Ca2 + oscillations at fertilization in mammals. Bioessays 19: 371–378.

    Article  PubMed  CAS  Google Scholar 

  • Tan, J. H., Zhou, Q., Li, Z. Y., Sun, X. S., Liu, Z. H., and He, G. X. (1997) Embryo cloning by nuclear transplantation in rabbits. Theriogenology 47: 237 (abst).

    Article  Google Scholar 

  • Telford, N. A., Watson, A. J., and Schultz, G. A. (1990) Transition from maternal to embryonic control in early mammalian development: a comparison of several species. Mol. Reprod. Dev. 26: 90–100.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, E. M., Legouy, E., Christians, E., and Renard, J. P. (1995) Progressive maturation of chromatin structure regulates HSP70.1 gene expression in the preimplantation mouse embryo. Development 121: 3425–3437.

    PubMed  CAS  Google Scholar 

  • Thomson, J. A., Kalishman, J., Golos, T. G., Durning, M., Harris, C. P., Becker, R. A., and Hearn, J. P. (1995) Isolation of a primate embryonic stem cell line. Proc. Natl.Acad. Sci. USA 92: 7844–7848.

    Article  PubMed  CAS  Google Scholar 

  • Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshal, Swiergiel, V. S., and Jones, J. M. (1998) Embryonc stem cell lines derived from human blas-tocyst. Science 282: 1145–1147.

    Article  PubMed  CAS  Google Scholar 

  • Totey, S. M., Singh, G., Taneja, M., Pawshe, C. H., and Talwar, G. P. (1992) In vitro maturation, fertilization and development of follicular oocytes from buffalo (Bubalus bubalis). J. Reprod. Fertil. 95: 597–607.

    Article  PubMed  CAS  Google Scholar 

  • Tsunoda, Y., Soma, T., and Sugie, T. (1982) Effect of post-ovulatory age of recipient on survival of frozen-thawed rabbit morulae. J. Reprod. Fertil. 65: 483–487.

    Article  PubMed  CAS  Google Scholar 

  • Vajta, G. and Gjerris, M. (2006) Science and technology of farm animal cloning: State of the art. Animal Reprod. Sci. 92: 211–230.

    Article  Google Scholar 

  • Varian, N. B., Maurer, R. R., and Foote, R. H. (1967) Ovarian response and cleavage rate of ova in control and FSH-primed rabbits receiving varying levels of luteinizing hormone. J. Reprod. Fertil. 13: 67–73.

    Article  PubMed  CAS  Google Scholar 

  • Vignon, X., Chesne, P., Le Bourhis, D., Flechon, J. E., Heyman, Y., and Renard, J. P. (1998) Developmental potential of bovine embryos reconstructed from enucleated matured oocytes fused with cultured somatic cells. C. R. Acad. Sci. Paris 321: 735–745.

    PubMed  CAS  Google Scholar 

  • Vincent, C., Garnier, V., Heyman, Y., and Renard, J. P. (1989) Solvent effects on cytoskeletal organization and in-vivo survival after freezing of rabbit oocytes. J. Reprod. Fertil. 87: 809–820.

    Article  PubMed  CAS  Google Scholar 

  • Wakayama, T. and Yanagimachi, R. (2001) Mouse cloning with nucleus donor cells of different age and type. Mol. Reprod. Dev. 58: 376–383.

    Article  PubMed  CAS  Google Scholar 

  • Wakayama, T., Perry, A. C. F., Zuccotti, M., Johnson, K. R., and Yanagimachi, R. (1998) Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394: 369–374.

    Article  PubMed  CAS  Google Scholar 

  • Wang, F, Kou, Z., Zhang, Y., and Gao, S. (2007) Dynamic Reprogramming of Histone Acetylation and Methylation in the First Cell Cycle of Cloned Mouse Embryos. Biol Reprod. 77: 1007–1016.

    Article  PubMed  CAS  Google Scholar 

  • Wall, R. J., Powell, A. M., Paape, M. J., Kerr, D. E., Bannermann, D. D., Pursel, V. G., Wells, K. D., Talbot, N., and Hawk, H. W. (2005) Genetically enhanced cows resist intramam-mary Staphylococcus aureus infection. Nat. Biotechnol. 23: 445–451.

    Article  PubMed  CAS  Google Scholar 

  • Wang, S., Tang, X., Niu, Y., Chen, H., Li, B., Li, T., Zhang, X., Hu, Z., Zhou, Q., Ji, W. (2006) Generation and characterization of rabbit embryonic stem cells. Stem Cells 25(2): 481–489.

    Article  PubMed  CAS  Google Scholar 

  • Wang, W., Sun, Q., Hosoe, M., and Shioya, Y. (1997) Calcium- and meiotic-spindle-independent activation of pig oocytes by the inhibition of staurosporine-sensitive protein kinases. Zygote 5: 75–82.

    PubMed  Google Scholar 

  • Wells, D. N., Misica, P. M., McMillan, W. H., and Tervit, H. R. (1998) Production of cloned bovine fetuses following nuclear transfer using cells from a fetal fibroblast cell line. Theriogenology 49: 330.

    Article  Google Scholar 

  • Willadsen, S. M. (1986) Nuclear transplantation in sheep embryos. Nature 320: 63–65.

    Article  PubMed  CAS  Google Scholar 

  • Willadsen, S. M. (1989) Cloning of sheep and cow embryos. Genome 31: 956–962.

    PubMed  CAS  Google Scholar 

  • Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., and Campbell, K. H. S. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385: 810–813.

    Article  PubMed  CAS  Google Scholar 

  • Xu, J., Sung, L.-Y., Zhang, J., Tian, X., Chen, Y. E., Yang, X., and Du, F. (2007) Trichostatin A Improved the Quality of Rabbit Nuclear Transfer Embryos. Reprod Fertil Dev. 19: 165.

    Article  Google Scholar 

  • Yang, F., Hao. R., Kessler, B., Brem, G., Wolf, E., and Zakhartchenko, V. (2007) Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation. Reproduction 133(1): 219–230.

    Article  PubMed  CAS  Google Scholar 

  • Yang, X., Chen, Y., Chen, J., and Foote, R. H. (1990a) Potential of hypertonic medium treatment for embryo micromanipulation: I. Survival of rabbit embryos in vitro and in vivo following sucrose treatment. Mol. Reprod. Dev. 27: 110–117.

    CAS  Google Scholar 

  • Yang, X., Zhang, L., Kovacs, A., Tobback, C., and Foote, R. H. (1990b) Potential of hypertonic medium treatment for embryo micromanipulation: II. Assessment of nuclear transplantation methodology, isolation, subzona insertion, and electrofusion of blastomeres to intact or functionally enucleated oocytes in rabbits. Mol. Reprod. Dev. 27: 118–129.

    CAS  Google Scholar 

  • Yang, X. (1991) Featured article: Embryo cloning by nuclear transfer in cattle and rabbits. Embryo Transfer Newslett. 9: 10–22.

    Google Scholar 

  • Yang, X., Jiang, S., Kovacs, A., and Foote, R. H. (1992) Nuclear totipotency of cultured rabbit moru-lae to support full-term development following nuclear transfer. Biol. Reprod. 47: 636–643.

    Article  PubMed  CAS  Google Scholar 

  • Yang, X. Z. and Foote, R. H. (1987) Production of identical twin rabbits by micromanipulation of embryos. Biol. Reprod. 37: 1007–1014.

    Article  PubMed  CAS  Google Scholar 

  • Yang, X. Z. and Foote, R. H. (1990) Survival of bisected rabbit morulae transferred to synchronous and asynchronous recipients. Mol. Reprod. Dev. 26: 6–11.

    Article  PubMed  CAS  Google Scholar 

  • Yin, X. J., Tani, T., Kato, Y., and Tsunoda, Y. (2000) Development of rabbit parthenogenetic oocytes and nuclear-transferred oocytes receiving cultured cumulus cells. Theriogenology 54: 1469–1476.

    Article  PubMed  CAS  Google Scholar 

  • Yin, X. J., Kato, Y., and Tsunoda, Y. (2002a) Effect of enucleation procedures and maturation conditions on the development of nuclear-transferred rabbit oocytes receiving male fibroblast cells. Reproduction 124(1): 41–47.

    Article  CAS  Google Scholar 

  • Yin, X. J., Kato, Y., and Tsunoda, Y. (2002b) Effect of delayed enucleation on the developmental potential of nuclear-transferred oocytes receiving adult and fetal fibroblast cells. Zygote 10(3): 217–222.

    Article  Google Scholar 

  • Zakhartchenko, V., Alberio, R., Stojkovic, M., Prelle, K., Schernthaner, W., Stojkovic, P., Wenigerkind, H., Wanke, R., Duchler, M., Steinborn, R., Mueller, M., Brem, G., and Wolf, E. (1999) Adult cloning in cattle: Potential of nuclei from a permanent cell line and from primary cultures. Mol. Reprod. Dev. 54: 264–272.

    Article  PubMed  CAS  Google Scholar 

  • Zhou, Q., Li, Z. Y., Liu, Z. H., Sun, X. S., He, G. X., and Tan, J. H. (1997) Nuclear transplantation by microinjection in rabbits. Theriogenology 47: 239 (abst).

    Article  Google Scholar 

  • Ziomek, C. A., Chatot, C. L., and Manes, C. (1990) Polarization of blastomeres in the cleaving rabbit embryo. J. Exp. Zool. 256: 84–91.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Genetic Reprogramming Group, Agricultural Biotechnology Center, Godollo, Hungary

    Andras Dinnyes, Zsuzsanna Polgar & Qinggang Meng

  2. Molecular Animal Biotechnology Laboratory, Szent Istvan University, Pater K. u. 1., Godollo, H-2103, Hungary

    Andras Dinnyes

  3. Faculty of Natural Sciences, Constantine the Philosopher University, Slovakia

    Zsuzsanna Polgar

  4. Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, USA

    Qinggang Meng

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  1. Andras Dinnyes
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  1. Institute of Research in Agronomy, Jouy en Josas, France

    Louis-Marie Houdebine (Doctor) (Doctor)

  2. Department of Molecular Pathology, Interdisciplinary Graduate, School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

    Jianglin Fan (Chairman and Professor) (Chairman and Professor)

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Dinnyes, A., Polgar, Z., Meng, Q. (2009). Rabbit Cloning. In: Houdebine, LM., Fan, J. (eds) Rabbit Biotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2227-1_10

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