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Mechanismen van diepe hersenstimulatie

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Samenvatting

De mechanismen die ten grondslag liggen aan de effectiviteit van DBS zijn uitvoerig onderzocht en er is een aantal belangrijke mechanismen aangetoond. Het meeste onderzoek is verricht op het gebied van de ziekte van Parkinson, in proefdiermodellen en bij patiënten. Samenvattend kan gesteld worden dat de mechanismen betrekking hebben op lokale en netwerkeffecten. De lokale effecten op de cellen in de directe nabijheid van de stimulatie-elektrode zijn inhibitoir, terwijl de effecten op cellen op afstand en op axonen in de directe omgeving stimulerend kunnen zijn. Recentere inzichten verklaren het effect van DBS door te interfereren met pathologische gesynchroniseerde oscillaties die in de cortico-basale kernen-thalamocorticale netwerken aanwezig zijn.

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Author information

Authors and Affiliations

  1. Afdeling Neurochirurgie, Maastricht UMC+, Maastricht, The Netherlands

    Ali Jahanshahi, Koo van Overbeeke & Yasin Temel

Authors
  1. Ali Jahanshahi
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  2. Koo van Overbeeke
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  3. Yasin Temel
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Jahanshahi, A., van Overbeeke, K., Temel, Y. (2016). Mechanismen van diepe hersenstimulatie. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_3

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_3

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