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9 Immunologische bescherming van de mondholte

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Samenvatting

  • Het merendeel van de serumimmuunglobulinen behoort tot de IgG-klasse. De immuunglobulinen in speeksel behoren voornamelijk tot de IgA-klasse.

  • Speeksel-IgA is aanwezig als een complex, waarin twee IgA-moleculen, een J-keten (joining chain) en een secretory component aanwezig zijn. Dit complex wordt aangeduid als secretie-IgA (S-IgA).

  • Van de S-IgA-moleculen van mondvloeistof wordt 98% geproduceerd binnen de speekselklieren, slechts 2% is als monomeer afkomstig uit serum.

  • In speeksel behoort ongeveer 60% van de S-IgA-moleculen tot de IgA1-subklasse en in serum 80%. IgA1-moleculen worden onder invloed van proteolytische enzymen gemakkelijker afgebroken dan IgA2-moleculen.

  • De hoogste S-IgA-concentratie wordt aangetroffen in muceus labiaal speeksel. De labiale speekselkliertjes leveren ongeveer 35% van het S-IgA in totaalspeeksel.

  • Patiënten die onvoldoende S-IgA hebben, vertonen een hogere cariësscore, terwijl daarnaast S. mutans in hogere frequentie aanwezig is.

  • De belangrijkste functie van S-IgA is het beschermen van de mucosale membranen tegen kolonisatie van micro-organismen. Dit geschiedt mogelijk in samenwerking met andere speekselcomponenten, zoals lactoferrine, agglutinine en mucinen.

  • Waarschijnlijk behoort vaccinatie tegen cariës voorlopig niet tot de mogelijkheden, onder andere door de grote verscheidenheid aan micro-organismen en door aangetoonde bijwerkingen in dierexperimentele studies, zoals inductie van bepaalde auto-immuunreacties en ontstekingen.

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Copyright information

© Bohn Stafleu van Loghum, onderdeel van Springer Uitgeverij 2008

Authors and Affiliations

  1. 1.Sectie Orale BiochemieAcademisch Centrum Tandheelkunde Amsterdam (ACTA), Vrije Universiteit en Universiteit van AmsterdamAmsterdam

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