Advertisement

18 Leeftijd en speeksel

Chapter
  • 806 Downloads

Samenvatting

Uit de onderzoeksgegevens van speeksel van de oudere mens kan geconcludeerd worden dat:

  • onder normale omstandigheden geen verlaagde speekselklierfunctie optreedt;

  • speekselklieren een overcapaciteit hebben aan secretoire cellen en aan secretiegranules;

  • hyposalivatie vaak te verbeteren is door stimulatie van het kauwproces en door smaakstimulatie;

  • indien de speekselsecretie niet te verbeteren is, de voornaamste oorzaak een speekselklierdisfunctie is als gevolg van:

    • het gebruik van medicatie met een anticholinerge hoofdwerking;

    • een systemische ziekte, vooral het syndroom van Sjögren en andere auto-immuunziekten;

    • een speekselklieraandoening, onder andere na radiotherapie.

In ieder geval dient de droge-mondklacht serieus te worden genomen en niet te worden afgedaan met ‘het hoort nu eenmaal bij het ouder worden’ en ‘u moet ermee leren leven’, of ‘een droge mond is niet levensbedreigend’. Als de arts en tandarts de klacht serieus nemen, kan naar een doelmatige therapie worden gezocht, waarmee dit voor de patiënt vaak lastige euvel kan worden verholpen of verlicht.

Literatuur

  1. Aguirre A., M.J. Levine, R.E. Cohen en L.A. Tabak. Immunochemical quantitation of α-amylase and secretory IgA in parotid saliva from people of various ages. Archs Oral Biol. 32, (1987)297–301.CrossRefGoogle Scholar
  2. Baum B.J. Saliva secretion and composition. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, pp. (1987)126–134.Google Scholar
  3. Bourdiol P., L. Mioche en S. Monier. Effect of age on salivary flow obtained under feeding and non-feeding conditions. J. Oral Rehabil. 31, (2004)445–452.PubMedCrossRefGoogle Scholar
  4. Bretz W.A., W.J. Loesche, Y.M. Chen, M.A. Schork, B.L. Dominguez en N. Grossman. Minor salivary gland secretion in the elderly. Oral Surg. Oral Med. Oral Pathol. Oral Med. 89, (2000)696–701.CrossRefGoogle Scholar
  5. Caplan D.J. en R.J. Hunt. Salivary flow and risk of tooth loss in an elderly population. Commun. Dent. Oral Epidemiol. 24, (1996)68–71.CrossRefGoogle Scholar
  6. Dayan D., M. Vered, T. Paz en A. Buchner. Aging of human palatal salivary glands: a histomorphometric study. Exptl. Gerontol. 35, (2000)85–93.CrossRefGoogle Scholar
  7. Denny P.C., P.A. Denny, D.K. Klauser, S.H. Hong,M. Navazesh en L.A. Tabak. Age-related changes in mucins from human whole saliva. J. Dent. Res. 70, (1991)1320–1327.PubMedCrossRefGoogle Scholar
  8. Dodds M.W.J., D.A. Johnson en C.-K. Yeh. Health benefits of saliva: a review. J. Dent. 33, (2005)223–233.PubMedCrossRefGoogle Scholar
  9. Drummond J.R. Morphological changes in human salivary glands. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, (1987)pp. 31–39.Google Scholar
  10. Enns M.P. en D.E. Hornung. Comparisons of the estimates of smell, taste and overall intensity in young and elderly people. Chem. Senses 13, (1988)131–139.CrossRefGoogle Scholar
  11. Ferguson D.B. The flow rate of unstimulated human labial gland saliva. J. Dent. Res. 75, (1996)980–985.PubMedCrossRefGoogle Scholar
  12. Friedlander A.H. en I.K. Friedlander. Late-life depression: its oral health significance. Int. Dent. J. 53, (2003-41–50.PubMedCrossRefGoogle Scholar
  13. Fukunaga A., H. Uematsu en K. Sugimoto. Influences of aging on taste perception and oral somatic sensation. J. Gerontol. Med. Sci. 60A, (2005)109–113.CrossRefGoogle Scholar
  14. Gandara B.K., K.T. Izutsu, E.L. Truelove, W.Y. Ensign en E.E. Sommers. Age-related salivary flow rate changes in controls and patients with oral lichen planus. J. Dent. Res. 64, (1985)1149–1151.CrossRefGoogle Scholar
  15. E.M. Ghezi en J.A. Ship. Aging and secretory reserve capacity of major salivary glands. J. Dent. Res. 82, (2003)844–848.CrossRefGoogle Scholar
  16. Hershkovich O., I. Shafat en R.M. Nagler. Age-related changes in salivary antioxidant profile: Possible implications for oral cancer. J. Gerontol. Biol Sci. Med. Sci. 62, (2007)361–366.CrossRefGoogle Scholar
  17. Hiratsuka Y., T. Kamino, Y. Nagata, S. Takahashi, K. Asai, Ishikaw, e.a. Microarray analysis of gene expression changes in aging in mouse submandibular gland. J. Dent. Res. 81, (2002)679–682.PubMedCrossRefGoogle Scholar
  18. Hirotomi T., A. Yoshihara, H. Ogawa, K. Ito, A. Igarashi en H. Miyazaki. A preliminary study on the relationship between stimulated saliva and periodontal conditions in community-dwelling elderly people. J. Dent. 34, (2006)692–698.PubMedCrossRefGoogle Scholar
  19. Ikebe K., K. Moril, K. Matsuda, K. Hata en T. Nokubi. Association of candidal activity with denture use and salivary flow in symptom-free adults over 60 years. J. Oral Rehabil. 33, (2006)36–42.PubMedCrossRefGoogle Scholar
  20. Ikebe K, K. Matsuda, K. Morii, T. Hazeyama, R. Kagawa, T. Ogawa, e.a. Relationship between bite force and salivary flow in older adults. Oral Surg. Oral Med. Pathol. Oral Radiol. Endod. 104, (2007)510–515.CrossRefGoogle Scholar
  21. Johnson D.A., C.-K. Yeh en M.W.J. Dodds. Effect of donor age on the concentrations of histatins in human parotid and submandibular/sublingual saliva. Archs Oral Biol. 45, (2000)731–740.CrossRefGoogle Scholar
  22. Jones J.M., C.A. Watkins, J.S. Hand, J.J. Warren en H.J. Cowen. Comparison of three salivary flow rate assessment methods in an elderly population. Commun. Dent. Oral Epidemiol. 28, (2000)177–184.CrossRefGoogle Scholar
  23. Kikuchi M., T. Inagaki, K. Ogawa, S. Banno, Y. Matsumoto, R. Ueda, e.a. Histopathological inveastigation of salivary glands in the asymptomatic elderly. Archs Geront. Geratr. 38, (2004)131–138.CrossRefGoogle Scholar
  24. Kim S.K. Protein synthesis in salivary glands as related to aging. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, (1987)pp.96–110.Google Scholar
  25. Kim S.K. en E.D. Allen. Structural and functional changes in salivary glands during aging. Microsc. Res. Techn. 28, (1994)243–253.CrossRefGoogle Scholar
  26. Koller M.M., R.A. Cowman, M.G. Humphreys-Beher en P.J. Scarpace. An analysis of submandibular gland function with desipramine and age in female NIA Fischer 344 rats. Mech. Ageing Dev. 119, (2000)131–147.PubMedCrossRefGoogle Scholar
  27. Liu P., P.A. Denny en P.C. Denny. The effect of ageing on parenchymal cell populations in adult female mouse submandibular gland. Archs Oral Biol. 45, (2000)585–592CrossRefGoogle Scholar
  28. Michels L.F.E. en A. van Nieuw Amerongen. Problematiek van ouder worden en mondgezondheid. In: Geriatrische Tandheelkunde. Eds. C. de Baat en W. Kalk. 1999, Hoofdstuk 11. pp. 117–130.Google Scholar
  29. Mojet J., E. Christ-Hazelhof en J. Heidema. Taste perception with age: Generic or specific losses in threshold sensitivity to the five basic tastes? Chem. Senses 26, (2001)845–860.CrossRefGoogle Scholar
  30. Moreira C.F., L.R. Azevedo, J.R. Pereira Lauris, R. Taga en J.H. Damante. Quatitative age-related differences in human sublingual gland. Archs Oral Biol. 51, (2006)960–966.CrossRefGoogle Scholar
  31. Moritsuka M., Y. Kitasako, M.F. Burrow, M. Ikeda, J. Tagami en S. Nomura. Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages. J. Dent. 34, (2006)716–720.PubMedCrossRefGoogle Scholar
  32. Nagler R.M. en O. Hershkovich. Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints. Aging Clin. Exptl Res. 17, (2005)358–366.CrossRefGoogle Scholar
  33. Närhi T.O., J.H. Meurman, A. Ainamo, J.M. Nevalainen, K.G. Schmidt-Kaunisaho, P. Siukosaari, e.a. Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86- year-old inhabitants in Helsinki, Finland. J. Dent. Res. 71, (1992)1875–1880.PubMedCrossRefGoogle Scholar
  34. Närhi T.O. Prevalence of subjective feelings of dry mouth in the elderly. J. Dent. Res. 73, (1994)20–25.PubMedCrossRefGoogle Scholar
  35. Närhi T.O., J. Tenovuo, A. Ainamo en P. Vilja. Antimicrobial factors, sialic acid, and protein concentration in whole saliva of the elderly. Scand. J. Dent. Res. 102, (1994)120–125.PubMedGoogle Scholar
  36. Närhi T.O., J.H. Meurman en A. Ainamo. Xerostomia and hyposalivation. Causes, consequences and treatment in the elderly. Drugs Aging 15, (1999)103–116.PubMedCrossRefGoogle Scholar
  37. Nederfors T., R. Isaksson, H. Mörnstad en C. Dahlof. Prevalence of perceived symptoms of dry mouth in an adult Swedish population – Relation to age, sex and pharmacotherapy. Commun. Dent. Oral Epidemiol. 25, (1997)211–216.CrossRefGoogle Scholar
  38. Pajukoski H., J.H. Meurman, P. Halonen en R. Sulkava. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases. Oral Surg.Oral Med. Oral Pathol. Oral Radiol. Endod. 92, (2001)641–649.PubMedCrossRefGoogle Scholar
  39. Percival R.S., S.J. Challacombe en P.D. Marsh. Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J. Dent. Res. 73, (1994)1416–1420.PubMedGoogle Scholar
  40. Putten G.J. van der, H.S. Brand, C.P. Bots en A. van Nieuw Amerongen. Prevalentie van xerostomie en hyposalivatie in een verpleeghuis en de relatie met voorgeschreven medicatie. Tijdschr. Gerontol. Geriatr. 34, (2003)30–36.PubMedGoogle Scholar
  41. Scott J., E.A. Flower en J. Burns. A quantitative study of histological changes in the human parotid gland occurring with adult age. J. Oral Pathol. 16, (1987)505–510.PubMedCrossRefGoogle Scholar
  42. Shern R.J., P.C. Fox en S.H. Li. Influence of age on the secretory rates of the human minor salivary glands and whole saliva. Archs Oral Biol. 38, (1993)755–761.CrossRefGoogle Scholar
  43. Ship J.A. en B.J. Baum. Is reduced salivary flow normal in old people? The Lancet 336, (1991)1507.CrossRefGoogle Scholar
  44. Ship J.A. en J.M. Weiffenbach. Age, gender, medical treatment, and medication effects on smell identification. J. Gerontol. 48, (1993)M26–M32.PubMedCrossRefGoogle Scholar
  45. Ship J.A., N.E. Nolan en S.A. Puckett. Longitudinal analysis of parotid and submandibular flow rates in healthy, different-aged adults. J. Gerontol. Med. Sci. 50A, (1995)M285–M289.CrossRefGoogle Scholar
  46. Shugars D.C., C.A. Watkins en H.J. Cowen. Salivary concentration of secretory leukocyte protease inhibitor, an antimicrobial protein, is decreased with advanced age. Gerontology 47, (2001)246–253.PubMedCrossRefGoogle Scholar
  47. Smith D.J., K. Joshipura, R. Kent en M.A. Taubman. Effect of age on immunoglobulin content and volume of human labial gland saliva. J. Dent. Res. 71, (1992)1891–1894.PubMedCrossRefGoogle Scholar
  48. Spitzer M.E. Taste acuity in institutionalized and non-institutionalized elderly men. J. Gerontol. 43, (1988)71–74.CrossRefGoogle Scholar
  49. Sreebny L.M., A. Valdini en A. Yu. Xerostomia. Part II. Relationship to nonoral symptoms, drugs and diseases. Oral Surg. Oral Med. Oral Pathol. 68, (1989)419–427.PubMedCrossRefGoogle Scholar
  50. Stewart-Knox B.J., E.E.A. Simpson, H. Parr, G. Rae, A. Polito, F. Intorre, e.a. Zinc status and taste acuity in older Europeans: the ZENITH study. Eur. J. Clin. Nutr. 59, (2005)S31–S–36.PubMedCrossRefGoogle Scholar
  51. Tanida T., E. Ueta, A. Tobiume, T. Hamada, F. Rao en T. Osaki. Influence of aging on candidal growth and adhesion regulatory agents in saliva. J. Oral Pathol. Med. 30, (2001)328–335.PubMedCrossRefGoogle Scholar
  52. Thomsen W.M., A.J. Spencer, G.D. Slade en J.M. Chalmers. Is medication a risk factor for dental caries among older people. Commun. Dent. Oral Epidemiol. 30, (2002)224–232.CrossRefGoogle Scholar
  53. Turner M.D. en J.A. Ship. Dry mouth and its effects on the oral health of elderly people. J. Am. Dental Assoc. 138, (2007)15S–20S.CrossRefGoogle Scholar
  54. Tylenda C.A., J.A. Ship, P.C. Fox en B.J. Baum. Evaluation of submandibular salivary flow rate in different age groups. J. Dent. Res. 67, (1988)1225–1228.PubMedCrossRefGoogle Scholar
  55. Vered M., A. Buchner, P. Boldon en D. Dayan. Agerelated histomorphometric changes in labial salivary glands with special reference to the acinar component. Exptl. Gerontol. 35, (2000)1075–1084.CrossRefGoogle Scholar
  56. Vissink A., F.K.L. Spijkervet en A. van Nieuw Amerongen. Ageing and saliva. Spec. Care Dent. 16, (1996)95–103.CrossRefGoogle Scholar
  57. Vissink A., F.K.L. Spijkervet en A. van Nieuw Amerongen. Veranderingen in secretie en samenstelling van speeksel met het ouder worden. Ned. Tijdschr. Tandheelkd. 104, (1997)186–189.PubMedGoogle Scholar
  58. Wu A.J., J.C. Atkinson, P.C. Fox, B.J. Baum en J.A. Ship. Cross-sectional and longitudinal analysis of stimulated parotid salivary constituents in healthy, different-aged subjects. J. Gerontol.: Med.Sci. 48, (1993)M219–M224.CrossRefGoogle Scholar
  59. Wu A.J., B.J. Baum en J.A. Ship. Extended stimulated parotid and submandibular secretion in a healthy young and old population. J. Geront. Med. Sci. 50A, (1995)M45–M48.CrossRefGoogle Scholar
  60. Yeh C.K., D.A. Johnson en M.W.J. Dodds. Impact of aging on human salivary gland function: A community-based study. Aging Clin. Exptl. Res. 10, (1998)421–428.CrossRefGoogle Scholar
  61. Yoshihara A., T. Hirotomi, N. Takano, T. Kondo en N. Hanada. Serum markers of chronic dehydration are associated with saliva spinability. J. Oral Rehabil. 34, (2007)733–738.PubMedCrossRefGoogle Scholar
  62. Zussman E., A.L. Yarin en R.M. Nagler. Age- and flow-dependency of salivary viscoelasticity. J. Dent. Res. 86, (2007)281–285.PubMedCrossRefGoogle Scholar

Copyright information

© Bohn Stafleu van Loghum, onderdeel van Springer Uitgeverij 2008

Authors and Affiliations

  1. 1.Sectie Orale BiochemieAcademisch Centrum Tandheelkunde Amsterdam (ACTA), Vrije Universiteit en Universiteit van AmsterdamAmsterdam

Personalised recommendations