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Samenvatting

Uit de onderzoeksgegevens van speeksel van de oudere mens kan geconcludeerd worden dat:

  • onder normale omstandigheden geen verlaagde speekselklierfunctie optreedt;

  • speekselklieren een overcapaciteit hebben aan secretoire cellen en aan secretiegranules;

  • hyposalivatie vaak te verbeteren is door stimulatie van het kauwproces en door smaakstimulatie;

  • indien de speekselsecretie niet te verbeteren is, de voornaamste oorzaak een speekselklierdisfunctie is als gevolg van:

    • het gebruik van medicatie met een anticholinerge hoofdwerking;

    • een systemische ziekte, vooral het syndroom van Sjögren en andere auto-immuunziekten;

    • een speekselklieraandoening, onder andere na radiotherapie.

In ieder geval dient de droge-mondklacht serieus te worden genomen en niet te worden afgedaan met ‘het hoort nu eenmaal bij het ouder worden’ en ‘u moet ermee leren leven’, of ‘een droge mond is niet levensbedreigend’. Als de arts en tandarts de klacht serieus nemen, kan naar een doelmatige therapie worden gezocht, waarmee dit voor de patiënt vaak lastige euvel kan worden verholpen of verlicht.

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Literatuur

  • Aguirre A., M.J. Levine, R.E. Cohen en L.A. Tabak. Immunochemical quantitation of α-amylase and secretory IgA in parotid saliva from people of various ages. Archs Oral Biol. 32, (1987)297–301.

    Article  CAS  Google Scholar 

  • Baum B.J. Saliva secretion and composition. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, pp. (1987)126–134.

    Google Scholar 

  • Bourdiol P., L. Mioche en S. Monier. Effect of age on salivary flow obtained under feeding and non-feeding conditions. J. Oral Rehabil. 31, (2004)445–452.

    Article  CAS  PubMed  Google Scholar 

  • Bretz W.A., W.J. Loesche, Y.M. Chen, M.A. Schork, B.L. Dominguez en N. Grossman. Minor salivary gland secretion in the elderly. Oral Surg. Oral Med. Oral Pathol. Oral Med. 89, (2000)696–701.

    Article  CAS  Google Scholar 

  • Caplan D.J. en R.J. Hunt. Salivary flow and risk of tooth loss in an elderly population. Commun. Dent. Oral Epidemiol. 24, (1996)68–71.

    Article  CAS  Google Scholar 

  • Dayan D., M. Vered, T. Paz en A. Buchner. Aging of human palatal salivary glands: a histomorphometric study. Exptl. Gerontol. 35, (2000)85–93.

    Article  CAS  Google Scholar 

  • Denny P.C., P.A. Denny, D.K. Klauser, S.H. Hong,M. Navazesh en L.A. Tabak. Age-related changes in mucins from human whole saliva. J. Dent. Res. 70, (1991)1320–1327.

    Article  CAS  PubMed  Google Scholar 

  • Dodds M.W.J., D.A. Johnson en C.-K. Yeh. Health benefits of saliva: a review. J. Dent. 33, (2005)223–233.

    Article  PubMed  Google Scholar 

  • Drummond J.R. Morphological changes in human salivary glands. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, (1987)pp. 31–39.

    Google Scholar 

  • Enns M.P. en D.E. Hornung. Comparisons of the estimates of smell, taste and overall intensity in young and elderly people. Chem. Senses 13, (1988)131–139.

    Article  Google Scholar 

  • Ferguson D.B. The flow rate of unstimulated human labial gland saliva. J. Dent. Res. 75, (1996)980–985.

    Article  CAS  PubMed  Google Scholar 

  • Friedlander A.H. en I.K. Friedlander. Late-life depression: its oral health significance. Int. Dent. J. 53, (2003-41–50.

    Article  PubMed  Google Scholar 

  • Fukunaga A., H. Uematsu en K. Sugimoto. Influences of aging on taste perception and oral somatic sensation. J. Gerontol. Med. Sci. 60A, (2005)109–113.

    Article  Google Scholar 

  • Gandara B.K., K.T. Izutsu, E.L. Truelove, W.Y. Ensign en E.E. Sommers. Age-related salivary flow rate changes in controls and patients with oral lichen planus. J. Dent. Res. 64, (1985)1149–1151.

    Article  Google Scholar 

  • E.M. Ghezi en J.A. Ship. Aging and secretory reserve capacity of major salivary glands. J. Dent. Res. 82, (2003)844–848.

    Article  Google Scholar 

  • Hershkovich O., I. Shafat en R.M. Nagler. Age-related changes in salivary antioxidant profile: Possible implications for oral cancer. J. Gerontol. Biol Sci. Med. Sci. 62, (2007)361–366.

    Article  Google Scholar 

  • Hiratsuka Y., T. Kamino, Y. Nagata, S. Takahashi, K. Asai, Ishikaw, e.a. Microarray analysis of gene expression changes in aging in mouse submandibular gland. J. Dent. Res. 81, (2002)679–682.

    Article  CAS  PubMed  Google Scholar 

  • Hirotomi T., A. Yoshihara, H. Ogawa, K. Ito, A. Igarashi en H. Miyazaki. A preliminary study on the relationship between stimulated saliva and periodontal conditions in community-dwelling elderly people. J. Dent. 34, (2006)692–698.

    Article  CAS  PubMed  Google Scholar 

  • Ikebe K., K. Moril, K. Matsuda, K. Hata en T. Nokubi. Association of candidal activity with denture use and salivary flow in symptom-free adults over 60 years. J. Oral Rehabil. 33, (2006)36–42.

    Article  CAS  PubMed  Google Scholar 

  • Ikebe K, K. Matsuda, K. Morii, T. Hazeyama, R. Kagawa, T. Ogawa, e.a. Relationship between bite force and salivary flow in older adults. Oral Surg. Oral Med. Pathol. Oral Radiol. Endod. 104, (2007)510–515.

    Article  Google Scholar 

  • Johnson D.A., C.-K. Yeh en M.W.J. Dodds. Effect of donor age on the concentrations of histatins in human parotid and submandibular/sublingual saliva. Archs Oral Biol. 45, (2000)731–740.

    Article  CAS  Google Scholar 

  • Jones J.M., C.A. Watkins, J.S. Hand, J.J. Warren en H.J. Cowen. Comparison of three salivary flow rate assessment methods in an elderly population. Commun. Dent. Oral Epidemiol. 28, (2000)177–184.

    Article  CAS  Google Scholar 

  • Kikuchi M., T. Inagaki, K. Ogawa, S. Banno, Y. Matsumoto, R. Ueda, e.a. Histopathological inveastigation of salivary glands in the asymptomatic elderly. Archs Geront. Geratr. 38, (2004)131–138.

    Article  Google Scholar 

  • Kim S.K. Protein synthesis in salivary glands as related to aging. In: The Aging Mouth. Ed. D.B. Ferguson. Karger, Basel. Frontiers of Oral Physiology, vol. 6, (1987)pp.96–110.

    Google Scholar 

  • Kim S.K. en E.D. Allen. Structural and functional changes in salivary glands during aging. Microsc. Res. Techn. 28, (1994)243–253.

    Article  CAS  Google Scholar 

  • Koller M.M., R.A. Cowman, M.G. Humphreys-Beher en P.J. Scarpace. An analysis of submandibular gland function with desipramine and age in female NIA Fischer 344 rats. Mech. Ageing Dev. 119, (2000)131–147.

    Article  CAS  PubMed  Google Scholar 

  • Liu P., P.A. Denny en P.C. Denny. The effect of ageing on parenchymal cell populations in adult female mouse submandibular gland. Archs Oral Biol. 45, (2000)585–592

    Article  CAS  Google Scholar 

  • Michels L.F.E. en A. van Nieuw Amerongen. Problematiek van ouder worden en mondgezondheid. In: Geriatrische Tandheelkunde. Eds. C. de Baat en W. Kalk. 1999, Hoofdstuk 11. pp. 117–130.

    Google Scholar 

  • Mojet J., E. Christ-Hazelhof en J. Heidema. Taste perception with age: Generic or specific losses in threshold sensitivity to the five basic tastes? Chem. Senses 26, (2001)845–860.

    Article  CAS  Google Scholar 

  • Moreira C.F., L.R. Azevedo, J.R. Pereira Lauris, R. Taga en J.H. Damante. Quatitative age-related differences in human sublingual gland. Archs Oral Biol. 51, (2006)960–966.

    Article  Google Scholar 

  • Moritsuka M., Y. Kitasako, M.F. Burrow, M. Ikeda, J. Tagami en S. Nomura. Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages. J. Dent. 34, (2006)716–720.

    Article  PubMed  Google Scholar 

  • Nagler R.M. en O. Hershkovich. Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints. Aging Clin. Exptl Res. 17, (2005)358–366.

    Article  Google Scholar 

  • Närhi T.O., J.H. Meurman, A. Ainamo, J.M. Nevalainen, K.G. Schmidt-Kaunisaho, P. Siukosaari, e.a. Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86- year-old inhabitants in Helsinki, Finland. J. Dent. Res. 71, (1992)1875–1880.

    Article  PubMed  Google Scholar 

  • Närhi T.O. Prevalence of subjective feelings of dry mouth in the elderly. J. Dent. Res. 73, (1994)20–25.

    Article  PubMed  Google Scholar 

  • Närhi T.O., J. Tenovuo, A. Ainamo en P. Vilja. Antimicrobial factors, sialic acid, and protein concentration in whole saliva of the elderly. Scand. J. Dent. Res. 102, (1994)120–125.

    PubMed  Google Scholar 

  • Närhi T.O., J.H. Meurman en A. Ainamo. Xerostomia and hyposalivation. Causes, consequences and treatment in the elderly. Drugs Aging 15, (1999)103–116.

    Article  PubMed  Google Scholar 

  • Nederfors T., R. Isaksson, H. Mörnstad en C. Dahlof. Prevalence of perceived symptoms of dry mouth in an adult Swedish population – Relation to age, sex and pharmacotherapy. Commun. Dent. Oral Epidemiol. 25, (1997)211–216.

    Article  CAS  Google Scholar 

  • Pajukoski H., J.H. Meurman, P. Halonen en R. Sulkava. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases. Oral Surg.Oral Med. Oral Pathol. Oral Radiol. Endod. 92, (2001)641–649.

    Article  CAS  PubMed  Google Scholar 

  • Percival R.S., S.J. Challacombe en P.D. Marsh. Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J. Dent. Res. 73, (1994)1416–1420.

    CAS  PubMed  Google Scholar 

  • Putten G.J. van der, H.S. Brand, C.P. Bots en A. van Nieuw Amerongen. Prevalentie van xerostomie en hyposalivatie in een verpleeghuis en de relatie met voorgeschreven medicatie. Tijdschr. Gerontol. Geriatr. 34, (2003)30–36.

    PubMed  Google Scholar 

  • Scott J., E.A. Flower en J. Burns. A quantitative study of histological changes in the human parotid gland occurring with adult age. J. Oral Pathol. 16, (1987)505–510.

    Article  CAS  PubMed  Google Scholar 

  • Shern R.J., P.C. Fox en S.H. Li. Influence of age on the secretory rates of the human minor salivary glands and whole saliva. Archs Oral Biol. 38, (1993)755–761.

    Article  CAS  Google Scholar 

  • Ship J.A. en B.J. Baum. Is reduced salivary flow normal in old people? The Lancet 336, (1991)1507.

    Article  Google Scholar 

  • Ship J.A. en J.M. Weiffenbach. Age, gender, medical treatment, and medication effects on smell identification. J. Gerontol. 48, (1993)M26–M32.

    Article  CAS  PubMed  Google Scholar 

  • Ship J.A., N.E. Nolan en S.A. Puckett. Longitudinal analysis of parotid and submandibular flow rates in healthy, different-aged adults. J. Gerontol. Med. Sci. 50A, (1995)M285–M289.

    Article  Google Scholar 

  • Shugars D.C., C.A. Watkins en H.J. Cowen. Salivary concentration of secretory leukocyte protease inhibitor, an antimicrobial protein, is decreased with advanced age. Gerontology 47, (2001)246–253.

    Article  CAS  PubMed  Google Scholar 

  • Smith D.J., K. Joshipura, R. Kent en M.A. Taubman. Effect of age on immunoglobulin content and volume of human labial gland saliva. J. Dent. Res. 71, (1992)1891–1894.

    Article  CAS  PubMed  Google Scholar 

  • Spitzer M.E. Taste acuity in institutionalized and non-institutionalized elderly men. J. Gerontol. 43, (1988)71–74.

    Article  Google Scholar 

  • Sreebny L.M., A. Valdini en A. Yu. Xerostomia. Part II. Relationship to nonoral symptoms, drugs and diseases. Oral Surg. Oral Med. Oral Pathol. 68, (1989)419–427.

    Article  CAS  PubMed  Google Scholar 

  • Stewart-Knox B.J., E.E.A. Simpson, H. Parr, G. Rae, A. Polito, F. Intorre, e.a. Zinc status and taste acuity in older Europeans: the ZENITH study. Eur. J. Clin. Nutr. 59, (2005)S31–S–36.

    Article  CAS  PubMed  Google Scholar 

  • Tanida T., E. Ueta, A. Tobiume, T. Hamada, F. Rao en T. Osaki. Influence of aging on candidal growth and adhesion regulatory agents in saliva. J. Oral Pathol. Med. 30, (2001)328–335.

    Article  CAS  PubMed  Google Scholar 

  • Thomsen W.M., A.J. Spencer, G.D. Slade en J.M. Chalmers. Is medication a risk factor for dental caries among older people. Commun. Dent. Oral Epidemiol. 30, (2002)224–232.

    Article  Google Scholar 

  • Turner M.D. en J.A. Ship. Dry mouth and its effects on the oral health of elderly people. J. Am. Dental Assoc. 138, (2007)15S–20S.

    Article  Google Scholar 

  • Tylenda C.A., J.A. Ship, P.C. Fox en B.J. Baum. Evaluation of submandibular salivary flow rate in different age groups. J. Dent. Res. 67, (1988)1225–1228.

    Article  CAS  PubMed  Google Scholar 

  • Vered M., A. Buchner, P. Boldon en D. Dayan. Agerelated histomorphometric changes in labial salivary glands with special reference to the acinar component. Exptl. Gerontol. 35, (2000)1075–1084.

    Article  CAS  Google Scholar 

  • Vissink A., F.K.L. Spijkervet en A. van Nieuw Amerongen. Ageing and saliva. Spec. Care Dent. 16, (1996)95–103.

    Article  CAS  Google Scholar 

  • Vissink A., F.K.L. Spijkervet en A. van Nieuw Amerongen. Veranderingen in secretie en samenstelling van speeksel met het ouder worden. Ned. Tijdschr. Tandheelkd. 104, (1997)186–189.

    CAS  PubMed  Google Scholar 

  • Wu A.J., J.C. Atkinson, P.C. Fox, B.J. Baum en J.A. Ship. Cross-sectional and longitudinal analysis of stimulated parotid salivary constituents in healthy, different-aged subjects. J. Gerontol.: Med.Sci. 48, (1993)M219–M224.

    Article  CAS  Google Scholar 

  • Wu A.J., B.J. Baum en J.A. Ship. Extended stimulated parotid and submandibular secretion in a healthy young and old population. J. Geront. Med. Sci. 50A, (1995)M45–M48.

    Article  CAS  Google Scholar 

  • Yeh C.K., D.A. Johnson en M.W.J. Dodds. Impact of aging on human salivary gland function: A community-based study. Aging Clin. Exptl. Res. 10, (1998)421–428.

    Article  CAS  Google Scholar 

  • Yoshihara A., T. Hirotomi, N. Takano, T. Kondo en N. Hanada. Serum markers of chronic dehydration are associated with saliva spinability. J. Oral Rehabil. 34, (2007)733–738.

    Article  CAS  PubMed  Google Scholar 

  • Zussman E., A.L. Yarin en R.M. Nagler. Age- and flow-dependency of salivary viscoelasticity. J. Dent. Res. 86, (2007)281–285.

    Article  CAS  PubMed  Google Scholar 

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van Nieuw Amerongen, A. (2008). 18 Leeftijd en speeksel. In: Speeksel, speekselklieren en mondgezondheid. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-313-6317-9_18

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  • DOI: https://doi.org/10.1007/978-90-313-6317-9_18

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