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11 Speekselgroeifactoren: EGF en NGF

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Samenvatting

Uit de studies van de groeifactoren is duidelijk geworden dat de speekseleiwitten niet alleen hun functies uitoefenen in de mondholte, ten behoeve van de orale mucosa en gebitselementen, maar dat verschillende speekselcomponenten ook van essentieel belang zijn voor de differentiatie en groei van andere perifere weefsels en organen. Zij vertonen hierin een hormoonachtige werking.

Zowel EGF als NGF wordt vooral gesynthetiseerd in de gl. submandibularis van de muis. Zij bevinden zich binnen de GCT-cellen in dezelfde secretiegranules en worden gelijktijdig onder invloed van alfa-adrenerge stimuli gesecreteerd in speeksel. Opvallend is dat beide groeifactoren in een beschermde, complexe structuur worden gesecreteerd, zodat ze het transport door het maag-darmkanaal overleven en als biologisch actieve peptiden worden opgenomen in de bloedbaan. Vandaar worden ze verspreid in het lichaam en hechten aan doelcellen die een receptor bezitten op hun plasmamembraan:

  • EGF vooral op mesenchymaal en epitheelweefsel;

  • NGF vooral op sympathisch geïnnerveerde weefsels.

Beide groeifactoren stimuleren hun doelcellen tot groei en celdeling, wat vergezeld gaat van verhoogde activiteit van ornithinedecarboxylase, en van verhoogde synthese van DNA, RNA en eiwit. In adrenerge neuronen induceert NGF daarnaast nog specifiek de biosynthese van noradrenaline.

De speekselgroeifactoren EGF en NGF zijn vooral in het embryonale en neonatale stadium van groot belang voor de goede ontwikkeling en differentiatie van de doelweefsels.

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© Bohn Stafleu van Loghum, onderdeel van Springer Uitgeverij 2008

Authors and Affiliations

  1. 1.Sectie Orale BiochemieAcademisch Centrum Tandheelkunde Amsterdam (ACTA), Vrije Universiteit en Universiteit van AmsterdamAmsterdam

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