Microscale transcriptome analysis
In the previous chapter, we have analysed some important applications of RNA-seq in the neurosciences. A common feature of the described papers is that the spatial resolution of the analysed transcriptome corresponds to a brain subregion (e.g., cerebellum, cortex, hippocampus, and so on). However, this type of approach can neither discriminate the signals originating from different cell types (neurons astrocytes, other glia cells) or subtypes1 nor can account for cell-to-cell variability in gene expression.
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