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Clinical Aspects in Vascular Malformations

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Abstract

Since the turn of the last century, relentless efforts were made on the congenital vascular malformation (CVM) for better understanding. But, the CVM still remains as an enigma in modern medicine with such wide range of clinical presentation, unpredictable clinical course, and erratic response to the treatment with high recurrence: the most difficult and confusing diagnostic as well as therapeutic challenge among various vascular disorders [1–3].

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References

  1. Lee BB, Kim HH, Mattassi R, Yakes W, Loose D, Tasnadi G (2003) A new approach to the congenital vascular malformation with new concept – Seoul Consensus. Int J Angiol 12:248–251

    Google Scholar 

  2. Lee BB, Mattassi R, Loose D, Yakes W, Tasnadi G, Kim HH (2004) Consensus on controversial issues in contemporary diagnosis and management of congenital vascular malformation – Seoul communication. Int J Angiol 13(4):182–192

    Google Scholar 

  3. Lee BB (2008) Changing concept on vascular malformation: no longer enigma. Ann Vasc Dis 1(1):11–19

    Article  PubMed Central  PubMed  Google Scholar 

  4. Malan E, Puglionisi A (1965) Congenital angiodysplasias of the extremities, note II: arterial, arterial and venous, and hemolymphatic dysplasias. J Cardiovasc Surg (Torino) 6:255–345

    CAS  Google Scholar 

  5. Malan E (1974) History and nosography. In: Malan E (ed) Vascular malformations (angiodysplasias). Carlo Erba Foundation, Milan, pp 15–19

    Google Scholar 

  6. Villavicencio JL (2007) Congenital vascular malformations: historical background. Special issue. Phlebology 22:247–248

    Article  CAS  PubMed  Google Scholar 

  7. Mulliken JB (1988) Treatment of hemangiomas. In: Mulliken JB, Young AE (eds) Vascular birthmarks, hemangiomas and malformations. WB Saunders, Philadelphia, pp 88–90

    Google Scholar 

  8. Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69:412–422

    Article  CAS  PubMed  Google Scholar 

  9. Mulliken JB (1988) Classification of vascular birthmarks. In: Grainger RG, Allison DJ (eds) Vascular birthmarks, haemangiomas, and malformations. WB Saunders, Philadelphia, pp 24–37

    Google Scholar 

  10. Lee BB (2002) Advanced management of congenital vascular malformation (CVM). Int Angiol 21(3):209–213

    CAS  PubMed  Google Scholar 

  11. Lee BB (2004) Critical issues on the management of congenital vascular malformation. Ann Vasc Surg 18(3):380–392

    Article  CAS  PubMed  Google Scholar 

  12. Lee BB, Laredo J (2012) Hemangioma and venous/vascular malformation are different as an apple and orange! Editorial. Acta Phlebol 13:1–3

    Google Scholar 

  13. Lee BB, Laredo J, Lee TS, Huh S, Neville R (2007) Terminology and classification of congenital vascular malformations. Phlebology 22(6):249–252

    Article  CAS  PubMed  Google Scholar 

  14. Bastide G, Lefebvre D (1989) Anatomy and organogenesis and vascular malformations. In: Belov S, Loose DA, Weber J (eds) Vascular malformations. Einhorn-Presse Verlag GmbH, Reinbek, pp 20–22

    Google Scholar 

  15. Woolard HH (1922) The development of the principal arterial stems in the forelimb of the pig. Contrib Embryol 14:139–154

    Google Scholar 

  16. Lee BB (2013) Venous malformation and haemangioma: differential diagnosis, diagnosis, natural history and consequences. Phlebology 28(Suppl 1):176–187

    Article  PubMed  Google Scholar 

  17. Lee BB, Lardeo J, Neville R (2009) Arterio-venous malformation: how much do we know? Phlebology 24:193–200

    Article  CAS  PubMed  Google Scholar 

  18. Lee BB, Laredo J (2012) Classification of congenital vascular malformations: the last challenge for congenital vascular malformations. Phlebology 27(6):267–269

    Article  CAS  PubMed  Google Scholar 

  19. Lee BB (2012) Venous embryology: the key to understanding anomalous venous conditions. Phlebolymphology 19(4):170–181

    Google Scholar 

  20. Lee BB (2012) Venous malformation is NOT a hemangioma. Editorial. Flebologia Y Linfologia – Lecturas Vasculares 7(17):1021–1023

    Google Scholar 

  21. Lee BB, Laredo J (2013) Venous malformation: treatment needs a bird’s eye view. Phlebology 28:62–63

    Article  PubMed  Google Scholar 

  22. Lee BB (2012) Klippel-Trenaunay syndrome: is this term still worthy to use? Acta Phlebol 13:1–2

    Google Scholar 

  23. Klippel M, Trenaunay J (1900) Du noevus variqueux et osteohypertrophique. Arch Gén Méd 3:641–672

    Google Scholar 

  24. Gloviczki P, Driscoll DJ (2007) Klippel–Trenaunay syndrome: current management. Phlebology 22:291–298

    Article  CAS  PubMed  Google Scholar 

  25. Belov S (1990) Classification of congenital vascular defects. Int Angiol 9:141–146

    CAS  PubMed  Google Scholar 

  26. Belov S (1993) Anatomopathological classification of congenital vascular defects. Semin Vasc Surg 6:219–224

    CAS  PubMed  Google Scholar 

  27. Belov S (1989) Classification, terminology, and nosology of congenital vascular defects. In: Belov S, Loose DA, Weber J (eds) Vascular malformations. Einhorn-Presse, Reinbek, pp 25–30

    Google Scholar 

  28. Lee BB, Laredo J, Lee SJ, Huh SH, Joe JH, Neville R (2007) Congenital vascular malformations: general diagnostic principles. Phlebology 22(6):253–257

    Article  CAS  PubMed  Google Scholar 

  29. Lee BB, Bergan J, Gloviczki P, Laredo J, Loose DA, Mattassi R, Parsi K, Villavicencio JL, Zamboni P (2009) Diagnosis and treatment of venous malformations - consensus document of the International Union of Phlebology (IUP)-2009. Int Angiol 28(6):434–451

    CAS  PubMed  Google Scholar 

  30. Lee BB, Choe YH, Ahn JM, Do YS, Kim DI, Huh SH, Byun HS (2004) The new role of MRI (magnetic resonance imaging) in the contemporary diagnosis of venous malformation: can it replace angiography? J Am Coll Surg 198(4):549–558

    Article  PubMed  Google Scholar 

  31. Lee BB. Not all venous malformations needed therapy because they are not arteriovenous malformations. Comments on Dermatol Surg. 2010;36(3):340–346. Dermatol Surg. 2010;36(3):347

    Google Scholar 

  32. Lee BB, Bergan JJ (2002) Advanced management of congenital vascular malformations: a multidisciplinary approach. J Cardiovasc Surg 10(6):523–533

    Article  Google Scholar 

  33. Lee BB, Do YS, Yakes W, Kim DI, Mattassi R, Hyun WS, Byun HS (2004) Management of arterial-venous shunting malformations (AVM) by surgery and embolosclerotherapy. A multidisciplinary approach. J Vasc Surg 3:596–600

    Google Scholar 

  34. Lee BB (2003) Current concept of venous malformation (VM). Phlebolymphology 43:197–203

    Google Scholar 

  35. Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH (2003) Advanced management of venous malformation (VM) with ethanol sclerotherapy: mid-term results. J Vasc Surg 37(3):533–538

    Article  CAS  PubMed  Google Scholar 

  36. Lee BB, Bergan J (2008) Chapter 12. Transition from alcohol to foam sclerotherapy for localized venous malformation with high risk. In: Bergan J, Cheng VL (eds) A textbook- foam sclerotherapy. The Royal Society of Medicine Press Ltd, London, pp 129–139

    Google Scholar 

  37. Lee BB, Villavicencio JL (2010) Primary lymphedema and lymphatic malformation: are they the two sides of the same coin? Eur J Vasc Endovasc Surg 39:646–653

    Article  CAS  PubMed  Google Scholar 

  38. Lee BB, Andrade M, Bergan J, Boccardo F, Campisi C, Damstra R, Flour M, Gloviczki P, Laredo J, Piller N, Michelini S, Mortimer P, Villavicencio JL (2010) Diagnosis and treatment of primary lymphedema – consensus document of the International Union of Phlebology (IUP)-2009. Int Angiol 29(5):454–470

    CAS  PubMed  Google Scholar 

  39. Lee BB, Kim YW, Seo JM, Hwang JH, Do YS, Kim DI, Byun HS, Lee SK, Huh SH, Hyun WS (2005) Current concepts in lymphatic malformation (LM). Vasc Endovasc Surg 39(1):67–81

    Article  CAS  Google Scholar 

  40. Kim JY, Kim DI, Do YS, Kim YW, Lee BB (2006) Surgical treatment for congenital arteriovenous malformation: 10 years’ experience. Eur J Vasc Endovasc Surg 32(1):101–106, Epub 2006 Feb

    Article  CAS  PubMed  Google Scholar 

  41. Lee BB, Laredo J, Deaton DH, Neville RF (2009) Chapter 53. Arteriovenous malformations: evaluation and treatment. In: Gloviczki P, Hodder Arnold A, Gloviczki P (eds) Handbook of venous disorders: guidelines of the American Venous Forum, 3rd edn. A Hodder Arnold, London, pp 583–593

    Google Scholar 

  42. Lee BB (2006) Chapter 76. Mastery of vascular and endovascular surgery. In: Zelenock GB, Huber TS, Messina LM, Lumsden AB, Moneta GL (eds) Arteriovenous malformation. Lippincott, Williams and Wilkins, Philadelphia, pp 597–607

    Google Scholar 

  43. Lee BB (2005) New approaches to the treatment of congenital vascular malformations (CVMs) – single center experiences – (editorial review). Eur J Vasc Endovasc Surg 30(2):184–197

    Article  CAS  PubMed  Google Scholar 

  44. Lee BB, Laredo J, Kim YW, Neville R (2007) Congenital vascular malformations: general treatment principles. Phlebology 22(6):258–263

    Article  CAS  PubMed  Google Scholar 

  45. Lee BB, Laredo J, Seo JM, Neville R (2009) Chapter 29. Treatment of lymphatic malformations. In: Mattassi R, Loose DA, Vaghi M (eds) Hemangiomas and vascular malformations. Springer Italia, Milan, pp 231–250

    Chapter  Google Scholar 

  46. Villavicencio JL, Scultetus A, Lee BB (2002) Congenital vascular malformation: when and how to treat them. Semin Vasc Surg 15(1):65–71

    Article  PubMed  Google Scholar 

  47. Kim KH, Kim HH, Lee SK, Seo JM, Lee BB, Chang WY (2001) OK-432 intralesional therapy for lymphangioma in children. J Korean Assoc Pediatr Surg 7(2):142–146

    Google Scholar 

  48. Lee BB, Baumgartner I, Berlien HP, Bianchini G, Burrows P, Do YS, Ivancev K, Kool LS, Laredo J, Loose DA, Lopez-Gutierrez JC, Mattassi R, Parsi K, Rimon U, Rosenblatt M, Shortell C, Simkin R, Stillo F, Villavicencio L, Yakes W (2013) Consensus document of the International Union of Angiology (IUA)-2013. Current concept on the management of arterio-venous management. Int Angiol 32(1):9–36

    CAS  PubMed  Google Scholar 

  49. Lee BB, Mattassi R, Choe YH et al (2005) Critical role of duplex ultrasonography for the advanced management of a venous malformation (VM). Phlebology 20:28–37

    Article  Google Scholar 

  50. Lee BB (2013) Marginal vein is not a simple varicose vein: it is a silent killer! Review. Damar Cer Derg 22(1):4–14

    Article  Google Scholar 

  51. Lee BB, Laredo J, Neville R, Mattassi R (2011) Chapter 52. Primary lymphedema and Klippel-Trenaunay syndrome. Section 11 – lymphedema and congenital vascular malformation. In: Byung-Boong L, Bergan J, Rockson SG (eds) Lymphedema: a concise compendium of theory and practice, 1st edn. Springer, London, pp 427–436

    Google Scholar 

  52. Loose DA, Weber J (1991) Indications and tactics for a combined treatment of congenital vascular malformations. In: Balas P (ed) Progress in angiology. Chapt Miscellanea. Minerva Medica, Torino, pp 379–482

    Google Scholar 

  53. Loose DA (2009) Combined treatment of arteriovenous malformations. In: Mattassi R, Loose DA, Vaghi M (eds) Hemangiomas and vascular malformations. Springer, Milan, pp 195–204

    Chapter  Google Scholar 

  54. Yakes WF, Parker SH, Gibson MD, Haas DK, Pevsner PH, Carter TE (1989) Alcohol embolotherapy of vascular malformations. Semin Intervent Radiol 6:146–161

    Article  Google Scholar 

  55. Cromwell LD, Kerber CW (1979) Modification of cyano-acrylate for therapeutic embolization: preliminary experience. Am J Roentgenol 132:799

    Article  CAS  Google Scholar 

  56. Weber JH (1993) Vaso-occlusive angiotherapy (VAT) in congenital vascular malformations. Semin Vasc Surg 6:279–296

    CAS  PubMed  Google Scholar 

  57. Natali J, Merland JJ (1976) Superselective arteriography and therapeutic embolization for vascular malformations (angiodysplasias). J Cardiovasc Surg 17:465–472

    CAS  Google Scholar 

  58. Lee BB (1999) Congenital venous malformation: changing concept on the current diagnosis and management. Asian J Surg 22(2):152–154

    Google Scholar 

  59. Lee BB, Kim DI, Huh S, Kim HH, Choo IW, Byun HS, Do YS (2001) New experiences with absolute ethanol sclerotherapy in the management of a complex form of congenital venous malformation. J Vasc Surg 33(4):764–772

    Article  CAS  PubMed  Google Scholar 

  60. Mattassi R (1993) Differential diagnosis in congenital vascular-bone syndromes. Semin Vasc Surg 6:233–244

    CAS  PubMed  Google Scholar 

  61. Kim YW, Do YS, Lee SH, Lee BB (2006) Risk factors for leg length discrepancy in patients with congenital vascular malformation. J Vasc Surg 44:545–553

    Article  PubMed  Google Scholar 

  62. Mattassi R, Vaghi M (2007) Vascular bone syndrome-angi-osteodystrophy: current concept. Phlebology 22:287–290

    Article  CAS  PubMed  Google Scholar 

  63. Mattassi R, Vaghi M (2007) Management of the marginal vein: current issues. Phlebology 22:283–286

    Article  CAS  PubMed  Google Scholar 

  64. Aggarwal K, Jain VK, Gupta S, Aggarwal HK, Sen J, Goyal V (2003) Klippel-Trenaunay syndrome with a life-threatening thromboembolic event. J Dermatol 30(3):236–240

    Article  PubMed  Google Scholar 

  65. Walder B, Kapelanski DP, Auger WR, Fedullo PF (2000) Successful pulmonary thromboendarterectomy in a patient with Klippel-Trenaunay syndrome. Chest 117(5):1520–1522

    Article  CAS  PubMed  Google Scholar 

  66. Villavicencio JL, Conaway CW, Pikoulis E, Gannon MX (1997) Congenital vascular malformations of venous predominance. The Klippel Trenaunay syndrome. In: Raju S, Villavicencio JL (eds) Surgical management of venous disease. Williams and Wilkins, Media, pp 445–467

    Google Scholar 

  67. Jacob AG, Driscoll DJ, Shaughnessy WJ, Stanson AW, Clay RP, Gloviczki P (1998) Klippel-Trenaunay syndrome: spectrum and management. Mayo Clin Proc 73(1):28–36

    Article  CAS  PubMed  Google Scholar 

  68. Gloviczki P, Stanson AW, Stickler GB, Johnson CM, Toomey BJ, Meland NB, Rooke TW, Cherry KJ Jr (1991) Klippel-Trenaunay syndrome: the risks and benefits of vascular interventions. Surgery 110(3):469–479

    CAS  PubMed  Google Scholar 

  69. Lee BB, Kim DI, Kim HH, Choi JY, Do YS, Choo SW, Kim BT (2000) Hidden risk of the deterioration of the lymphatic function following the management of venous component of the hemolymphatic malformation (HLM). Abstract, 13th International Society for the Study of Vascular Anomalies, Montreal, May 10–13, 2000

    Google Scholar 

  70. al-Salman MM (1997) Klippel-Trenaunay syndrome: clinical features, complications, and management. Surg Today 27(8):735–740

    Article  CAS  PubMed  Google Scholar 

  71. Servelle M, Babillot J (1980) Deep vein malformations in the Klippel-Trenaunay syndrome. Phlebologie 33(1):31–36

    CAS  PubMed  Google Scholar 

  72. Kim YW, Lee BB, Cho JH, Do YS, Kim DI, Kim ES (2007) Haemodynamic and clinical assessment of lateral marginal vein excision in patients with a predominantly venous malformation of the lower extremity. Eur J Vasc Endovasc Surg 33(1):122–127

    Article  PubMed  Google Scholar 

  73. Eifert S, Villavicencio JL, Kao TC et al (2000) Prevalence of deep venous anomalies in congenital vascular malformations of venous predominance. J Vasc Surg 31:462–471

    Article  CAS  PubMed  Google Scholar 

  74. Telander RL, Kaufman BH, Gloviczki P, Stickler GB, Hollier LH (1984) Prognosis and management of lesions of the trunk in children with Klippel-Trenaunay syndrome. J Pediatr Surg 19(4):417–422

    Article  CAS  PubMed  Google Scholar 

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Lee, BB., Laredo, J., Neville, R.F. (2015). Clinical Aspects in Vascular Malformations. In: Mattassi, R., Loose, D., Vaghi, M. (eds) Hemangiomas and Vascular Malformations. Springer, Milano. https://doi.org/10.1007/978-88-470-5673-2_24

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