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Immunoglobulin as Adjunctive Therapy in Sepsis

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Anaesthesia, Pharmacology, Intensive Care and Emergency A.P.I.C.E.


Mortality in patients admitted to hospital with severe sepsis and septic shock is still unacceptably high, despite advances in understanding of the pathophysiological mechanisms and the implementation of evidence-based guidelines. Severe sepsis is often associated with the decrease in immunoglobulin plasma levels (Ig) and the presence of hypogammaglobulinaemia is related to bad outcome. Ig plays a pivotal role in immune and inflammatory response and therapy with intravenous Ig is currently recommended in several no septic diseases. Diverse meta-analysis showed that the adjunctive therapy with intravenous polyclonal Ig, particularly with preparation enriched in IgM component, may be beneficial also in patients with severe sepsis and septic shock.

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SSC =:

Surviving Sepsis Campaign

ICU =:

Intensive Care Unit


Systemic Inflammatory Response Syndrome

IgG/IgM =:

Immunoglobulin G/M

IgGAM =:

Immunoglobulin IgM enriched

SSP =:

Sepsis Stewardship Program


Sequential Organ Failure Assessment


Simplified Acute Physiology Score

RCT =:

Randomized Controlled Trial

CVP =:

Central Venous Pressure

SvcO2 =:

Central Venous Oxygen Saturation

ALI =:

Acute Lung Injury


Acute Respiratory Distress Syndrome

rhAPC =:

recombinant human Activated C Protein


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Correspondence to Massimo Girardis .

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Girardis, M., Serafini, G., Cavazzuti, I. (2014). Immunoglobulin as Adjunctive Therapy in Sepsis. In: Gullo, A. (eds) Anaesthesia, Pharmacology, Intensive Care and Emergency A.P.I.C.E.. Springer, Milano.

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