Abstract
Behçet’s syndrome (BS) shows characteristic genital ulceration. The endocrine, vascular, and immunological changes that occur in pregnancy produce local modification. BS in pregnancy can be exacerbated and specific lesions can erupt, but generally the disease course is unpredictable and variable from one patient to another. Clinical and therapeutic managements are described below.
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Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Gonçalves O, Valente J (2009) Behçet’s disease-a contemporary review. J Autoimmun 32(3–4):178–188 Epub 2009 Mar 26
Bluthe L (1908) Zur kenntnis des recidiverenden hypopyons. Inaugural Thesis, Heidelberg
Behçet H (1937) Uber rez idivierende, aphthose, durch ein virus verursachte Geschwure am Munde, am Auge und an Genitalien. Dermatol Wochenschr 105:1152–1157
Jadaon J, Shushan A, Ezra Y, Sela HY, Ozcan C, Rojansky N (2005) Behçet’s disease and pregnancy. Acta Obstet Gynecol Scand 84(10):939–944
Davatchi F, Shahram F, Davatchi CC, Shams H, Nadji A, Akhlaghi M, Faezi T, Ghodsi Z, Faridar A, Ashofteh F, Sadeghi AB, Sollahi B (2010) Behçet’s disease: from East to West. Clin Rheumatol 29(8):823–833 Review
Zouboulis CC (1999) Epidemiology of Adamantiades-Behçet’s disease. Ann Med Interne 150:488–498
Al-Otaibi LM, Porter SR, Poate TW (2005) Behçet’s disease: a review. J Dent Res 84(3):209–222 Review
Alpsoy E, Durusoyn C, Yilmaz E, Özgürel Y, Ermis O, Yazar S, Basaran E (2002) Interferon alpha-2a in the treatment of Behçet’s disease: a rando mized, placebo-controlled and double-blind study. Arch Dermatol 138(467):7.1
Chajek T, Fainaru M (1975) Behçet’s disease: report of 41 cases and a review of the literature. Medicine (Baltimore) 54:179–196
Ghate JV, Jorizzo JL (1999) Behçet’s disease and complex aphtosis. J Am Acad Dermatol 40:1–18
Schreiner DT, Jorizzo JL (1987) Behçet’s disease and complex aphtosis. Dermatol Clin 5:769–778
Kontogiannis V, Powell RJ (2000) Behçet’s disease. Postgrad Med J 76:629–637
Marshall SE (2004) Behçet’s disease. Best Pract Res Clin Rheumatol 18(3):291–311
Arbesfeld SJ, Kurban AK (1988) Behçet’s disease: new perspectives on an enigmatic syndrome. J Am Acad Dermatol 19:767–779
Stratigos AJ, Laskaris G, Stratigos JD (1992) Behçet’s disease. Semin Neurol 12:346–357
Alpsoy E, Zouboulis CC, Ehrlich GE (2007) Mucocutaneous lesions of Behçet’s disease. Yonsei Med J 48(4):573–585 Review
Aktulga E et al (1980) A double blind study of colchicine in Behçet’s disease. Haematologica 65:399–402
Yurdakul S, Mat C, Tüzün Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H (2001) A double-blind trial of colchicine in Behçet’s syndrome. Arthritis Rheum 44(11):2686–2692
Mat C et al (2006) A double-blind trial of depot corticosteroids in Behçet’s syndrome. Rheumatology (Oxford) 45:348–352
Yazici H, Pazarli H, Barnes CG, Tüzün Y, Ozyazgan Y, Silman A, Serdaroğlu S, Oğuz V, Yurdakul S, Lovatt GE et al (1990) A controlled trial of azathioprine in Behçet’s syndrome. N Engl J Med 322(5):281–285
Jorizzo JL, White WL, Wise CM, Zanolli MD, Sherertz EF (1991) Low-dose weekly methotrexate for unusual neutrophilic vascular reactions: cutaneous polyarteritis nodosa and Behçet’s disease. J Am Acad Dermatol 24(6 Pt 1):973–978
Avci O, Gürler N, Güneş AT (1997) Efficacy of cyclosporine on mucocutaneous manifestations of Behçet’s disease. J Am Acad Dermatol 36(5 Pt 1):796–797
Masuda K et al (1989) Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet’s disease. Lancet 1:1093–1096
Sharquie KE (1984) Suppression of Behçet’s disease with dapsone. Br J Dermatol 110(4):493–494
Hamuryudan V, Mat C, Saip S, Ozyazgan Y, Siva A, Yurdakul S, Zwingenberger K, Yazici H (1998) Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 128(6):443–450
Katsantonis J, Seltmann H, Wrobel A, Adler YD, Hornemann S, Orfanos CE et al (2001) Xenobiotic regulation of endothelial intracellular and secreted interleukin-8 induced by serum of patients with Adamantiades–Behçet’s disease. In: Bang D, Lee E-S, Lee S (eds) Behçet’s Disease. Proceedings of the 8th and the 9th international conference on Behçet’s Disease Seoul: library of congress cataloging, pp 236–239
Zouboulis CC, Orfanos CE (1998) Treatment of Adamantiades-Behçet disease with systemic interferon alfa. Arch Dermatol 134(8):1010–1016
Goossens PH, Verburg RJ, Breedveld FC (2001) Remission of Behçet’s syndrome with tumour necrosis factor alpha blocking therapy. Ann Rheum Dis 60(6):637
Robertson LP, Hickling P (2001) Treatment of recalcitrant orogenital ulceration of Behçet’s syndrome with infliximab. Rheumatology (Oxford) 40(4):473–474
Travis SP, Czajkowski M, McGovern DP, Watson RG, Bell AL (2001) Treatment of intestinal Behçet’s syndrome with chimeric tumour necrosis factor alpha antibody. Gut 49(5):725–728
Uzun S, Alpsoy E, Durdu M et al (2003) The clinical course of Behçet’s disease in pregnancy: a retrospective analysis and review of the literature. J Dermatol 30:499–502
Bang D, Chun YS, Haam IB et al (1997) The influence of pregnancy on Behçet’s disease. Yonsei Med J 38:437–443
Noel N, Wechsler B, Nizard J, Chalumeau NC, Boutin LD, Dommergues M, Brouzes DV, Cacoub P, Saadoun D (2013) Behcet’s disease and pregnancy. Arthritis Rheumatol
Seo P (2007) Pregnancy and vasculitis. Rheum Dis Clin North Am 33(2):299–317 Review
Torgerson RR, Marnach ML, Bruce AJ, Rogers RS (2006) Oral and vulvar changes in pregnancy. Clin Dermatol 24(2):122–132
Wechsler B, Généreau T, Biousse V, Brouzes DV, Seebacher J, Dormont D, Godeau P (1995) Pregnancy complicated by cerebral venous thrombosis in Behçet’s disease. Am J Obstet Gynecol 173(5):1627–1629
Komaba H, Takeda Y, Fukagawa M (2007) Extensive deep vein thrombosis in a postpartum woman with Behçet’s disease associated with nephrotic syndrome. Kidney Int 71(1):6
Hiwarkar P, Stasi R, Sutherland G, Shannon M (2010) Deep vein and intracardiac thrombosis during the post-partum period in Behçet’s disease. Int J Hematol 91(4):679–686
Hwang I, Lee CK, Yoo B, Lee I (2009) Necrotizing villitis and decidual vasculitis in the placentas of mothers with Behçet disease. Hum Pathol 40(1):135–138
Whitacre CC, Reingold SC, O’Loorey PA (1999) A gender gap in autoimmunity. Science 283:1277–1278
Landers DV, Bronson RA, Pavia CS (1991) Reproductive immunology. In: Stites DP (ed) Basic and clinical immunology. Prentice Hall International Inc, East Norwalk, pp 91–120
Krause PJ, Ingardia CJ, Pontius LT (1987) Host defense during pregnancy: neutrophil chemotaxis and adherence. Am J Obstet Gynecol 157:274–275
Espinosa G, Cervera R, Reverter JC, Tassies D, Font J, Ingelmo M (2002) Vascular involvement in Behçet’s disease. Isr Med Assoc J 4:614–616
Krause I, Weinberger A (2002) Vasculo–Behçet’s disease. Isr Med Assoc J 4:636–637
Langford CA, Kerr GS (2002) Pregnancy in vasculitis. Curr Opin Rheumatol 14:36–41
Belo L, Silva AS, Rocha S et al (2005) Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur J Obstet Gynecol Reprod Biol 123:46–51
Branch DW (1992) Physiologic adaptations of pregnancy. AmJ Reprod Immunol 28:120–122
Cetinkaya R, Odabas AR, Gursan N et al (2002) Microscopic polyangiitis in a pregnant woman. South Med J 95:1441–1443
Hiyama J, Shiota Y, Marukawa M et al (2000) Churg-Strauss syndrome associated with pregnancy. Intern Med 39:985–990
Lima F, Buchanan N, Froes L et al (1995) Pregnancy in granulomatous vasculitis. Ann Rheum Dis 54:604–606
Del Corso L, De Marco S, Vannini A et al (1993) Takayasu’s arteritis: low corticosteroid dosage and pregnancyda case report. Angiology 44:827–831
Nabil H, Zayed A, State O, Badawy A (2012) Pregnancy outcome in women with familial Mediterranean fever. J Obstet Gynaecol 32(8):756–759. doi:10.3109/01443615.2012.698667
Petri M (2003) Immunosuppressive drug use in pregnancy. Autoimmunity 36:51–56
Uribe MO, Gilliot C, Jung G et al (2006) Administration of rituximab during the first trimester of pregnancy without consequences for the newborn. J Perinatol 26:252–255
Merlob P, Stahl B, Klinger G (2009) Tetrada of the possible mycophenolate mofetil embryopathy: a review. Reprod Toxicol 28:105–108
Ali YM, Kuriya B, Orozco C, Cush JJ, Keystone EC (2010) Can tumor necrosis factor inhibitors be safely used in pregnancy? J Rheumatol 37:9–17
Roux CH, Brocq O, Breuil V et al (2006) Pregnancy in rheumatology patients exposed to anti-tumour necrosis factor (TNF)-{alpha} therapy. Rheumatology (Oxford) 46(4):695–698
Acknowledgments
To Dr. De Magnis Angelina for scientific support in description of genital ulcer.
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Coccia, M.E., Capezzuoli, T. (2014). Behçet’s Syndrome and Gynecological Manifestation in Reproductive Age and Pregnancy. In: Emmi, L. (eds) Behçet's Syndrome. Rare Diseases of the Immune System. Springer, Milano. https://doi.org/10.1007/978-88-470-5477-6_14
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DOI: https://doi.org/10.1007/978-88-470-5477-6_14
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