• Giuseppe TridenteEmail author


Adalimumab (Humira®, Abbott) is a recombinant fully human IgG1/2 k anti-TNFα monoclonal antibody approved in 2002 by FDA and in 2003 by EMEA (simultaneous submission). During the following years this monoclonal spread over 62 countries to be used in a wide series of immune-mediated inflammatory diseases (IMID). Initially indicated for the treatment of rheumatoid arthritis (RA), between 2005 and 2008 it was progressively extended to psoriasic arthritis (PsA), ankylosing spondylitis (AS), Crohn’s disease (CD), plaque psoriasis (Ps), and juvenile idiopathic arthritis (JIA). During 2012, adalimumab was also approved by EMEA for the treatment of ulcerative colitis (UC) and for moderate forms of CD and other inflammatory bowel diseases (IBD) in adult patients. Other approvals regarding extended applications of previously authorized diseases treatments are pending. Up to 2012, over 70 trials were performed for the six official therapeutic indications, including pivotal trials submitted for drug approvals. Overall, most data come from RA studies (over 14,000 subjects), followed by the more recent ones on CD and Psoriasis (over 3,000 subjects each) stimulated by the possibility of an extension of the treatment to these patients.


Ankylose Spondylitis Juvenile Idiopathic Arthritis Juvenile Idiopathic Arthritis Patient Erythema Multiforme Hidradenitis Suppurativa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

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Supplementary material 1 (XLS 75 kb)


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© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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