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Monoclonal Antibodies

  • Giuseppe Tridente
Chapter

Abstract

Since their initial production, Monoclonal Antibodies (monospecific clone-derived antibodies, shortly mAbs) have first expanded as outstanding laboratory tools for research and then as highly valuable therapeutic agents.

Keywords

Paroxysmal Nocturnal Hemoglobinuria Human Therapy Murine mAbs International Nonproprietary Name Heavy Chain Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Reichert JM (2013) Which are the antibodies to watch in 2013? MAbs 5:1–4PubMedCrossRefGoogle Scholar
  2. 2.
    Stroh WR and Stroh LM (2012) Therapeutic antibody engineering. Woodhead Pub Ltd. (ISBN 10:1907568379)Google Scholar
  3. 3.
    Carter PJ (2011) Introduction to current and future protein therapeutics: a protein engineering perspective. Exp Cell Res 317:1261–1269PubMedCrossRefGoogle Scholar
  4. 4.
    Nelson AL, Dhimolea E, Reichert JM (2010) Development trends for human monoclonal antibody therapeutics. Nat Rev (drug disc) 9:767–774CrossRefGoogle Scholar
  5. 5.
    Getts DR, Getts MT, McCarthy DP (2010) Have we overestimated the benefit of human(ized) antibodies? MAbs 2:682–694PubMedCrossRefGoogle Scholar
  6. 6.
    WHO (2009) General policies for monoclonal antibodies. INN Working document 09.251, June 2009, (http://www.who.int/medicines/services/inn/en/index.html)
  7. 7.
    Lanfranc M-P (2011) Antibody nomenclature from IGMT-Ontology to INN definition. MAbs 3:1–2CrossRefGoogle Scholar
  8. 8.
    Ying WY, Foote J (2005) Immunogenicity of engineered antibodies. Methods 36:3–10CrossRefGoogle Scholar
  9. 9.
    Park JW, Stolen J (2001) Monoclonal antibody therapy. In: Scolnick EM (ed) Drug discovery and design, vol 56. Academic Press, Waltham, p 375CrossRefGoogle Scholar
  10. 10.
    Ire Corey (2010) Stability of IgG isotypes in serum. MAbs 2:221–232CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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