• Giuseppe Tridente


Ipilimumab (Yervoy®, BMS), previously known as MDX-010 or BMS-734016, is a fully human IgG1k directed to the extracellular domain of CTLA-4 (cytotoxic T cell antigen-4, or CD152) present on activated T cells [1, 2, 3, 4, 5]. FDA licensed the product for the treatment of unresectable or metastatic melanoma (mMM) in 2011. During the same year, EMEA granted approval for the treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapy. Meanwhile, TGA (Australia) granted approval for the treatment of patients with advanced melanoma in whom previous therapies failed or were not tolerated. However, at that time, NICE recommended the UK National Health Service against using ipilimumab, due to lack of biomarkers (the drug was found active only in part of the patients), and due to the severity of potential AEs. In 2012, Health Canada indicated ipilimumab for the treatment of patients with unresectable or metastatic melanoma in whom other systemic therapy for advanced disease failed or were not tolerated.


Metastatic Melanoma Adrenal Insufficiency Toxic Epidermal Necrolysis Intestinal Perforation Ocular Melanoma 
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Supplementary material

307171_1_En_25_MOESM1_ESM.xls (66 kb)
Supplementary material 1 (XLS 67 kb)


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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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