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Golimumab

  • Giuseppe Tridente
Chapter

Abstract

Golimumab (Simponi®, Janssen) is a human IgG1k monoclonal antibody directed to human tumor necrosis factor alpha (TNF-α), preventing the binding of TNF-α to its receptors. In 2009, FDA approved golimumab for the treatment of the following pathologies: (i) moderately to severely active rheumatoid arthritis (RA) in adults, in combination with methotrexate (MTX); (ii) active psoriatic arthritis (PsA) in adults, alone or in combination with MTX; (iii) active ankylosing spondylitis in adults (AS). In 2009 also EMEA and Health Canada granted approval for the same indications. The national Japanese Agency PMDA approved the marketing on September 2011.

Keywords

Tumor Necrosis Factor Rheumatoid Arthritis Patient Tumor Necrosis Factor Inhibitor Injection Site Reaction Cutaneous Lupus Erythematosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

307171_1_En_22_MOESM1_ESM.xls (60 kb)
Supplementary material 1 (XLS 61 kb)

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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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