• Giuseppe Tridente


Certolizumab-pegol (Cimzia®, UCB) is a recombinant humanized Fab fragment composed of a single light and heavy chain derived from a murine IgG2a antibody, conjugated to polyethylene glycol (PEG2MAL40 K). This Fab, produced in E. Coli and subsequently linked to PEG, is directed to soluble and membrane-bound human TNFα, and inhibits its binding to p55 (TNFR1) and p75 (TNFR2) receptors, but it does not neutralize TNFβ.


Rheumatoid Arthritis Tumor Necrosis Factor Rheumatoid Arthritis Patient Optic Neuritis Injection Site Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

307171_1_En_14_MOESM1_ESM.xls (75 kb)
Supplementary material 1 (XLS 76 kb)


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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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