• Giuseppe TridenteEmail author


Catumaxomab (Removab®, Fresenius) is a trifunctional rat-mouse hybrid monoclonal antibody co-binding to the epithelial cell adhesion molecule (EpCAM) and to CD3 antigen. The double epitope specificity allows in forcing the interaction between cancer cells expressing EpCAM, and activated T cells. The third binding via the Fc-region of catumaxomab with Fcγ receptors allows direct involvement of immune accessory cells in killing the target.


Ovarian Cancer Systemic Inflammatory Response Syndrome Peritoneal Carcinomatosis Malignant Ascites Epithelial Cell Adhesion Molecule 
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Supplementary material

307171_1_En_13_MOESM1_ESM.xls (60 kb)
Supplementary material 1 (XLS 61 kb)


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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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