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Brentuximab

  • Giuseppe TridenteEmail author
Chapter

Abstract

Brentuximab vedotin (Adcetris™, Seattle Genetics; Takeda) is a chimeric IgG1k monoclonal antibody conjugated to the cytotoxic agent monomethyl auristatin E (MMAE). The complex (BV), targeting specifically CD30 (Ki-1 Ag; TNFRSF8), received an accelerated approval by FDA in 2011 for the treatment of relapsed Hodgkin’s lymphoma (HL), after failure of autologous stem cells transplantation (ASCT) or after at least two unsuccessful multiagent chemotherapy regimens in patients who are not candidates for ASCT. BV was also indicated for systemic anaplastic large cell lymphoma (sALCL) in post-chemotherapy relapse.

Keywords

Progressive Multifocal Leukoencephalopathy Autologous Stem Cell Transplantation Infusion Reaction Mycosis Fungoides Progressive Multifocal Leukoencephalopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

307171_1_En_11_MOESM1_ESM.xls (72 kb)
Supplementary material 1 (XLS 73 kb)

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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.University of VeronaVeronaItaly

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