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Well-Differentiated Carcinomas of the Thyroid Gland and Neoplasms of the Parathyroid Glands

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What’s New in Surgical Oncology

Abstract

Papillary carcinoma and follicular thyroid carcinoma, called well-differentiated carcinomas (WDCs) of the thyroid gland, account for ≈1% of human cancers, with an incidence between 0.5 and 10 per 100,000 per year, and increasing steadily. The increasing incidence is probably due to the early diagnosis of the subclinical disease (i.e., of papillary microcarcinomas) even though the SEER analysis conducted in 2009 by the National Cancer Institute showed an increase in well-differentiated tumors of the thyroid gland irrespective of size, including tumors > 4 cm in diameter [1]. Despite the steady increase in prevalence observed in the last few decades, the mortality from thyroid carcinoma is gradually decreasing. Survival data at 30 years after diagnosis indicate that the overwhelming majority of patients with papillary or follicular carcinoma are alive as a result of early diagnosis and multidisciplinary treatment programs.

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References

  1. Chen AY, Jemal A, Ward EM. (2009). Increasing incidence of differentiated thyroid cancer in the United States, 1988–2005. Cancer Aug 15; 115(16): 3801–7.

    Article  Google Scholar 

  2. Duh QY (2012). Thyroid cancer operations for obese patients: the bad news and the good news. Arch Surg 147(9): 811–2. doi: 10.1001/archsurg.2012.911

    Article  PubMed  Google Scholar 

  3. Suarez H.G. (1998). Genetic alterations in human epithelial tumors. Clin Endocrinol, May 48(5): 531–546.

    Article  CAS  Google Scholar 

  4. Lupi C, Giannini R, Ugolini C et al. (2007). Association of BRAF V600 E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab 92(11): 4085–90)

    Article  PubMed  CAS  Google Scholar 

  5. Cradic KW, Milosevic D, Rosenberg AM et al (2009). Mutant BRAF(T 1799A) can be detected in the blood of papillary thyroid carcinoma patients and correlates with disease status. J Clin Endocrinol Metab; 94(12): 5001–9.

    Article  PubMed  CAS  Google Scholar 

  6. Schneider AB., Recant W., Pinsky SM (1986). Radiation-induced thyroid carcinoma. Clinical course and results of therapy in 296 patients. Ann. Intern. Med; 105(3), 405–412

    Article  PubMed  CAS  Google Scholar 

  7. Franceschi S., Boyle P., Maisonneuve P et al (1993). The epidemiology of thyroid carcinoma. Critical Review in Oncogenesis 4(1): 25–52

    CAS  Google Scholar 

  8. Ron E, Lunenfeld B, Menczer J et al (1987). Cancer incidence in a cohort of infertile women. Am J Epidemiol May;125(5): 780–790

    CAS  Google Scholar 

  9. Cooper DS, Doherty GM, Haugen BR et al (2009). Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid; 19(11): 1167–214.

    Article  PubMed  Google Scholar 

  10. Baudin E, Travagli JP, Ropers J et al (1998). Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 83(3): 553–9

    Article  PubMed  CAS  Google Scholar 

  11. Dralle H, Machens A (2012). Surgical management of the lateral neck compartment for metastatic thyroid cancer. Curr Opin Oncol Oct 17

    Google Scholar 

  12. Yu WB, Tao SY, Zhang NS (2012). Is Level V Dissection Necessary for Low-risk Patients with Papillary Thyroid Cancer Metastasis in Lateral Neck Levels II, III, and IV. Asian Pac J Cancer Prev; 13(9): 4619–22

    Article  PubMed  Google Scholar 

  13. Amir A, Payne R, Richardson K et al. (2011) Sentinel lymph node biopsy in thyroid cancer: it can work but there are pitfalls. Otolaryngol Head Neck Surg Nov; 145(5): 723–6.

    Article  Google Scholar 

  14. Sawka AM, Thephamongkhol K, Brouwers M, et al (2004). Clinical review 170: A systematic review and metanalysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer. J Clin Endocrinol Metab 89(8): 3668–76

    Article  PubMed  CAS  Google Scholar 

  15. Byrd JK, Yawn RJ, Wilhoit CS et al (2012). Well Differentiated Thyroid Carcinoma: current treatment. Curr Treat Options Oncol 13(1): 47–57

    Article  PubMed  Google Scholar 

  16. Monchik JM, Donatini G, Iannuccilli J et al. (2006). Radiofrequency ablation and percutaneous ethanol injection treatment for recurrent local and distant well-differentiated thyroid carcinoma. Ann Surg 244(2): 296–304.

    Article  PubMed  Google Scholar 

  17. Turtle RM, Tala H, Shah J et al (2010). Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid 20(12): 1341–9.

    Article  Google Scholar 

  18. Sabour S, Manders E, Steward DL (2009). The role of rapid PACU parathyroid hormone in reducing post-thyroidectomy hypocalcemia. Otolaryngol Head Neck Surg 141(6): 727–9

    Article  PubMed  Google Scholar 

  19. Robbins RJ, Wan Q, Grewal RK, et al. (2006). Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 91(2): 498–505.

    Article  PubMed  CAS  Google Scholar 

  20. Ringel MD., Ldenson P W (2004). Controversies in the follow-up and management of well-differentiated thyroid cancer. Endocr Relat Cancer, 11(1): 97–116.

    Article  PubMed  CAS  Google Scholar 

  21. Schlumberger M (1992).Caniodine-131 whole body scan be replaced by thyreoglobulin measurement in the post surgical follow-up of differentiated thyroid carcinoma. J Nucl Med; 33(1): 172–173

    PubMed  CAS  Google Scholar 

  22. Dionigi G, Van Slycke S, Rausei S et al (2012). Parathyroid function after open thyroidectomy: A prospective randomized study for ligasure precise versus harmonic FOCUS. Head Neck. 2012 Jun 19 (doi: 10.1002/head 23005).

    Google Scholar 

  23. Ecker T, Carvalho AL. Choe JH et al (2010). Hemostasis in thyroid surgery: harmonic scalpel versus other techniques—a meta-analysis. Otolaryngol Head Neck Surg; 143(1): 17–25.

    Article  PubMed  Google Scholar 

  24. Chang J. O’Neill C, Suliburk J et al (2011). Sutureless total thyroidectomy: a safe and cost effective alternative. ANZ J Surg Jul–Aug; 81(7–8): 510–4

    Article  Google Scholar 

  25. Lepner U, Vaasna T (2007). Ligasure vessel sealing system versus conventional vessel ligation in thyroidectomy. Scand J Surg;96(1): 31–34.

    PubMed  CAS  Google Scholar 

  26. Manouras A, Markogiannakis H, Koutras AS et al (2008). Thyroid surgery: comparison between the electrothermal bipolar vessel sealing system, harmonic scalpel, and classic suture ligation. The American Journal of Surgery 195(1): 48–52

    Article  Google Scholar 

  27. Shen WT, Baumbusch MA, Kebebew E et al (2005). Use of the electrothermal vessel sealing system versus standard vessel ligation in thyroidectomy. Asian J Surg;28(2): 86–89

    Article  PubMed  CAS  Google Scholar 

  28. Lombardi CP, Raffaelli M, Cicchetti A et al (2008). The use of ‘harmonic scalpel’ versus ‘knot tying’ for conventional ‘open’ thyroidectomy: results of a prospective randomized study. Langenbecks Arch Surg 393(5): 627–631

    Article  PubMed  Google Scholar 

  29. Saint Marc O, Cogliandolo A, Piquard A et al (2007). LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter. A prospective randomized study. Arch Surg 142(2): 150–6

    Article  Google Scholar 

  30. Higgins TS, Gupta R, Ketcham AS et al (2011). Recurrent laryngeal nerve monitoring versus identification alone on post-thyroidectomy true vocal fold palsy: a meta-analysis. Laryngoscope; 121(5): 1009–17

    Article  PubMed  Google Scholar 

  31. Samraj K, Gurusamy KS (2007). Wound drains following thyroid surgery. Cochrane Database Syst Rev 17(4): CD006099

    Google Scholar 

  32. Kang S W, Park JH, Jeong JS et al (2011). Prospects of robotic thyroidectomy using a gasless, transaxillary approach for the management of thyroid carcinoma. Surg Laparosc Endosc Percutan Tech 21(4): 223–229

    Article  PubMed  Google Scholar 

  33. Miccoli P, Berti P, Conte M et al (1999). Minimally invasive surgery for thyroid small nodules: Preliminary report. J Endocrinol Invest. 22(11): 849–51

    PubMed  CAS  Google Scholar 

  34. Bellantone R, Lombardi CP, Raffaelli M, et al (1999). Minimally invasive, totally gasless video-assisted thyroid lobectomy. Am J Surg 177(4): 342–3

    Article  PubMed  CAS  Google Scholar 

  35. Miccoli P, Berti P, Bendinelli C et al (2000). Minimally invasive video-assisted surgery of the thyroid: a preliminary report. Langenbecks Arch Surg; 385(4): 261–4

    Article  PubMed  CAS  Google Scholar 

  36. Mourad M, Saab N, Malaise J et al (2001). Minimally invasive video-assisted approach for partial and total thyroidectomy: initial experience. Surg Endosc 200115(10): 1108–11

    Article  PubMed  CAS  Google Scholar 

  37. Bellantone R, Lombardi CP, Raffaelli M et al (2002). Video-assisted thyroidectomy. J Am Coll Surg 194(5): 610–4

    Article  PubMed  Google Scholar 

  38. Miccoli P, Berti P, Raffaelli M et al (2001). Minimally invasive video-assisted thyroidectomy. Am J Surg 181(6): 567–70

    Article  PubMed  CAS  Google Scholar 

  39. Bellantone R, Lombardi CP, Raffaelli M et al (2003). Video-assisted thyroidectomy for papillary thyroid carcinoma Surg Endosc 17(10): 1604–8

    Article  PubMed  CAS  Google Scholar 

  40. Miccoli P, Elisei R, Materazzi G et al (2002). Minimally invasive video-assisted thyroidectomy for papillary carcinoma: a prospective study of its completeness. Surgery; 132(6): 1070–4

    Article  PubMed  Google Scholar 

  41. Lai SY, Walvekar RR, Ferris RL (2008). Minimally invasive videoassisted thyroidectomy: expanded indications and oncologic completeness. Head Neck 30(11): 1403–7

    Article  PubMed  Google Scholar 

  42. Kim AT, Liu JC, Ganly I et al (2011). Minimally invasive video-assisted thyroidectomy 2.0: expanded indications in a tertiary care cancer center. Head Neck 33(11): 1557–60 doi: 10.1002/hed 21633

    Article  PubMed  Google Scholar 

  43. Bellantone R, Lombardi CP, Boscherini M et al (1998). Prognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients. J Surg Oncol 68(4): 237–241

    Article  PubMed  CAS  Google Scholar 

  44. Kuppersmith RB, Holsinger FC (2011). Robotic thyroid surgery: an initial experience with North American patients. Laryngoscope 121(3): 521–6.

    Article  PubMed  Google Scholar 

  45. Tae K, Ji YB, Cho SH et al (2012). Early surgical outcomes of robotic thyroidectomy by a gasless unilateral axillo-breast or axillary approach for papillary thyroid carcinoma: 2 years’ experience. Head Neck, 34(5): 617–25

    Article  PubMed  Google Scholar 

  46. Terris DJ, Singer MC, Seybt MW (2011). Robotic facelift thyroidectomy: patient selection and technical considerations. Surg Laparosc Endosc Percutan Tech 21(4): 237–42.

    Article  PubMed  Google Scholar 

  47. Wilhelm T, Metzig A (2011). Endoscopic minimally invasive thyroidectomy (eMIT): a prospective proof-of-concept study in humans. World J Surg 35(3): 543–51

    Article  PubMed  Google Scholar 

  48. Shantz A, Castelman B (1973). Parathyroid carcinoma. A study of 70 cases. Cancer. 31: 600–605.

    Article  Google Scholar 

  49. Shane E (2001). Parathyroid carcinoma. J Clin Endocrinol Metab 86: 485–493.

    Article  PubMed  CAS  Google Scholar 

  50. Clark-Duh-Kebebew (2005). Text Book of Endocrine Surgery 549–554 ISBN 0721601391

    Google Scholar 

  51. Koea JB, Shaw JH (1999). Parathyroid cancer: biology and management. Surg Oncol. 8: 155–165.

    Article  PubMed  CAS  Google Scholar 

  52. Obara T, Fujimoto Y (1991). Diagnosis and treatment of patients with parathyroid carcinoma:an update and review. World J Surg 15: 738–744.

    Article  PubMed  CAS  Google Scholar 

  53. Rosato L (2000) La patologia chirurgica della tiroide e delle paratiroidi 266–269. Grafica San-thiatese Editrice ISBN 8887374511

    Google Scholar 

  54. Shen W, Düren M. Morita E, et al (1996). Reoperation for persistent or recurrent hyperparathyroidism. Arch Surg 131: 861–869

    Article  PubMed  CAS  Google Scholar 

  55. Gary L. Clayman (2004). Parathyroid Carcinoma: Evaluation and Interdisciplinary Management. Cancer 5: 900–905

    Google Scholar 

  56. Vetto JT, Brennan MF, Woodruf J, et al (1993). Parathyroid Carcinoma: diagnosis and clinical history. Surgery 114(5): 882–92

    PubMed  CAS  Google Scholar 

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Correspondence to Micaela Piccoli .

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Piccoli, M., Nigro, C., Mullineris, B., Panconesi, R., Melotti, G. (2013). Well-Differentiated Carcinomas of the Thyroid Gland and Neoplasms of the Parathyroid Glands. In: Valeri, A., Bergamini, C., Agresta, F., Martellucci, J. (eds) What’s New in Surgical Oncology. Springer, Milano. https://doi.org/10.1007/978-88-470-5310-6_13

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  • DOI: https://doi.org/10.1007/978-88-470-5310-6_13

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5309-0

  • Online ISBN: 978-88-470-5310-6

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