Abstract
Albumin is a small highly symmetric, slightly heterogeneous protein weighing 67,000 daltons with a high cysteine content, composed of a single chain of 584 amino acids with a quaternary helix-like structure. The center of the molecule is made up of hydrophobic radicals, which are binding sites for many ligands. The outer part of the molecule is composed of hydrophilic radicals. Albumin is a relatively small protein in terms of space, but its size is sufficient to prevent it from crossing the capillary membrane [1].
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References
Peters Jr (1985) The serum albumin. Adv Protein Chem 37: 161–245
Sgouris JT, Rene A eds (1976) Proceedings of the workshop on albumin, 1975. National Heart and Lung Institute, US Dept of Heath, Education, and Welfare Publication NIH, Bethesda, Maryland, pp 876–925
Tullis JL (1977) Albumin. Background and use. JAMA 237: 355–360
Watkins S, Madison J, Galliano M et al (1994) Analbuminemia: three cases resulting from different point mutations in the albumin gene. Proc Natl Acad Sci U S A 91: 9417–9421
Falkenberg C, Bjork L, Akerstrom B (1992) Localization of the binding site for streptococcal proteins G on human serum albumin. Identification of a 5.5-kilodalton protein G binding albumin fragment. Biochemistry 31: 14551–14557
Kistler P, Nitschmenn HS (1962) Large-scale production of human plasma fractions. Vox Sang 7: 414–424
Burnouf T, Huart JJ (1994) Human albumin: toxicological and viral safety. Arch Public Health 52: 331–345
Laxenaere MC, Charpentier C, Feldman L (1994) Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors mechanisms. A French multicenter prospective study. Ann Fr Anesth Reanim 13: 301–310
Goldwasser P, Feldman J (1997) Association of serum albumin and mortality risk. J Clin Epidemiol 50: 693–703
Grootendorst AF, vanWilgenburg MG, de Laat PH et al (1988) Albumin abuse in intensive care medicine. Intensive Care Med 14: 554–557
James WPT, Hay AM (1988) Albumin metabolism: effect of albumin supplementation during parenteral nutrition on hospital morbidity. Crit Care Med 16: 1177–182
Erstad BL, Gales B, Rappaport WD (1991) The use of albumin in clinical practice. Arch Intern Med 151: 901–911
Swisher SN (ed) (1980) Report of Panel 6 on Safety and Efficacy of Blood and Blood Derivatives. Bureau of Biologies, Food and Drug Administration. The Federal Register
Grundmann R, Heistermann S (1985) Postoperative albumin infusion therapy based on colloid osmotic pressure. Arch Surg 120: 911–915
Foley EF, Borlase BC, Dzik WH et al (1990) Albumin supplementation in the critically ill. Arch Surg 125: 739–742
Stockwell MA, Soni N, Riley B (1992) Colloid solutions in the critically ill: a randomised comparison of albumin and polygeline. 1. Outcome and duration of stay in the intensive care unit. Anaesthesia 47: 3–6
Stockwell MA, Scott A, Day A et al (1992) Colloid solutions in the critically ill. A randomized comparison of albumin and polygeline. 2. Serum albumin concentration and incidences of pulmonary oedema and acute renal failure. Anaesthesia 47: 7–9
Cochrane Injuries Group Albumin Reviewers (1998) Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ 317: 235–239
Monafo WW (1996) Initial management of burns. N Engl J Med 335: 1581–1586
Warden GD (1996) Fluid resuscitation and early management. Total Burn Care 53–60
Schlagintweit S, Snelling CGT, German E et al (1990) Major burns managed without blood or blood products. J Burn Care Rehabil 11: 214
Gore DC, Dalton JM, Gehr TW (1996) Colloid infusions reduce glomerular filtration in resuscitated burn victims. J Trauma 40: 356–360
Vermeulen LC, Ratko TA, Erstad BL et al (1995) A paradigm for consensus. The university hospital consortium guidelines for the use of albumin, nonprotein colloid and crystalloid solutions. Arch Intern Med 155: 373–379
Yim JM, Vermeulen LV, Erstad BI et al (1995) Albumin and non protein colloid solution use in US academic health centers. Arch Intern Med 155: 2450–2455
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Mercuriali, F., Inghilleri, G. (2001). Albumin in Critical Care — Use, Abuse, or Misuse. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2903-3_84
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DOI: https://doi.org/10.1007/978-88-470-2903-3_84
Publisher Name: Springer, Milano
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