Abstract
The acronym TCI, standing for Target Controlled Infusion, refers to a system by which a drug is given intravenously with a pump controlled by a computer; a TCI system aims to get a target plasma concentration chosen by the user [1]. The importance of getting a steady plasma concentration of a drug lies in the link between that concentration and the concentration near the effector, in the assumption that the intensity of the pharmacological effect is proportional to the latter. Since the 1980s, TCI has been largely employed for controlling intravenous infusion of anaesthetics, analgesics, and sedatives since it is particularly suitable to quickly achieve and then maintain satisfactory degrees of anaesthesia, analgesia, and sedation. However, in last years, the use of this technique has been extended to many other drugs, such as antiarrhythmics, antineoplastics, and antibiotics [2–4], all sharing the common property that their pharmacokinetics can be described by a multicompartment model.
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Cavaliere, F., Pennisi, M.A., Proietti, R. (2001). Target-Controlled Infusion: Definition, Methods, and Limits. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2903-3_39
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DOI: https://doi.org/10.1007/978-88-470-2903-3_39
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0136-7
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