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Abstract

Opium (from the Greek word for juice — opion) comes from the seeds of the poppy Papaver somniferum. Evidence of early civilisations cultivating poppy seeds can be found from around 4000 BC and by 2000 BC knowledge of opium was widespread throughout Europe, the Middle East and North Africa, where it was considered a cure for all ailments. Opium was considered important in Greco-Roman pharmacy, and was used to alleviate pain as well as insomnia, coughs, bowel problems and a variety of other conditions. In Europe the use of opium declined with the collapse of the Roman Empire, but re-appeared with the return of the crusaders in the 12th and 13th centuries. By the sixteenth century opium had an established role as a medicine in Europe, and became increasingly popular in the 18th century.

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References

  1. Pert CB, Snyder SH (1973) Properties of opiate receptor binding in rat brain. Proc Natl Acad Sci USA 70: 2243–2247

    Article  PubMed  CAS  Google Scholar 

  2. Simon EJ, Hiller JM, Edelman I (1973) Stereospecific binding of the potent narcotic analgesic [3H]etorphine to rat brain homogenates. Proc Natl Acad Sci USA 70: 1947–1949

    Article  PubMed  CAS  Google Scholar 

  3. Terenius L (1973) Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of the guinea-pig ileum. Acta Pharmacol Toxicol 32: 317–320

    Article  CAS  Google Scholar 

  4. Hughes J (1975) Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res 88: 295–306

    Article  PubMed  CAS  Google Scholar 

  5. Hughes J, Smith TW, Fothergill LA et al (1975) Identification of two related peptides from the brain with potent opiate agonist activity. Nature 258: 577–579

    Article  PubMed  CAS  Google Scholar 

  6. Bradbury AF, Smythe DG, Snell CR (1976) C fragment of lipotropin has a high affinity for brain opiate receptors. Nature 260: 793–795

    Article  CAS  Google Scholar 

  7. Goldstein A, Tachibana S, Lowney LI et al (1979) Dynorphin-(l-13), an extraordinarily potent opioid peptide. Proc Nat Acad Sci USA 76: 6666–6670

    Article  PubMed  CAS  Google Scholar 

  8. Martin WR, Eades CG, Thomson JA et al (1976) The effects of morphine and nalorphine like drugs in the non-dependent and morphine dependent chronic spinal dog. J Pharmacol Exp Therap 197: 517–532

    CAS  Google Scholar 

  9. Manallack DT, Beart PM, Gundlach AL (1986) Psychotomimetric G-opiates and PCP. Tr Pharmacol Sci 7: 448–451

    Article  CAS  Google Scholar 

  10. Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW (1977) Endogenous opioid peptides; multiple agonists and receptors. Nature 267: 495–499

    Article  PubMed  CAS  Google Scholar 

  11. Zadina JE, Hackler L, Ge LJ, Kastin AJ (1997) A potent and selective endogenous agonist for the jn-opioid receptor. Nature 386: 499–502

    Article  PubMed  CAS  Google Scholar 

  12. Hacker L, Zadina JE, Ge LJ, Kastin AJ (1997) Isolation of relatively large amounts of endo-morphin-1 and endomorphin-2 from human brain cortex. Peptides 18: 1635–1639

    Article  Google Scholar 

  13. Stone LS, Fairbanks CA, Laughlin TM et al (1997) Spinal analgesic actions of the new endogenous opioid peptides of endomorphin-1 and endomorphin-2. Neuroreport 8: 3131–3135

    Article  PubMed  CAS  Google Scholar 

  14. Goldberg IE, Rossi GC, Letch worth SR et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther 286: 1007–1013

    PubMed  CAS  Google Scholar 

  15. Champion HC, Zadina JE, Kastin AJ, Kadowitz PJ (1997) The endogenous |Li-opioid receptor agonists, endomorphin-1 and 2 have vasodilator activity in the hindquarters vascular bed of the rat. Life Sci 61:PL409–415

    Google Scholar 

  16. Czapla MA, Champion HC, Zadina JE et al (1998) Endomorphin-1 and 2, endogenous |Li-opi-oid receptor agonists, decrease systemic arterial pressure in the rat. Life Sci 62:PL175–179

    Google Scholar 

  17. Yang YR, Chiu TH, Chen CL (1999) Structure activity relationships of naturally occurring and synthetic opioid tetrapeptides acting on locus ceruleus neurons. Eur J Pharmacol 372: 229–239

    Article  PubMed  CAS  Google Scholar 

  18. Corbett A, McKnight AT, Henderson G (1999) Opioid receptors. In: Tocris Cookson Ltd. sponsored receptor and ion channel nomenclature supplement (Elsiver Trends Journals )

    Google Scholar 

  19. Paul D, Standifer KM, Inturrisi CE, Pasternak GW (1989) Pharmacological characterization of morphine-6-beta-glucuronide, a very potent morphine metabolite. J Pharmacol Exp Therap 251: 477–483

    CAS  Google Scholar 

  20. Brown GP, Yang K, Ouefelli O et al (1997) [3H]morphine-6-p-glucuronide binding in brain membranes and a MOR-1 transfected cell line. J Pharmacol Exp Therap 282: 1291–1297

    CAS  Google Scholar 

  21. Dhawan BN, Celsselin F, Raghubir R et al (1996) International Union of Pharmacology: 12. Classification of opioid receptors. Pharmacol Rev 48: 567–592

    PubMed  CAS  Google Scholar 

  22. Kieffer B, Befort K, Gaveriaux-Ruff C, Hirth CG (1992) The delta-opioid receptor: isolation of cDNA by expression cloning and pharmacological characterization. Proc Nat Acad Sci USA 89: 12048–12052

    Article  PubMed  CAS  Google Scholar 

  23. Evans CJ, Keith DE, Morrison H et al (1992) Cloning of a delta-opioid receptor by functional expression. Science 258: 1952–1955

    Article  PubMed  CAS  Google Scholar 

  24. Yasuda K, Raynor K, Kong H et al (1993) Cloning and functional comparison of kappa-opi-oid and delta-opioid receptors from mouse-brain. Proc Natl Acad Sei USA 90: 6736–6740

    Article  CAS  Google Scholar 

  25. Thompson RC, Mansour A, Akil H, Watson SJ (1993) Cloning and pharmacological characterization of a rat |H-opioid receptor. Neuron 11: 903–913

    Article  PubMed  CAS  Google Scholar 

  26. Birnbaumer L, Yatani A, Vandongen AMJ et al (1990) G-protein coupling of receptors to ionic channels and other effector systems. Br J CI Pharmacol 30: S13 - S22

    Article  Google Scholar 

  27. Law PY, Loh HH (1999) Regulation of opioid receptor activities. J Pharmacol Exp Therap 289: 607–624

    CAS  Google Scholar 

  28. Pasternak GW, Wood PJ (1986) Multiple mu opiate receptors. Life Sei 38: 1889–1898

    Article  CAS  Google Scholar 

  29. Cruciani RA, Dvorkin B, Klinger HP, Makman MH (1994) Presence in neuroblastoma cells of a mu(3) receptor with selectivity for opiate alkaloids but without affinity for opioid peptides. Brain Res 667: 229–237

    Article  PubMed  CAS  Google Scholar 

  30. Traynor JR, Elliott J (1993) Delta opioid receptor subtypes and cross-talk with mu-opioid receptors. Tr Pharmacol Sei 14: 84–86

    Article  CAS  Google Scholar 

  31. Sofuoglu M, Portoghese PS, Takemori AE (1991) Differential antagonism of delta-opioid agonists by naltrindole and its benzofuran analogue ( NTB) in mice - evidence for delta-opioid receptor subtypes. J Pharmacol Exp Therap 257: 676–680

    Google Scholar 

  32. Pasternak GW (1993) Pharmacological mechanisms of opioid analgesics. Clin Neuropharma-col 16: 1–18

    Article  CAS  Google Scholar 

  33. Cheng J, Standifer KM, Tublin PR et al (1995) Demonstration of K3-opioid receptors in the SH-SY5Y human neuroblastoma cell line. J Neurochem 65: 170–175

    Article  PubMed  CAS  Google Scholar 

  34. Foord SM, Marshall FH (1999) RAMPS; accessory proteins for seven transmembrane receptors. Tr Pharmacol Sei 20: 184–187

    Article  CAS  Google Scholar 

  35. Rothman RB, Bykov V, Jacobson AE et al (1992) A study on the effect of [D-Ala- 2Leu5Cys6] Enkephalin on 5CX and 5ncx opioid receptor binding sites in vitro and in vivo. Peptides 92: 691–694

    Article  Google Scholar 

  36. Joarden B, Devi LA (1999) G protein coupled receptor heterodimerization modulates receptor function. Nature 399: 697–700

    Article  Google Scholar 

  37. Onaran HO, Gurdal H (1999) Ligand efficacy and affinity in an interacting 7tm receptor model. Tr Pharmacol Sei 20: 274–278

    Article  CAS  Google Scholar 

  38. Zimprich A, Simon T, Hollt V (1995) rMORl and rMORIB: comparison of both rat ji-opioid receptor variants with respect to second messenger coupling. Analgesia 1: 886–889

    Google Scholar 

  39. Pan YX, Xu J, Bolan E et al (1999) Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. Mol Pharmacol 56: 396–403

    PubMed  CAS  Google Scholar 

  40. Pan ZZ (1998) M-opposing actions of the K-opioid receptor. Tr Pharmacol Sei 19: 94–98

    Article  CAS  Google Scholar 

  41. Wei LN, Hu XL, Bi J, Loh H (2000) Post-transcriptional regulation of mouse kappa-opioid receptor expression. Mol Pharmacol 57: 401–408

    PubMed  CAS  Google Scholar 

  42. Smart D, Hirst RA, Hirota K et al (1997) The effects of recombinant rat |H-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]j and adenylyl cyclase. Br J Pharmacol 120: 1165–1171

    Article  PubMed  CAS  Google Scholar 

  43. Hirst RA, Hirota K, Grandy DK, Lambert DG (1997) Coupling of the cloned rat K-opioid receptor to adenylyl cyclase is dependent on receptor expression. Neurosci Lett 232: 119–122

    Article  PubMed  CAS  Google Scholar 

  44. Hirst RA, Smart D, Devi LA, Lambert DG (1998) Effects of C-terminal truncation of the recombinant 8-opioid receptor on phospholipase C and adenylyl cyclase coupling. J Neurochem 70: 2273–2278

    Article  PubMed  CAS  Google Scholar 

  45. Ingram SL, Williams JT (1994) Opioid inhibition of I-h via adenylyl-cyclase. Neuron 13: 179–186

    Article  PubMed  CAS  Google Scholar 

  46. Seward E, Hammond C, Henderson G (1991) M-opioid-receptor-mediated inhibition of N- type calcium-channel current. Proc R Soc Lond 244: 129–135

    Article  CAS  Google Scholar 

  47. Soldo BL, Moises HC (1998) M-opioid receptor activation inhibits N and P type Ca channel currents in magnocellular neurons of the rat supraoptic nucleus. J Physiol 513: 787–804

    CAS  Google Scholar 

  48. Piros IT, Hales TG, Evans CJ (1996) Functional analysis of cloned receptors in transfected cell lines. Neurochem Res 21: 1277–1285

    Article  PubMed  CAS  Google Scholar 

  49. Christie MJ, North RA, Surprenant A, Williams JT (1987) M-and 8-opioid receptors both belong to a family of neurotransmitter receptors which increase an inwardly rectifying potassium conductance. J Physiol 390: P199

    Google Scholar 

  50. Henry DJ, Grandy DK, Lester HA et al (1995) K-opioid receptors couple to inwardly rectifying potassium channels when coexpressed in Xenopus oocytes. J Pharmacol Exp Therap 47: 551–557

    CAS  Google Scholar 

  51. Han SH, Cho YW, Kim CJ et al (1999) M-opioid agonist induced activation of G protein coupled inwardly rectifying potassium current in rat periaqueductal gray neurons. Neurosci 90: 209–219

    Article  CAS  Google Scholar 

  52. Mansour A, Khachaturian H, Lewis ME et al (1988) Anatomy of CNS opioid receptors. Tr Neurolog Sci 11: 308–314

    Article  CAS  Google Scholar 

  53. George SR, Zastawny RL, Briones-Urbrina R et al (1994) Distinct distribution of mu, delta and kappa opioid receptor mRNA in rat brain. Biochem Biophys Res Comm 205: 1438–1444

    Article  PubMed  CAS  Google Scholar 

  54. Matthes HWD, Maldonado R, Simonin F et al (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the ji-opioid receptor gene. Nature 383: 819–823

    Article  PubMed  CAS  Google Scholar 

  55. Kitchen I, Slowe S, Mattehes HWD, Kieffer B (1997) Quantitative autoradiographic mapping of 8-, and K-opioid receptors in knockout mice lacking the |i-opioid receptor gene. Brain Res 778: 73–88

    Article  PubMed  CAS  Google Scholar 

  56. Simonin F, Valverde O, Smadja C et al (1998) Disruption of the K-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of U50–4088H and attenuates morphine withdrawl. EMBO J 17: 886–897

    Article  PubMed  CAS  Google Scholar 

  57. Zhu YX, King MA, Schuller AGP et al (1999) Retention of delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 24: 243–252

    Article  PubMed  CAS  Google Scholar 

  58. Caló G, Guerrini R, Rizzi A et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol 129: 1261–1283

    Article  PubMed  Google Scholar 

  59. Meunier JC, Mollereau C, Toll L et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL(l) receptor. Nature 377: 532–535

    Article  PubMed  CAS  Google Scholar 

  60. Reinscheid RK, Northacker HP, Bourson A et al (1995) Orphanin-FQ–a neuropeptide that activates an opioid-like G-protein-coupled receptor. Science 270: 792–794

    Article  PubMed  CAS  Google Scholar 

  61. Darland T, Grandy DK (1998) The orphanin FQ system: an emerging target for the management of pain? Br J Anaesth 81: 29–37

    Article  PubMed  CAS  Google Scholar 

  62. Sanders VM (1995) The role of opioid peptides in immune function. In: Tseng LF (ed) The pharmacology of opioid peptides. Harvard Academic Publishers, USA

    Google Scholar 

  63. Webster NR (1998) Opioids and the immune system. Br J Anaesth 81: 835–836

    Article  PubMed  CAS  Google Scholar 

  64. Schaible HG, Grubb BD (1993) Afferent and spinal mechanisms of joint pain. Pain 55: 5–54

    Article  PubMed  CAS  Google Scholar 

  65. Zhou LI, Zhang Q, Stein C, Schafer M (1998) Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia. J Pharmacol Exp Ther 286: 1000–1006

    PubMed  CAS  Google Scholar 

  66. Paakkari P, Feuerstein G (1995) Opioid peptides in cardiovascular and respiratory regulation. In: Tseng LF (ed) The pharmacology of opioid peptides. Harvard Academic Publishers, USA

    Google Scholar 

  67. Burks TF (1995) Opioid peptides in gastrointestinal functions. In: Tseng LF (ed) The pharmacology of opioid peptides. Harvard Academic Publishers, USA

    Google Scholar 

  68. Crighton IM, Martin PH, Hobbs GJ et al (1998) A comparison of the effects of intravenous tramadol, codeine and morphine on gastric emptying in human volunteers. Anaes Analg 87: 445–449

    CAS  Google Scholar 

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© 2001 Springer-Verlag Italia

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Harrison, C., Lambert, D.G. (2001). Opioid Pharmacology. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2903-3_37

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  • DOI: https://doi.org/10.1007/978-88-470-2903-3_37

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0136-7

  • Online ISBN: 978-88-470-2903-3

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