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Advances in Clinical Pharmacology of the Muscle Relaxants

  • Conference paper
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Abstract

Atracurium and vecuronium marked a first revolution in the daily practice of anesthesia in the mid 1980s, paving the way for two distinct approaches to research and practice; the first was slightly more innovative; it was guided by the Wellcome Foundation, later Glaxo Wellcome, which explored the class of benzylisochinolines compounds, characterized by spontaneous degradation via Hoffman reaction (atracurium first and cisatracurium lately) or degradation by plasma enzymes, like pseudocholinesterase, with mivacurium an outstanding example of this class.

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Authors
  1. C. Melloni
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Editors and Affiliations

  1. Dept. of Clinical Sciences, Section of Anaesthesia, Intensive Care and Pain Clinic, Trieste University Medical School, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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© 2001 Springer-Verlag Italia

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Melloni, C. (2001). Advances in Clinical Pharmacology of the Muscle Relaxants. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2903-3_34

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  • DOI: https://doi.org/10.1007/978-88-470-2903-3_34

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0136-7

  • Online ISBN: 978-88-470-2903-3

  • eBook Packages: Springer Book Archive

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