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L’assessment neuropsicologico nella schizofrenia

  • A. GalluzzoEmail author
  • A. Bergamini
  • N. Zorzan

Riassunto

I deficit cognitivi costituiscono una caratteristica centrale della schizofrenia (Lesh et al., 2011) nonché un indice predittivo negativo di disabilità e di outcome funzionale (Green, 1998; Weinberger e Gallhofer, 1997). I deficit cognitivi inoltre risultano essere correlati alla disorganizzazione e ai sintomi negativi (Cohen et al., 1999; Kerns e Berembaum, 2002). I domini cognitivi maggiormente compromessi nella schizofrenia sono: l’attenzione, la velocità di processazione delle informazioni, le funzioni esecutive, in particolare la working memory, la fluenza verbale, la memoria e l’apprendimento verbale (vedi Lesh et al., 2011 per una revisione recente dell’argomento). Le aree cerebrali più coinvolte nei deficit cognitivi sono la corteccia cerebrale frontale e temporale. Esistono molti limiti nella valutazione corretta dei diversi deficit cognitivi in quanto le batterie testali attualmente utilizzate se da un lato sono in grado di indagare più processi cognitivi (Cho et al., 2005), dall’altro richiedono spesso molto tempo per essere somministrate e di conseguenza risultano di difficile applicazione nella pratica clinica e poco adatte a valutazioni ripetute.

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Bibliografia

  1. Amminger GP, Edwards J, Brewer WJ et al (2002) Duration of untreated psychosis and cognitive deterioration in first-episode schizophrenia. Schizophr Res 54:223–230PubMedCrossRefGoogle Scholar
  2. August SM, Kiwanuka JN, McMahon RP, Gold JM (2012) The MATRICS Consensus Cognitive Battery (MCCB): clinical and cognitive correlates. Schizophr Res 134:76–82PubMedCrossRefGoogle Scholar
  3. Basso MR, Nasrallah HA, Olson SC, Bornstein RA (1997) Cognitive deficits distinguish patients with adolescent-and adult-onset schizophrenia Neuropsychiatry Neuropsychol Behav Neurol 10:107–112Google Scholar
  4. Benton A, Hamsher K (1978) Multilingual Aphasia Examination. AJA Associates, Iowa CityGoogle Scholar
  5. Berg EA (1948) A simple objective technique for measuring flexibility in thinking. J Gen Psychol 39:15–22PubMedCrossRefGoogle Scholar
  6. Cho RY, Ford JM, Krystal JH et al (2005) Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia. Schizophr Bull 31:865–869PubMedCrossRefGoogle Scholar
  7. Christodoulou T, Messinis L, Papathanasopoulos P, Frangou S (2012) Dissociable and common deficits in inhibitory control in schizophrenia and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 262:125–130PubMedCrossRefGoogle Scholar
  8. Cirillo MA, Seidman LJ (2003) Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol Rev 13:43–77PubMedCrossRefGoogle Scholar
  9. Clare L, McKenna PJ, Mortimer AL, Baddeley AD (1993) Memory in schizophrenia: what is impaired and what is preserved? Neuropsychologia 31:1225–1241PubMedCrossRefGoogle Scholar
  10. Cohen JD, Barch DM, Carter C, Servan-Schreiber D (1999) Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. J Abnorm Psychol 108:120–133PubMedCrossRefGoogle Scholar
  11. Delis DC, Kramer JH, Kaplan E, Ober BA (1987) California verbal learning test manual. The Psychological Corporation, San Antonio, TexasGoogle Scholar
  12. Gold JM, Goldberg RW, McNary SW et al (2002) Cognitive correlates of job tenure among patients with severe mental illness. Am J Psychiatry 159:1395–1402PubMedCrossRefGoogle Scholar
  13. Green MF (1998) Schizophrenia from a neurocognitive perspective: Probing the impenetrable darkness. Allyn and Bacon, BostonGoogle Scholar
  14. Green MF, Nuechterlein KH (2004) The MATRICS initiative: developing a consensus cognitive battery for clinical trials. Schizophr Res 72:1–3PubMedCrossRefGoogle Scholar
  15. Green MF, Nuechterlein KH, Gold JM et al (2004) Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56:301–307PubMedCrossRefGoogle Scholar
  16. Hawkins KA, Sullivan T, Choi EJ (1997) Memory deficits in schizophrenia: inadequate assimilation or true amnesia? Findings from the Wechsler Memory Scale-Revised. J Psychiatry Neurosci 22:169–179PubMedGoogle Scholar
  17. Holmén A, Juuhl-Langseth M, Thormodsen R et al (2012) Executive function tests in early-onset psychosis: which one to choose? Scand J Psychol 53:200–205PubMedCrossRefGoogle Scholar
  18. Keefe RS, Bilder RM, Harvey PD et al (2006) Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology 31:2033–2046PubMedCrossRefGoogle Scholar
  19. Keefe RS, Goldberg TE, Harvey PD et al (2004) The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res 68:283–297PubMedCrossRefGoogle Scholar
  20. Keefe RS, Poe M, Walker TM et al (2006) The Schizophrenia Cognition Rating Scale: an interview-based assessment and its relationship to cognition, real-world functioning, and functional capacity. Am J Psychiatry 163:426–432PubMedCrossRefGoogle Scholar
  21. Keefe RS, Poe M, Walker TM, Harvey PD (2006) The relationship of the Brief Assessment of Cognition in Schizophrenia (BACS) to functional capacity and real-world functional outcome. J Clin Exp Neuropsychol 28:260–269PubMedCrossRefGoogle Scholar
  22. Kern RS, Green MF, Nuechterlein KH, Deng BH (2004) NIMH-MATRICS survey on assessment of neurocognition in schizophrenia. Schizophr Res 72:11–19PubMedCrossRefGoogle Scholar
  23. Kern RS, Nuechterlein KH, Green MF et al (2008) The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization. Am J Psychiatry 165:214–220PubMedCrossRefGoogle Scholar
  24. Kerns JG, Berenbaum H (2002) Cognitive impairments associated with formal thought disorder in people with schizophrenia. J Abnorm Psychol 111:211–224PubMedCrossRefGoogle Scholar
  25. Lencz T, Smith CW, McLaughlin D et al (2006) Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatry 59(9):863–871PubMedCrossRefGoogle Scholar
  26. Lesh TA, Niendam TA, Minzenberg M, Carter CS (2011) Cognitive control deficits in schizophrenia: mechanisms and meaning. Neuropsychopharmacology 36:316–338PubMedCrossRefGoogle Scholar
  27. Marder SR, Fenton W (2004) Measurement and Treatment Research to Improve Cognition in Schizophrenia: NIMH MATRICS initiative to support the development of agents for improving cognition in schizophrenia. Schizophr Res 72:5–9PubMedCrossRefGoogle Scholar
  28. Martin A, Wiggs CL, Ungerleider LG, Haxby JV (1996) Neural correlates of category specific knowledge. Nature 379:649–652PubMedCrossRefGoogle Scholar
  29. Mortimer AM, Joyce E, Balasubramaniam K et al (2007) Treatment with amisulpiride and olanzapine improve neuropsychological function in schizophrenia. Hum Psychopharmacol 22:445–454PubMedCrossRefGoogle Scholar
  30. Nieuwenstein MR, Aleman A, de Haan H (2001) Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. Wisconsin Card Sorting Test. Continuous PerformanceTest. J Psychiatr Res 35:119–125PubMedCrossRefGoogle Scholar
  31. Nuechterlein KH, Green MF, Kern RS et al (2008) The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry 165:203–213PubMedCrossRefGoogle Scholar
  32. Ojeda N, Peña J, Sánchez P et al (2008) Processing speed mediates the relationship between verbal memory, verbal fluency, and functional outcome in chronic schizophrenia. Schizophr Res 101:225–233PubMedCrossRefGoogle Scholar
  33. Poletti S, Anselmetti S, Riccaboni R et al (2012) Self-awareness of cognitive functioning in schizophrenia: patients and their relatives. Article in pressGoogle Scholar
  34. Polgár P, Réthelyi JM, Bálint S et al (2010) Executive function in deficit schizophrenia: what do the dimensions of the Wisconsin Card Sorting Test tell us? Schizophr Res 122:85–93PubMedCrossRefGoogle Scholar
  35. Rannikko I, Paavola L, Haapea M et al (2012) Verbal learning and memory and their associations with brain morphology and illness course in schizophrenia spectrum psychoses. J Clin Exp Neuropsychol 34:698–713PubMedCrossRefGoogle Scholar
  36. Reitan RM (1958) Validity ofthe Trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276Google Scholar
  37. Rey A (1958). L’examen clinique en psychologie (The psychological examination). Presses Universitaires de France, ParisGoogle Scholar
  38. Rosvold HE, Mirsky AF, Sarason I et al (1956) A Continuous Performance Test of brain damage. J Consult Psychol 20:343–350PubMedCrossRefGoogle Scholar
  39. Sass KJ, Sass A, Westerveld M et al (1992) Specificity in the correlation of verbal memory and hippocampal neuron loss: dissociation of memory, language, and verbal intellectual ability. J Clin Exp Neuropsychol 14:662–672PubMedCrossRefGoogle Scholar
  40. Schein JD (1962) Cross-validation of the Continuous Performance Test for brain damage. J Consult Psychol 26:115–118PubMedCrossRefGoogle Scholar
  41. Stone WS, Giuliano AJ, Tsuang MT et al (2011) Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS). Schizophr Res 128:102–110PubMedCrossRefGoogle Scholar
  42. Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643–662CrossRefGoogle Scholar
  43. Trandafir A, Meary A, Schuerhoff F et al (2006) Memory tests in first-degree adult relatives of schizophrenic patients: a meta-analysis. Schizophr Res 81:217–226PubMedCrossRefGoogle Scholar
  44. Twamley EW, Palmer BW, Jeste DV et al (2006) Transient and executive function working memory in schizophrenia. Schizophr Res 87:185–190PubMedCrossRefGoogle Scholar
  45. Wang Q, Chan R, Sun J et al (2007) Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls. Schizophr Res 89:293–298PubMedCrossRefGoogle Scholar
  46. Wechsler D (1955) Manual for the Wechsler Adult Intelligence Scale. The Psychological Corporation, New YorkGoogle Scholar
  47. Wechsler D (1981) WAIS-R Manual. Wechsler Adult Intelligence Scale Revised. The Psychological Corporation, New YorkGoogle Scholar
  48. Wechsler D (1987) Wechsler Memory Scale. Revised Manual. Psychological Corporation, Harcourt Brace Jovanovich, New YorkGoogle Scholar
  49. Wechsler D (2008) Wechsler Adult Intelligence Scale (WAIS-IV), 4 ednGoogle Scholar
  50. Weinberger DR, Gallhofer B (1997) Cognitive function in schizophrenia. Int Clin Psychopharmacol 12(Suppl):S29–S36PubMedCrossRefGoogle Scholar
  51. Woodberry KA, Giuliano AJ, Seidman LJ (2008) Premorbid IQ in schizophrenia: a meta-analytic review. Am J Psychiatry 165:579–587PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  1. 1.Unità Operativa di Psichiatria 22 Dipartimento di Salute MentaleAzienda Ospedaliera Spedali Civili di BresciaItaly

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