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Fluid Management in Obstetric Patients

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Body Fluid Management

Abstract

In pregnancy, hemodynamic and cardiovascular changes occur that prevent blood loss during delivery. In fact, there is an increase in blood volume, during the first trimester [1]. The volume of blood continues to expand rapidly in the second trimester before reaching a plateau in the last trimester. At the same time, the increase in Red Blood Cell (RBC) mass occurs more slowly, leading to a relative anemia and hemodilution [2], with the latter peaking by 30–32 weeks of gestation. Dilutional anemia is therefore common, especially between 28 and 34 weeks gestation, when hemoglobin concentrations are lowest. The accretion in RBC mass results in an 18–25% increase in the first months of pregnancy, followed by a drop after childbirth due to hemorrhage [3–5]. The increase in red cell volume provides for the extra oxygen demands of the mother and fetus. The lower end of the normal range for hemoglobin in pregnancy is 11–12 g/dL. These physiological responses have considerable advantages during pregnancy: improved placental perfusion, decreased risk of thrombosis and an adequate blood supply despite the bleeding that occurs with childbirth [6–8].

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References

  1. Ickx BE (2010) Fluid and blood transfusion management in obstetrics. European Journal of Anaesthesiology 27:1031–5

    Article  PubMed  Google Scholar 

  2. Bernstein IM, Ziegler W, Badger GJ (2001) Plasma volume expansion in early pregnancy. Obstet Gynecol 97:669

    Article  PubMed  CAS  Google Scholar 

  3. Hytten F (1985) Blood volume changes in normal pregnancy. In: Letsky EA (ed) Haematological Disorders in Pregnancy. London, W.B. Saunders, pp 601–612

    Google Scholar 

  4. Harstad TW, Mason RA, Cox SM (1992) Serum erythropoietin quantitation in pregnancy using an enzyme-linked immunoassay. Am J Perinatol 9:233–235

    Article  PubMed  CAS  Google Scholar 

  5. De Leeuw NK, Lowenstein L, Tucker EC et al (1968) Correlation of red cell loss at delivery with changes in red cell mass. Am J Obstet Gynecol 100:1092–1101

    PubMed  Google Scholar 

  6. Cavill I (1995) Iron and erythropoiesis in normal subjects and in pregnancy. J Perinat Med 23:47–50

    Article  PubMed  CAS  Google Scholar 

  7. Koller O (1982) The clinical significante of hemodilution during pregnancy. Obstet Gynecol Surv 37:649–652

    Article  PubMed  CAS  Google Scholar 

  8. Clapp JF III, Little KD, Widness JA (2003) Effect of maternal exercise and fetoplacental growth rate on serum erythropoietin concentrations. Am J Obstet Gynecol 188:1021

    Article  PubMed  CAS  Google Scholar 

  9. Peck TM, Arias F (1979) Hematologic changes associated with pregnancy. Clin Obstet Gynecol 22:785–798

    Article  PubMed  CAS  Google Scholar 

  10. Sejeny SA, Eastham RD, Baker SR (1975) Platelet counts during normal pregnancy. J Clin Pathol 28:812–813

    Article  PubMed  CAS  Google Scholar 

  11. O’Brien JR (1976) Letter: platelet counts in normal pregnancy. J Clin Pathol 29:174

    Article  CAS  Google Scholar 

  12. Rakoczi I, Tallian F, Bagdany S et al (1979) Platelet life-span in normal pregnancy and preeclampsia asdetermined by a non-radioisotope technique. Thromb Res 15:553–556

    Article  PubMed  CAS  Google Scholar 

  13. Burrows RF, Kelton JG (1990) Thrombocytopenia at delivery: a prospective survey of 6715 deliveries. Am J Obstet Gynecol 162: 731–734

    Article  PubMed  CAS  Google Scholar 

  14. Hellgren M (1996) Hemostasis during pregnancy and puerperium. Haemostasis 26(Suppl 4):244–247

    PubMed  CAS  Google Scholar 

  15. Davis GL (2000) Hemostatic changes associated with normal and abnormal pregnancies. Clin Lab Sci 13:223–228

    PubMed  CAS  Google Scholar 

  16. Seitchik J (1967) Total body water and total body density of pregnant women. Obstet Gynecol 29:155

    PubMed  CAS  Google Scholar 

  17. Theunissen IM, Parer JT (1994) Fluid and electrolytes in pregnancy. Clin Obstet Gynecol 37:3

    Article  PubMed  CAS  Google Scholar 

  18. Lindheimer MD, Katz AI (1973) Sodium and diuretics in pregnancy. N Engl J Med 288:891

    Article  PubMed  CAS  Google Scholar 

  19. Lindheimer M, Barron WM (1998) Renal function and volume homeostasis. In: Gleicher N, Buttino L, Elkayam U (eds) Principles and Practice of Medical Therapy in Pregnancy. 3 edn. Stanford, CT, Appleton and Lange, pp 1043–1052

    Google Scholar 

  20. Davison JM, Vallotton MB, Lindheimer MD (1981) Plasma osmolality and urinary concentration and dilution during and after pregnancy: evidence that lateral recumbency inhibits maximal urinary concentrating ability. Br J Obstet Gynaecol 88:472–479

    Article  PubMed  CAS  Google Scholar 

  21. Bader RA, Bader MG & Rose DG (1955) Hemodynamics at rest and during exercise in pregnancy as studied by cardiac catherization. J Clin Invest 34:1524

    Article  PubMed  CAS  Google Scholar 

  22. Clark SL, Cotton DB, Wetal L (1989) Central hemodynamic assessment of normal term pregnancy. Am J Obstet Gynecol 161:1439–1442

    Article  PubMed  CAS  Google Scholar 

  23. Easterling TR, Watts DH, Schmucker BC et al (1987) Measurement of cardiac output during pregnancy: validation of Doppler technique and clinical observations in preeclampsia. Obstet Gynecol 69:845–850

    PubMed  CAS  Google Scholar 

  24. Katz R, Karliner JS, Resnik R (1978) Effects of a natural volume overload state (pregnancy) on left ventricular performance in normal human subjects. Circulation 58:434–441

    Article  PubMed  CAS  Google Scholar 

  25. Atrash HK, Koonin LM, Lawson HW et al (1990) Maternal mortality in the United States, 1979–1986. Obstet Gynecol 76:1055

    PubMed  CAS  Google Scholar 

  26. Kamani AA, McMorland GH, Wadsworth LD (1988) Utilization of red blood cell transfusion in an obstetric setting. Am J Obstet Gynecol 159:1177

    PubMed  CAS  Google Scholar 

  27. Kapholz H (1990) Blood transfusion in contemporary obstetric practice. Obstet Gynecol 75:940

    Google Scholar 

  28. Tsu VD, Langer A, Aldrich T (2004) Postpartum hemorrhage in developing countries: is the public health community using the right tools? Int J Gynaecol Obstet 85(Suppl 1):S42–S51

    Article  PubMed  Google Scholar 

  29. Doumouchtsis SK, Papageorghiou AT, Arulkumaran S (2007) Systematic review of conservative management of postpartum hemorrhage: what to do when medical treatment fails. Obstet Gynecol Surv 62:540–547

    Article  PubMed  Google Scholar 

  30. Chichakli LO, Atrash HK, Mackay AP et al (1999) Pregnancy-related mortality in the United States due to hemorrhage: 1979–1992. Obstet Gynecol 94:721–725

    Article  PubMed  CAS  Google Scholar 

  31. Cohen WR (2006) Hemorrhagic shock in obstetrics. J Perinat Med 34:263–271

    Article  PubMed  Google Scholar 

  32. Chong Y-S, Su L-L, Arulkumaran S (2004) Current strategies for the prevention of postpartum haemorrhage in the third stage of labour. Curr Opin Obstet Gynecol 16:143–150

    Article  PubMed  Google Scholar 

  33. Letsky EA (2001) Disseminated intravascular coagulation. Best Pract Res Clin Obstet Gynaecol 15:623–644

    Article  PubMed  CAS  Google Scholar 

  34. Bick RL (2002) Disseminated intravascular coagulation: a review of etiology, pathophysiology, diagnosis, and management: guidelines for care. Clin Appl Thromb Hemost 8:1–31

    Article  PubMed  CAS  Google Scholar 

  35. Djelmis J, Ivanisevic M, Kurjak A et al (2001) Hemostatic problems before, during and after delivery. J Perinat Med 29:241–246

    Article  PubMed  CAS  Google Scholar 

  36. Kobayashi T, Terao T, Maki M et al (2001) Diagnosis and management of acute obstetrical DIC. Semin Thrombosis Hemostasis 27:161–167

    Article  CAS  Google Scholar 

  37. DeLoughery TG (2005) Critical care clotting catastrophies. Crit Care Clin 21:531–562

    Article  PubMed  Google Scholar 

  38. Pepas LP, Arif-Adib M, Kadir RA (2006) Factor VIIa in puerperal hemorrhage with disseminated intravascular coagulation. Obstet Gynecol 108:757–761

    Article  PubMed  Google Scholar 

  39. Burtelow M, Riley E, Druzin M et al (2007) How we treat: management of life-threatening primary postpartum hemorrhage with a standardized massive transfusion protocol. Transfusion 47:1564–1572

    Article  PubMed  CAS  Google Scholar 

  40. Van der Linden P, Ickx BE (2006) The effects of colloid solutions on hemostasis. Can J Anaesth 53(6 Suppl):S30–S39

    PubMed  Google Scholar 

  41. Finfer S, Bellomo R, Boyce N et al (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350:2247–2256

    Article  PubMed  CAS  Google Scholar 

  42. Boldt J (2007) The balanced concept of fluid resuscitation. Br J Anaesth 99:312–315

    Article  PubMed  CAS  Google Scholar 

  43. Mion G, Rüttimann M (1997) Loading with hypertonic saline solution during pregnancy toxemia. Ann Fr Anesth Reanim 16:1046–1047

    Article  PubMed  CAS  Google Scholar 

  44. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies (2006) Practice guidelines for perioperative blood transfusion and adjuvant therapies. Anesthesiology 105:198–208

    Article  Google Scholar 

  45. Cotton DB, Longmire S, Jones MM et al (1986) Cardiovascular alterations in severe pregnancy-induced hypertension: Effects of intravenous nitroglycerin coupled with blood volume expansion. Am J Obstet Gynecol 154:1053–9

    PubMed  CAS  Google Scholar 

  46. Wasserstrum N (1992) Issues in fluid management during labor: Maternal plasma volume status and volume loading. Clin Obstet Gynecol 35:514–26

    Article  PubMed  CAS  Google Scholar 

  47. Hankins SDV, Wendel GD, Cunningham FG et al (1984) Longitudinal evaluation of hemodynamic changes in eclampsia. Am J Obstet Gynecol 150:506–12

    PubMed  CAS  Google Scholar 

  48. Pearson JF (1992) Fluid balance in severe pre-eclampsia. Br J Hosp Med 48:47–51

    PubMed  CAS  Google Scholar 

  49. Jones MM, Longmire S, Cotton DB et al (1986) Influence of crystalloid versus colloid infusion on peripartum colloid osmotic pressure changes. Obstet Gynecol 68:659–61

    PubMed  CAS  Google Scholar 

  50. Kirshon B, Moise JK Jr, Cotton DB et al (1988): Role of volume expansion in severe pre-eclampsia. Surg Gynecol Obstet 167:367–71

    PubMed  CAS  Google Scholar 

  51. Clark SL, Greenspoon JS, Aldahl D et al (1986) Severe preeclampsia with persistent oliguria: Management of hemodynamic subsets. Am J Obstet Gynecol 154:490–4

    PubMed  CAS  Google Scholar 

  52. Kapholz H (1990) Blood transfusion in contemporary obstetric practice. Obstet Gynecol 75:940–3

    Google Scholar 

  53. Pritchard JA, MacDonald PC, Leveno KJ et al (1985) Hypertensive disorders in pregnancy. In: Pritchard JA, MacDonald PC, Leveno KJ et al (eds) Williams Obstetrics, 17 edn. Connecticut, Appleton-Century-Crofts, p 551

    Google Scholar 

  54. Lindheimer MD, Katz AI (1985) Current concepts: Hypertension in pregnancy. N Engl J Med 313:675

    Article  PubMed  CAS  Google Scholar 

  55. Dyer RA, Piercy JL, Reed AR (2007) The role of the anaesthetist in the management of the pre-eclamptic patient. Curr Opin Anaesthesiol 20:168–174

    Article  PubMed  Google Scholar 

  56. Aya AG, Mangin R, Vialles N et al (2003) Patients with severe preeclampsia experience less hypotension during spinal anesthesia for elective cesarean delivery than healthy parturients: a prospective cohort comparison. Anesth Analg; 97:867–872

    Article  PubMed  Google Scholar 

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Correspondence to Annalaura Di Pumpo .

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Frigo, M.G., Di Pumpo, A., Agrò, F.E. (2013). Fluid Management in Obstetric Patients. In: Agrò, F.E. (eds) Body Fluid Management. Springer, Milano. https://doi.org/10.1007/978-88-470-2661-2_15

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  • DOI: https://doi.org/10.1007/978-88-470-2661-2_15

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2660-5

  • Online ISBN: 978-88-470-2661-2

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