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Cardiovascular and Metabolic Indices

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Book cover Long-Term Oxygen Therapy

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Abstract

Patients on long-term oxygen therapy (LTOT) are commonly plagued with cardiovascular and metabolic problems. Indeed, they are usually ex-smokers and are affected by conditions such as COPD or pulmonary fibrosis carrying an important cardiovascular risk [1]. Furthermore, physical inactivity per se and vitamin D deficiency, both highly prevalent in hypoxemic COPD patients [2], negatively affect glucose metabolism and have a proinflammatory effect [3]. Older age also — the mean age of LTOT patients being 74 years [1] — qualifies as a risk factor for cardiovascular and metabolic conditions. Furthermore, hypoxemia induces hemodynamic and metabolic changes with important clinical effects (see next section). Finally, exacerbations of baseline respiratory conditions impact both the cardiovascular and metabolic status, with important effects on the inherent markers. We will summarize first the cardiovascular and metabolic effects of hypoxemia and try to distinguish them from problems related to the underlying respiratory conditions and related comorbidity. Then we will review the main diagnostic indices and how they fluctuate as a consequence of exacerbations, new comorbidities and pharmacologic interventions. The final section will be devoted to a very practical choice of indices useful for every day clinical practice.

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Author information

Authors and Affiliations

  1. Unit of Geriatric Pharmacoepidemiology, Italian National Research Center on Aging (INRCA), Cosenza, Italy

    Andrea Corsonello

  2. University Campus Bio Medico, Rome, Italy

    Claudio Pedone (Chair of Geriatrics), Simone Scarlata (Chair of Geriatrics) & Raffaele Antonelli Incalzi (Chair of Geriatrics)

Authors
  1. Andrea Corsonello
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  2. Claudio Pedone
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  3. Simone Scarlata
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  4. Raffaele Antonelli Incalzi
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Corresponding author

Correspondence to Raffaele Antonelli Incalzi .

Editor information

Editors and Affiliations

  1. Lung Unit and Department of Internal Medicine ULSS 22 Regione Veneto, Bussolengo Hospital, Verona, Italy

    Roberto Walter Dal Negro

  2. Divisions of Pulmonary and Critical Care, University of Ottawa, The Ottawa Hospital-Civic Campus, Ottawa, ON, Canada

    Richard Hodder

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© 2012 Springer-Verlag Italia

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Corsonello, A., Pedone, C., Scarlata, S., Incalzi, R.A. (2012). Cardiovascular and Metabolic Indices. In: Dal Negro, R.W., Hodder, R. (eds) Long-Term Oxygen Therapy. Springer, Milano. https://doi.org/10.1007/978-88-470-2580-6_3

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  • DOI: https://doi.org/10.1007/978-88-470-2580-6_3

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2579-0

  • Online ISBN: 978-88-470-2580-6

  • eBook Packages: MedicineMedicine (R0)

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