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Hemostasis in Pregnancy and Obstetric Surgery

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Hemocoagulative Problems in the Critically Ill Patient

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Abstract

Normal pregnancy is associated with changes in all aspects of hemostasis, including an increase in concentrations of most clotting factors, decreasing concentrations of some of the natural anticoagulants, and diminishing fibrinolytic activity. These changes help in maintaining placental function during pregnancy and meeting delivery’s hemostatic challenge, but may predispose to thrombosis and placental vascular complications. Pregnancy is considered to be a hypercoagulable state and encompasses all three elements of Virchow’s triad. Coagulation anomalies play an important role in adverse pregnancy outcome. Complications which occur during pregnancy are the cause of morbidity and mortality and necessitate medical intervention aimed at improving the fetal and maternal outcome. Thrombophilias have been investigated in relation to the following obstetric complications: recurrent and nonrecurrent miscarriages in early or late pregnancy, intrauterine death, intrauterine growth retardation, placental abruption, hypertensive disorders of pregnancy, and maternal or neonatal thrombosis.

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References

  1. Brenner B (2004) Haemostatic changes in pregnancy. Thromb Res 114(5–6):409–414

    Article  PubMed  CAS  Google Scholar 

  2. Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW (1984) Haemostasis in normal pregnancy. Thromb Haemost 52(2):176–182

    PubMed  CAS  Google Scholar 

  3. Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID (1998) Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 79(6):1166–1170

    PubMed  CAS  Google Scholar 

  4. Kjellberg U, Andersson NE, Rosen S, Tengborn L, Hellgren M (1999) APC resistance and other haemostatic variables during pregnancy and puerperium. Thromb Haemost 81(4):527–531

    PubMed  CAS  Google Scholar 

  5. Condie RG (1976) A serial study of coagulation factors XII, XI and X in plasma in normal pregnancy and in pregnancy complicated by pre-eclampsia. Br J Obstet Gynaecol 83(8):636–639

    Article  PubMed  CAS  Google Scholar 

  6. Nilsson IM, Kullander S (1967) Coagulation and fibrinolytic studies during pregnancy. Acta Obstet Gynecol Scand 46(3):273–285

    Article  PubMed  CAS  Google Scholar 

  7. Hellgren M, Blomback M (1981) Studies on blood coagulation and fibrinolysis in pregnancy, during delivery and in the puerperium. I. Normal condition. Gynecol Obstet Invest 12(3):141–154

    Article  PubMed  CAS  Google Scholar 

  8. Lefkowitz JB, Clarke SH, Barbour LA (1996) Comparison of protein S functional and antigenic assays in normal pregnancy. Am J Obstet Gynecol 175(3 Pt 1):657–660

    Article  PubMed  CAS  Google Scholar 

  9. Walker MC, Garner PR, Keely EJ, Rock GA, Reis MD (1997) Changes in activated protein C resistance during normal pregnancy. Am J Obstet Gynecol 177(1):162–169

    Article  PubMed  CAS  Google Scholar 

  10. Phillips LL, Rosano L, Skrodelis V (1973) Changes in factor XI (plasma thromboplastin antecedent) levels during pregnancy. Am J Obstet Gynecol 116(8):1114–1116

    PubMed  CAS  Google Scholar 

  11. Boffa MC, Valsecchi L, Fausto A, Gozin D, Vigano’ D’Angelo S, Safa O et al (1998) Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension. Thromb Haemost 79(6):1092–1095

    PubMed  CAS  Google Scholar 

  12. Gonzalez R, Alberca I, Vicente V (1985) Protein C levels in late pregnancy, postpartum and in women on oral contraceptives. Thromb Res 39(5):637–640

    Article  PubMed  CAS  Google Scholar 

  13. Gilabert J, Fernandez JA, Espana F, Aznar J, Estelles A (1988) Physiological coagulation inhibitors (protein S, protein C and antithrombin III) in severe preeclamptic states and in users of oral contraceptives. Thromb Res 49(3):319–329

    Article  PubMed  CAS  Google Scholar 

  14. Aznar J, Gilabert J, Estelles A, Espana F (1986) Fibrinolytic activity and protein C in preeclampsia. Thromb Haemost 55(3):314–317

    PubMed  CAS  Google Scholar 

  15. Faught W, Garner P, Jones G, Ivey B (1995) Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol 172(1 Pt 1):147–150

    Article  PubMed  CAS  Google Scholar 

  16. Hopmeier P, Halbmayer M, Schwarz HP, Heuss F, Fischer M (1987) Protein C and protein S in mild and moderate preeclampsia. Thromb Haemost 58(2):794–795

    PubMed  CAS  Google Scholar 

  17. Lao TT, Yuen PM, Yin JA (1989) Protein S and protein C levels in Chinese women during pregnancy, delivery and the puerperium. Br J Obstet Gynaecol 96(2):167–170

    Article  PubMed  CAS  Google Scholar 

  18. Espana F, Gilabert J, Aznar J, Estelles A, Kobayashi T, Griffin JH (1991) Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia. Am J Obstet Gynecol 164(5 Pt 1):1310–1316

    PubMed  CAS  Google Scholar 

  19. Woodhams BJ, Candotti G, Shaw R, Kernoff PB (1989) Changes in coagulation and fibrinolysis during pregnancy: evidence of activation of coagulation preceding spontaneous abortion. Thromb Res 55(1):99–107

    Article  PubMed  CAS  Google Scholar 

  20. Gatti L, Tenconi PM, Guarneri D, Bertulessi C, Ossola MW, Bosco P et al (1994) Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study. Int J Clin Lab Res 24(4):217–219

    Article  PubMed  CAS  Google Scholar 

  21. Halligan A, Bonnar J, Sheppard B, Darling M, Walshe J (1994) Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre-eclampsia. Br J Obstet Gynaecol 101(6):488–492

    Article  PubMed  CAS  Google Scholar 

  22. Malm J, Laurell M, Dahlback B (1988) Changes in the plasma levels of vitamin K-dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception. Br J Haematol 68(4):437–443

    Article  PubMed  CAS  Google Scholar 

  23. Comp PC, Thurnau GR, Welsh J, Esmon CT (1986) Functional and immunologic protein S levels are decreased during pregnancy. Blood 68(4):881–885

    PubMed  CAS  Google Scholar 

  24. Fernandez JA, Estelles A, Gilabert J, Espana F, Aznar J (1989) Functional and immunologic protein S in normal pregnant women and in full-term newborns. Thromb Haemost 61(3):474–478

    PubMed  CAS  Google Scholar 

  25. Bremme K, Ostlund E, Almqvist I, Heinonen K, Blomback M (1992) Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium. Obstet Gynecol 80(1):132–137

    PubMed  CAS  Google Scholar 

  26. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H et al (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369(6475):64–67

    Article  PubMed  CAS  Google Scholar 

  27. Bokarewa MI, Bremme K, Falk G, Sten-Linder M, Egberg N, Blomback M (1995) Studies on phospholipid antibodies, APC-resistance and associated mutation in the coagulation factor V gene. Thromb Res 78(3):193–200

    Article  PubMed  CAS  Google Scholar 

  28. Haim N, Lanir N, Hoffman R, Haim A, Tsalik M, Brenner B (2001) Acquired activated protein C resistance is common in cancer patients and is associated with venous thromboembolism. Am J Med 110(2):91–96

    Article  PubMed  CAS  Google Scholar 

  29. Cumming AM, Tait RC, Fildes S, Yoong A, Keeney S, Hay CR (1995) Development of resistance to activated protein C during pregnancy. Br J Haematol 90(3):725–727

    Article  PubMed  CAS  Google Scholar 

  30. Castoldi E, Brugge JM, Nicolaes GA, Girelli D, Tans G, Rosing J (2004) Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 103(11):4173–4179

    Article  PubMed  CAS  Google Scholar 

  31. Mathonnet F, de Mazancourt P, Bastenaire B, Morot M, Benattar N, Beufe S et al (1996) Activated protein C sensitivity ratio in pregnant women at delivery. Br J Haematol 92(1):244–246

    Article  PubMed  CAS  Google Scholar 

  32. Clark P, Sattar N, Walker ID, Greer IA (2001) The glasgow outcome, APCR and lipid (GOAL) pregnancy study: significance of pregnancy associated activated protein C resistance. Thromb Haemost 85(1):30–35

    PubMed  CAS  Google Scholar 

  33. Vasse M, Leduc O, Borg JY, Chretien MH, Monconduit M (1994) Resistance to activated protein C: evaluation of three functional assays. Thromb Res 76(1):47–59

    Article  PubMed  CAS  Google Scholar 

  34. Bokarewa MI, Bremme K, Blomback M (1996) Arg506-Gln mutation in factor V and risk of thrombosis during pregnancy. Br J Haematol 92(2):473–478

    Article  PubMed  CAS  Google Scholar 

  35. Eichinger S, Weltermann A, Philipp K, Hafner E, Kaider A, Kittl EM et al (1999) Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden. Thromb Haemost 82(4):1232–1236

    PubMed  CAS  Google Scholar 

  36. Bauer KA, Rosenberg RD (1987) The pathophysiology of the prethrombotic state in humans: insights gained from studies using markers of hemostatic system activation. Blood 70(2):343–350

    PubMed  CAS  Google Scholar 

  37. de Boer K, ten Cate JW, Sturk A, Borm JJ, Treffers PE (1989) Enhanced thrombin generation in normal and hypertensive pregnancy. Am J Obstet Gynecol 160(1):95–100

    PubMed  Google Scholar 

  38. Reinthaller A, Mursch-Edlmayr G, Tatra G (1990) Thrombin-antithrombin III complex levels in normal pregnancy with hypertensive disorders and after delivery. Br J Obstet Gynaecol 97(6):506–510

    Article  PubMed  CAS  Google Scholar 

  39. Cadroy Y, Grandjean H, Pichon J, Desprats R, Berrebi A, Fournie A et al (1993) Evaluation of six markers of haemostatic system in normal pregnancy and pregnancy complicated by hypertension or pre-eclampsia. Br J Obstet Gynaecol 100(5):416–420

    Article  PubMed  CAS  Google Scholar 

  40. Comeglio P, Fedi S, Liotta AA, Cellai AP, Chiarantini E, Prisco D et al (1996) Blood clotting activation during normal pregnancy. Thromb Res 84(3):199–202

    Article  PubMed  CAS  Google Scholar 

  41. Delorme MA, Burrows RF, Ofosu FA, Andrew M (1992) Thrombin regulation in mother and fetus during pregnancy. Semin Thromb Hemost 18(1):81–90

    Article  PubMed  CAS  Google Scholar 

  42. Weenink GH, Treffers PE, Kahle LH, ten Cate JW (1982) Antithrombin III in normal pregnancy. Thromb Res 26(4):281–287

    Article  PubMed  CAS  Google Scholar 

  43. Ramalakshmi BA, Raju LA, Raman L (1995) Antithrombin III levels in pregnancy induced hypertension. Natl Med J India 8(2):61–62

    PubMed  CAS  Google Scholar 

  44. Maruyama I, Bell CE, Majerus PW (1985) Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 101(2):363–371

    Article  PubMed  CAS  Google Scholar 

  45. Esmon CT, Owen WG (1981) Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A 78(4):2249–2252

    Article  PubMed  CAS  Google Scholar 

  46. Esmon CT, Esmon NL, Harris KW (1982) Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem 257(14):7944–7947

    PubMed  CAS  Google Scholar 

  47. Esmon NL, Carroll RC, Esmon CT (1983) Thrombomodulin blocks the ability of thrombin to activate platelets. J Biol Chem 258(20):12238–12242

    PubMed  CAS  Google Scholar 

  48. Hofsteenge J, Taguchi H, Stone SR (1986) Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors. Biochem J 237(1):243–251

    PubMed  CAS  Google Scholar 

  49. Ishii H, Majerus PW (1985) Thrombomodulin is present in human plasma and urine. J Clin Invest 76(6):2178–2181

    Article  PubMed  CAS  Google Scholar 

  50. Boffa MC (1996) Considering cellular thrombomodulin distribution and its modulating factors can facilitate the use of plasma thrombomodulin as a reliable endothelial marker? Haemostasis 26(Suppl 4):233–243

    PubMed  CAS  Google Scholar 

  51. Suzuki K, Nishioka J, Hashimoto S (1983) Protein C inhibitor. Purification from human plasma and characterization. J Biol Chem 258(1):163–168

    PubMed  CAS  Google Scholar 

  52. Heeb MJ, Espana F, Griffin JH (1989) Inhibition and complexation of activated protein C by two major inhibitors in plasma. Blood 73(2):446–454

    PubMed  CAS  Google Scholar 

  53. Marlar RA, Kressin DC, Madden RM (1993) Contribution of plasma proteinase inhibitors to the regulation of activated protein C in plasma. Thromb Haemost 69(1):16–20

    PubMed  CAS  Google Scholar 

  54. Hoogendoorn H, Toh CH, Nesheim ME, Giles AR (1991) Alpha 2-macroglobulin binds and inhibits activated protein C. Blood 78(9):2283–2290

    PubMed  CAS  Google Scholar 

  55. Gruber A, Griffin JH (1992) Direct detection of activated protein C in blood from human subjects. Blood 79(9):2340–2348

    PubMed  CAS  Google Scholar 

  56. Bauer KA, Kass BL, Beeler DL, Rosenberg RD (1984) Detection of protein C activation in humans. J Clin Invest 74(6):2033–2041

    Article  PubMed  CAS  Google Scholar 

  57. Ishii A, Yamada S, Yamada R, Hamada H (1994) t-PA activity in peripheral blood obtained from pregnant women. J Perinat Med 22(2):113–117

    Article  PubMed  CAS  Google Scholar 

  58. Lecander I, Astedt B (1986) Isolation of a new specific plasminogen activator inhibitor from pregnancy plasma. Br J Haematol 62(2):221–228

    Article  PubMed  CAS  Google Scholar 

  59. Wright JG, Cooper P, Astedt B, Lecander I, Wilde JT, Preston FE et al (1988) Fibrinolysis during normal human pregnancy: complex inter-relationships between plasma levels of tissue plasminogen activator and inhibitors and the euglobulin clot lysis time. Br J Haematol 69(2):253–258

    Article  PubMed  CAS  Google Scholar 

  60. Kruithof EK, Tran-Thang C, Gudinchet A, Hauert J, Nicoloso G, Genton C et al (1987) Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood 69(2):460–466

    PubMed  CAS  Google Scholar 

  61. Booth NA, Bennett B (1994) Fibrinolysis and thrombosis. Baillieres Clin Haematol 7(3):559–572

    Article  PubMed  CAS  Google Scholar 

  62. Astedt B, Hagerstrand I, Lecander I (1986) Cellular localisation in placenta of placental type plasminogen activator inhibitor. Thromb Haemost 56(1):63–65

    PubMed  CAS  Google Scholar 

  63. Estelles A, Gilabert J, Espana F, Aznar J, Galbis M (1991) Fibrinolytic parameters in normotensive pregnancy with intrauterine fetal growth retardation and in severe preeclampsia. Am J Obstet Gynecol 165(1):138–142

    PubMed  CAS  Google Scholar 

  64. Craven CM, Chedwick LR, Ward K (2002) Placental basal plate formation is associated with fibrin deposition in decidual veins at sites of trophoblast cell invasion. Am J Obstet Gynecol 186(2):291–296

    Article  PubMed  Google Scholar 

  65. Sheppard BL, Bonnar J (1999) Uteroplacental hemostasis in intrauterine fetal growth retardation. Semin Thromb Hemost 25(5):443–446

    Article  PubMed  CAS  Google Scholar 

  66. Lockwood CJ, Krikun G, Runic R, Schwartz LB, Mesia AF, Schatz F (2000) Progestin-epidermal growth factor regulation of tissue factor expression during decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 85(1):297–301

    Article  PubMed  CAS  Google Scholar 

  67. Lanir N, Aharon A, Brenner B (2003) Haemostatic mechanisms in human placenta. Best Pract Res Clin Haematol 16(2):183–195

    Article  PubMed  CAS  Google Scholar 

  68. Aharon A, Brenner B, Katz T, Miyagi Y, Lanir N (2004) Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis. Thromb Haemost 92(4):776–786

    PubMed  CAS  Google Scholar 

  69. Meziani F, Tesse A, Andriantsitohaina R (2008) Microparticles are vectors of paradoxical information in vascular cells including the endothelium: role in health and diseases. Pharmacol Rep 60(1):75–84

    PubMed  CAS  Google Scholar 

  70. VanWijk MJ, VanBavel E, Sturk A, Nieuwland R (2003) Microparticles in cardiovascular diseases. Cardiovasc Res 59(2):277–287

    Article  PubMed  CAS  Google Scholar 

  71. Combes V, Simon AC, Grau GE, Arnoux D, Camoin L, Sabatier F et al (1999) In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Invest 104(1):93–102

    Article  PubMed  CAS  Google Scholar 

  72. Mallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM et al (2000) Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 101(8):841–843

    PubMed  CAS  Google Scholar 

  73. Bretelle F, Sabatier F, Desprez D, Camoin L, Grunebaum L, Combes V et al (2003) Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction. Thromb Haemost 89(3):486–492

    PubMed  CAS  Google Scholar 

  74. Laude I, Rongieres-Bertrand C, Boyer-Neumann C, Wolf M, Mairovitz V, Hugel B et al (2001) Circulating procoagulant microparticles in women with unexplained pregnancy loss: a new insight. Thromb Haemost 85(1):18–21

    PubMed  CAS  Google Scholar 

  75. Harlow FH, Brown MA, Brighton TA, Smith SL, Trickett AE, Kwan YL et al (2002) Platelet activation in the hypertensive disorders of pregnancy. Am J Obstet Gynecol 187(3):688–695

    Article  PubMed  Google Scholar 

  76. VanWijk MJ, Boer K, Berckmans RJ, Meijers JC, van der Post JA, Sturk A et al (2002) Enhanced coagulation activation in preeclampsia: the role of APC resistance, microparticles and other plasma constituents. Thromb Haemost 88(3):415–420

    PubMed  CAS  Google Scholar 

  77. Knight M, Redman CW, Linton EA, Sargent IL (1998) Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol 105(6):632–640

    Article  PubMed  CAS  Google Scholar 

  78. VanWijk MJ, Nieuwland R, Boer K, van der Post JA, VanBavel E, Sturk A (2002) Microparticle subpopulations are increased in preeclampsia: possible involvement in vascular dysfunction? Am J Obstet Gynecol 187(2):450–456

    Article  PubMed  Google Scholar 

  79. McColl MD, Ramsay JE, Tait RC, Walker ID, McCall F, Conkie JA et al (1997) Risk factors for pregnancy associated venous thromboembolism. Thromb Haemost 78(4):1183–1188

    PubMed  CAS  Google Scholar 

  80. Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology (2001) Investigation and management of heritable thrombophilia. Br J Haematol 114(3):512–528

    Google Scholar 

  81. De Santis M, Cavaliere AF, Straface G, Di Gianantonio E, Caruso A (2006) Inherited and acquired thrombophilia: pregnancy outcome and treatment. Reprod Toxicol 22(2):227–233

    Article  PubMed  CAS  Google Scholar 

  82. Marik PE, Plante LA (2008) Venous thromboembolic disease and pregnancy. N Engl J Med 359(19):2025–2033

    Article  PubMed  CAS  Google Scholar 

  83. Greer IA (1999) Thrombosis in pregnancy: maternal and fetal issues. Lancet 353(9160):1258–1265

    Article  PubMed  CAS  Google Scholar 

  84. Rosendaal FR (1999) Venous thrombosis: a multicausal disease. Lancet 353(9159):1167–1173

    Article  PubMed  CAS  Google Scholar 

  85. Carbone JF, Rampersad R (2010) Prenatal screening for thrombophilias: indications and controversies. Clin Lab Med 30(3):747–760

    Article  PubMed  Google Scholar 

  86. NIH Consensus Development (1986) Prevention of venous thrombosis and pulmonary embolism. JAMA 256(6):744–749

    Google Scholar 

  87. Kierkegaard A (1983) Incidence and diagnosis of deep vein thrombosis associated with pregnancy. Acta Obstet Gynecol Scand 62(3):239–243

    Article  PubMed  CAS  Google Scholar 

  88. Treffers PE, Huidekoper BL, Weenink GH, Kloosterman GJ (1983) Epidemiological observations of thrombo-embolic disease during pregnancy and in the puerperium, in 56, 022 women. Int J Gynaecol Obstet 21(4):327–331

    Article  PubMed  CAS  Google Scholar 

  89. Rutherford S, Montoro M, Mc Gehee W, Strong T (1991) Thromboembolic disease associated with pregnancy: an 11-year review. Am J Obstet Gynecol 164(Suppl):186

    Google Scholar 

  90. Greer IA (1997) Epidemiology, risk factors and prophylaxis of venous thrombo-embolism in obstetrics and gynaecology. Baillieres Clin Obstet Gynaecol 11(3):403–430

    Article  PubMed  CAS  Google Scholar 

  91. McColl MD, Walker ID, Greer IA (1999) The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. Br J Obstet Gynaecol 106(8):756–766

    Article  PubMed  CAS  Google Scholar 

  92. Greer IA (2000) The challenge of thrombophilia in maternal-fetal medicine. N Engl J Med 342(6):424–425

    Article  PubMed  CAS  Google Scholar 

  93. Seligsohn U, Lubetsky A (2001) Genetic susceptibility to venous thrombosis. N Engl J Med 344(16):1222–1231

    Article  PubMed  CAS  Google Scholar 

  94. Preston FE, Rosendaal FR, Walker ID, Briet E, Berntorp E, Conard J et al (1996) Increased fetal loss in women with heritable thrombophilia. Lancet 348(9032):913–916

    Article  PubMed  CAS  Google Scholar 

  95. Rai R, Regan L (2000) Thrombophilia and adverse pregnancy outcome. Semin Reprod Med 18(4):369–377

    Article  PubMed  CAS  Google Scholar 

  96. Krabbendam I, Franx A, Bots ML, Fijnheer R, Bruinse HW (2005) Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature. Eur J Obstet Gynecol Reprod Biol 118(2):143–153

    Article  PubMed  Google Scholar 

  97. Coumans AB, Huijgens PC, Jakobs C, Schats R, de Vries JI, van Pampus MG et al (1999) Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum Reprod 14(1):211–214

    Article  PubMed  CAS  Google Scholar 

  98. Kutteh WH, Triplett DA (2006) Thrombophilias and recurrent pregnancy loss. Semin Reprod Med 24(1):54–66

    Article  PubMed  CAS  Google Scholar 

  99. MacCallum PK, Cooper JA, Martin J, Howarth DJ, Meade TW, Miller GJ (1998) Associations of protein C and protein S with serum lipid concentrations. Br J Haematol 102(2):609–615

    Article  PubMed  CAS  Google Scholar 

  100. Rai R, Backos M, Elgaddal S, Shlebak A, Regan L (2002) Factor V Leiden and recurrent miscarriage-prospective outcome of untreated pregnancies. Hum Reprod 17(2):442–445

    Article  PubMed  CAS  Google Scholar 

  101. Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT (2004) Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med 164(5):558–563

    Article  PubMed  Google Scholar 

  102. Meinardi JR, Middeldorp S, de Kam PJ, Koopman MM, van Pampus EC, Hamulyak K et al (1999) Increased risk for fetal loss in carriers of the factor V Leiden mutation. Ann Intern Med 130(9):736–739

    PubMed  CAS  Google Scholar 

  103. Pihusch R, Buchholz T, Lohse P, Rubsamen H, Rogenhofer N, Hasbargen U et al (2001) Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester. Am J Reprod Immunol 46(2):124–131

    Article  PubMed  CAS  Google Scholar 

  104. Mahjoub T, Mtiraoui N, Tamim H, Hizem S, Finan RR, Nsiri B et al (2005) Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages. Am J Hematol 80(1):12–19

    Article  PubMed  CAS  Google Scholar 

  105. Zotz RB, Gerhardt A, Scharf RE (2003) Inherited thrombophilia and gestational venous thromboembolism. Best Pract Res Clin Haematol 16(2):243–259

    Article  PubMed  Google Scholar 

  106. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88(10):3698–3703

    PubMed  CAS  Google Scholar 

  107. Nelen WL, Bulten J, Steegers EA, Blom HJ, Hanselaar AG, Eskes TK (2000) Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss. Hum Reprod 15(4):954–960

    Article  PubMed  CAS  Google Scholar 

  108. Nelen WL, Blom HJ, Steegers EA, den Heijer M, Eskes TK (2000) Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 74(6):1196–1199

    Article  PubMed  CAS  Google Scholar 

  109. Brandt JT, Triplett DA, Alving B, Scharrer I (1995) Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost 74(4):1185–1190

    PubMed  CAS  Google Scholar 

  110. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42(7):1309–1311

    Article  PubMed  CAS  Google Scholar 

  111. Out HJ, Bruinse HW, Christiaens GC, van Vliet M, de Groot PG, Nieuwenhuis HK et al (1992) A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies. Am J Obstet Gynecol 167(1):26–32

    PubMed  CAS  Google Scholar 

  112. Kutteh WH (1997) Antiphospholipid antibodies and reproduction. J Reprod Immunol 35(2):151–171

    Article  PubMed  CAS  Google Scholar 

  113. ACOG Committee on Practice Bulletins-Obstetrics (2005) ACOG Practice Bulletin #68: Antiphospholipid syndrome. Obstet Gynecol 106(5 Pt 1):1113–1121

    Google Scholar 

  114. Rand JH (2003) The antiphospholipid syndrome. Annu Rev Med 54:409–424

    Article  PubMed  CAS  Google Scholar 

  115. Rand JH, Wu XX, Guller S, Gil J, Guha A, Scher J et al (1994) Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. Am J Obstet Gynecol 171(6):1566–1572

    PubMed  CAS  Google Scholar 

  116. Shibata S, Harpel PC, Gharavi A, Rand J, Fillit H (1994) Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes. Blood 83(9):2532–2540

    PubMed  CAS  Google Scholar 

  117. Ermel LD, Marshburn PB, Kutteh WH (1995) Interaction of heparin with antiphospholipid antibodies (APA) from the sera of women with recurrent pregnancy loss (RPL). Am J Reprod Immunol 33(1):14–20

    PubMed  CAS  Google Scholar 

  118. Franklin RD, Kutteh WH (2003) Effects of unfractionated and low molecular weight heparin on antiphospholipid antibody binding in vitro. Obstet Gynecol 101(3):455–462

    Article  PubMed  CAS  Google Scholar 

  119. Di Simone N, Ferrazzani S, Castellani R, De Carolis S, Mancuso S, Caruso A (1997) Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera. Hum Reprod 12(9):2061–2065

    Article  PubMed  CAS  Google Scholar 

  120. Girardi G (2005) Heparin treatment in pregnancy loss: potential therapeutic benefits beyond anticoagulation. J Reprod Immunol 66(1):45–51

    Article  PubMed  CAS  Google Scholar 

  121. Friederich PW, Sanson BJ, Simioni P, Zanardi S, Huisman MV, Kindt I et al (1996) Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis. Ann Intern Med 125(12):955–960

    PubMed  CAS  Google Scholar 

  122. Oshiro BT, Silver RM, Scott JR, Yu H, Branch DW (1996) Antiphospholipid antibodies and fetal death. Obstet Gynecol 87(4):489–493

    Article  PubMed  CAS  Google Scholar 

  123. Alfirevic Z, Roberts D, Martlew V (2002) How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review. Eur J Obstet Gynecol Reprod Biol 101(1):6–14

    Article  PubMed  Google Scholar 

  124. Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361(9361):901–908

    Article  PubMed  Google Scholar 

  125. Lissalde-Lavigne G, Fabbro-Peray P, Cochery-Nouvellon E, Mercier E, Ripart-Neveu S, Balducchi JP et al (2005) Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case-control ‘NOHA first’ study. J Thromb Haemost 3(10):2178–2184

    Article  PubMed  CAS  Google Scholar 

  126. Roque H, Paidas MJ, Funai EF, Kuczynski E, Lockwood CJ (2004) Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost 91(2):290–295

    PubMed  CAS  Google Scholar 

  127. Rai R, Cohen H, Dave M, Regan L (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). Br Med J 314(7076):253–257

    Article  CAS  Google Scholar 

  128. Kutteh WH (1996) Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 174(5):1584–1589

    Article  PubMed  CAS  Google Scholar 

  129. Farquharson RG, Quenby S, Greaves M (2002) Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 100(3):408–413

    Article  PubMed  CAS  Google Scholar 

  130. Gris JC, Mercier E, Quere I, Lavigne-Lissalde G, Cochery-Nouvellon E, Hoffet M et al (2004) Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 103(10):3695–3699

    Article  PubMed  CAS  Google Scholar 

  131. Schuiling GA, Koiter TR, Faas MM (1997) Why pre-eclampisa? Hum Reprod 12(10):2087–2091

    Article  PubMed  CAS  Google Scholar 

  132. National high blood pressure education program working group report on high blood pressure in pregnancy (1990). Am J Obstet Gynecol 103(5 Pt 1):1691–1712

    Google Scholar 

  133. Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365(9461):785–799

    PubMed  Google Scholar 

  134. Mello G, Parretti E, Marozio L, Pizzi C, Lojacono A, Frusca T et al (2005) Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Hypertension 46(6):1270–1274

    Article  PubMed  CAS  Google Scholar 

  135. Branch DW, Silver RM, Blackwell JL, Reading JC, Scott JR (1992) Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 80(4):614–620

    PubMed  CAS  Google Scholar 

  136. Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD et al (2006) Thrombophilia in pregnancy: a systematic review. Br J Haematol 132(2):171–196

    Article  PubMed  CAS  Google Scholar 

  137. Martin JN Jr, Blake PG, Lowry SL, Perry KG Jr, Files JC, Morrison JC (1990) Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: how rapid is postpartum recovery? Obstet Gynecol 76(5 Pt 1):737–741

    Google Scholar 

  138. Torry DS, Wang HS, Wang TH, Caudle MR, Torry RJ (1998) Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol 179(6 Pt 1):1539–1544

    Article  PubMed  CAS  Google Scholar 

  139. Brown MA (1995) The physiology of pre-eclampsia. Clin Exp Pharmacol Physiol 22(11):781–791

    Article  PubMed  CAS  Google Scholar 

  140. He S, Bremme K, Blomback M (1997) Acquired deficiency of antithrombin in association with a hypercoagulable state and impaired function of liver and/or kidney in preeclampsia. Blood Coagul Fibrinolysis 8(4):232–238

    Article  PubMed  CAS  Google Scholar 

  141. McKay DG (1972) Hematologic evidence of disseminated intravascular coagulation in eclampsia. Obstet Gynecol Surv 27(6):399–417

    Article  PubMed  CAS  Google Scholar 

  142. Howie PW, Prentice CR, McNicol GP (1971) Coagulation, fibrinolysis and platelet function in pre-eclampsia, essential hypertension and placental insufficiency. J Obstet Gynaecol Br Commonw 78(11):992–1003

    Article  PubMed  CAS  Google Scholar 

  143. Redman CW, Denson KW, Beilin LJ, Bolton FG, Stirrat GM (1977) Factor-VIII consumption in pre-eclampsia. Lancet 2(8051):1249–1252

    Article  PubMed  CAS  Google Scholar 

  144. Schjetlein R, Abdelnoor M, Haugen G, Husby H, Sandset PM, Wisloff F (1999) Hemostatic variables as independent predictors for fetal growth retardation in preeclampsia. Acta Obstet Gynecol Scand 78(3):191–197

    Article  PubMed  CAS  Google Scholar 

  145. Higgins JR, Walshe JJ, Darling MR, Norris L, Bonnar J (1998) Hemostasis in the uteroplacental and peripheral circulations in normotensive and pre-eclamptic pregnancies. Am J Obstet Gynecol 179(2):520–526

    Article  PubMed  CAS  Google Scholar 

  146. Dusse LM, Carvalho MG, Getliffe K, Voegeli D, Cooper AJ, Lwaleed BA (2008) Increased circulating thrombomodulin levels in pre-eclampsia. Clin Chim Acta 387(1–2):168–171

    Article  PubMed  CAS  Google Scholar 

  147. Weiner CP, Brandt J (1982) Plasma antithrombin III activity: an aid in the diagnosis of preeclampsia-eclampsia. Am J Obstet Gynecol 142(3):275–281

    PubMed  CAS  Google Scholar 

  148. Dusse LM, Carvalho MG, Getliffe K, Voegeli D, Cooper AJ, Lwaleed BA (2008) Total plasma tissue factor pathway inhibitor levels in pre-eclampsia. Clin Chim Acta 388(1–2):230–232

    Article  PubMed  CAS  Google Scholar 

  149. Redman CW, Bonnar J, Beilin L (1978) Early platelet consumption in pre-eclampsia. Br Med J 1(6111):467–469

    Article  PubMed  CAS  Google Scholar 

  150. Rakoczi I, Tallian F, Bagdany S, Gati I (1979) Platelet life-span in normal pregnancy and pre-eclampsia as determined by a non-radioisotope technique. Thromb Res 15(3–4):553–556

    Article  PubMed  CAS  Google Scholar 

  151. Estelles A, Gilabert J, Grancha S, Yamamoto K, Thinnes T, Espana F et al (1998) Abnormal expression of type 1 plasminogen activator inhibitor and tissue factor in severe preeclampsia. Thromb Haemost 79(3):500–508

    PubMed  CAS  Google Scholar 

  152. Redman CW, Sacks GP, Sargent IL (1999) Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180(2 Pt 1):499–506

    Article  PubMed  CAS  Google Scholar 

  153. Mantovani A, Dejana E (1989) Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today 10(11):370–375

    Article  PubMed  CAS  Google Scholar 

  154. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW (1995) Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 102(1):20–25

    Article  PubMed  CAS  Google Scholar 

  155. Lim KH, Rice GE, de Groot CJ, Taylor RN (1995) Plasma type II phospholipase A2 levels are elevated in severe preeclampsia. Am J Obstet Gynecol 172(3):998–1002

    Article  PubMed  CAS  Google Scholar 

  156. Redman CW, Sargent IL (2003) Pre-eclampsia, the placenta and the maternal systemic inflammatory response–a review. Placenta 24(Suppl A):S21–S27

    Article  PubMed  Google Scholar 

  157. Takagi Y, Nikaido T, Toki T, Kita N, Kanai M, Ashida T et al (2004) Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 444(1):49–55

    Article  PubMed  CAS  Google Scholar 

  158. Tsukimori K, Fukushima K, Tsushima A, Nakano H (2005) Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnancies. Hypertension 46(4):696–700

    Article  PubMed  CAS  Google Scholar 

  159. Tsukimori K, Maeda H, Ishida K, Nagata H, Koyanagi T, Nakano H (1993) The superoxide generation of neutrophils in normal and preeclamptic pregnancies. Obstet Gynecol 81(4):536–540

    PubMed  CAS  Google Scholar 

  160. Huppertz B, Frank HG, Kingdom JC, Reister F, Kaufmann P (1998) Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol 110(5):495–508

    Article  PubMed  CAS  Google Scholar 

  161. Burrows RF, Hunter DJ, Andrew M, Kelton JG (1987) A prospective study investigating the mechanism of thrombocytopenia in preeclampsia. Obstet Gynecol 70(3 Pt 1):334–338

    PubMed  CAS  Google Scholar 

  162. Leduc L, Wheeler JM, Kirshon B, Mitchell P, Cotton DB (1992) Coagulation profile in severe preeclampsia. Obstet Gynecol 79(1):14–18

    PubMed  CAS  Google Scholar 

  163. McCrae KR, Samuels P, Schreiber AD (1992) Pregnancy-associated thrombocytopenia: pathogenesis and management. Blood 80(11):2697–2714

    PubMed  CAS  Google Scholar 

  164. Lok CA, Van Der Post JA, Sargent IL, Hau CM, Sturk A, Boer K et al (2008) Changes in microparticle numbers and cellular origin during pregnancy and preeclampsia. Hypertens Pregnancy 27(4):344–360

    Article  PubMed  CAS  Google Scholar 

  165. Sibai BM, Ramadan MK, Usta I, Salama M, Mercer BM, Friedman SA (1993) Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 169(4):1000–1006

    PubMed  CAS  Google Scholar 

  166. Miles JF Jr, Martin JN Jr, Blake PG, Perry KG Jr, Martin RW, Meeks GR (1990) Postpartum eclampsia: a recurring perinatal dilemma. Obstet Gynecol 76(3 Pt 1):328–331

    PubMed  Google Scholar 

  167. Nova A, Sibai BM, Barton JR, Mercer BM, Mitchell MD (1991) Maternal plasma level of endothelin is increased in preeclampsia. Am J Obstet Gynecol 165(3):724–727

    PubMed  CAS  Google Scholar 

  168. Yamanaka Y, Takeuchi K, Konda E, Samoto T, Satou A, Mizudori M et al (2002) Transient postpartum diabetes insipidus in twin pregnancy associated with HELLP syndrome. J Perinat Med 30(3):273–275

    PubMed  Google Scholar 

  169. Audibert F, Friedman SA, Frangieh AY, Sibai BM (1996) Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 175(2):460–464

    Article  PubMed  CAS  Google Scholar 

  170. Geary M (1997) The HELLP syndrome. Br J Obstet Gynaecol 104(8):887–891

    Article  PubMed  CAS  Google Scholar 

  171. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group (1994) CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 343(8898):619–629

    Google Scholar 

  172. Rotchell YE, Cruickshank JK, Gay MP, Griffiths J, Stewart A, Farrell B et al (1998) Barbados low dose aspirin study in pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol 105(3):286–292

    Article  PubMed  CAS  Google Scholar 

  173. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ et al (1999) Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 354(9181):810–816

    Article  PubMed  CAS  Google Scholar 

  174. Morris CD, Jacobson SL, Anand R, Ewell MG, Hauth JC, Curet LB et al (2001) Nutrient intake and hypertensive disorders of pregnancy: evidence from a large prospective cohort. Am J Obstet Gynecol 184(4):643–651

    Article  PubMed  CAS  Google Scholar 

  175. Atallah AN, Hofmeyr GJ, Duley L (2002) Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 10/1002(1):CD001059–1185

    Google Scholar 

  176. Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C (2000) Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish oil trials in pregnancy (FOTIP) team. Br J Obstet Gynaecol 107(3):382–395

    Article  CAS  Google Scholar 

  177. von Kries R, Junker R, Oberle D, Kosch A, Nowak-Gottl U (2001) Foetal growth restriction in children with prothrombotic risk factors. Thromb Haemost 86(4):1012–1016

    Google Scholar 

  178. Gopel W, Kim D, Gortner L (1999) Prothrombotic mutations as a risk factor for preterm birth. Lancet 353(9162):1411–1412

    Article  PubMed  CAS  Google Scholar 

  179. Lima F, Khamashta MA, Buchanan NM, Kerslake S, Hunt BJ, Hughes GR (1996) A study of sixty pregnancies in patients with the antiphospholipid syndrome. Clin Exp Rheumatol 14(2):131–136

    PubMed  CAS  Google Scholar 

  180. Yasuda M, Takakuwa K, Tokunaga A, Tanaka K (1995) Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol 86(4 Pt 1):555–559

    PubMed  CAS  Google Scholar 

  181. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J et al (1994) Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective study. Ann Intern Med 120(6):470–475

    PubMed  CAS  Google Scholar 

  182. Facco F, You W, Grobman W (2009) Genetic thrombophilias and intrauterine growth restriction: a meta-analysis. Obstet Gynecol 113(6):1206–1216

    PubMed  Google Scholar 

  183. Wiener-Megnagi Z, Ben-Shlomo I, Goldberg Y, Shalev E (1998) Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae. Am J Obstet Gynecol 179(6 Pt 1):1565–1567

    Article  PubMed  CAS  Google Scholar 

  184. van der Molen EF, Verbruggen B, Novakova I, Eskes TK, Monnens LA, Blom HJ (2000) Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy. Br J Obstet Gynaecol 107(6):785–791

    Article  Google Scholar 

  185. Facchinetti F, Marozio L, Grandone E, Pizzi C, Volpe A, Benedetto C (2003) Thrombophilic mutations are a main risk factor for placental abruption. Haematologica 88(7):785–788

    PubMed  CAS  Google Scholar 

  186. Prochazka M, Happach C, Marsal K, Dahlback B, Lindqvist PG (2003) Factor V Leiden in pregnancies complicated by placental abruption. Br J Obstet Gynaecol 110(5):462–466

    Article  CAS  Google Scholar 

  187. Rodger M (2010) Evidence base for the management of venous thromboembolism in pregnancy. Hematology Am Soc Hematol Educ Program 2010:173–180

    Article  PubMed  Google Scholar 

  188. Duhl AJ, Paidas MJ, Ural SH, Branch W, Casele H, Cox-Gill J et al (2007) Antithrombotic therapy and pregnancy: consensus report and recommendations for prevention and treatment of venous thromboembolism and adverse pregnancy outcomes. Am J Obstet Gynecol 197(5):457e1–457e21

    Article  CAS  Google Scholar 

  189. ACOG Practice Bulletin No. 102: management of stillbirth (2009) Obstet Gynecol 113(3):748–761

    Google Scholar 

  190. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J (2008) Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):844S–886S

    Article  PubMed  CAS  Google Scholar 

  191. Buser KB (2002) Laparoscopic surgery in the pregnant patient–one surgeon’s experience in a small rural hospital. J Soc Lap Surg 6(2):121–124

    Google Scholar 

  192. Bell RH Jr (2000) Gastrointestinal conditions. J Am Coll Surg 190(2):134–151

    Article  PubMed  Google Scholar 

  193. Angelini DJ (2003) Obstetric triage revisited: update on non-obstetric surgical conditions in pregnancy. J Midwifery Womens Health 48(2):111–118

    Article  PubMed  Google Scholar 

  194. Curet MJ (2000) Special problems in laparoscopic surgery. Previous abdominal surgery, obesity, and pregnancy. Surg Clin North Am 80(4):1093–1110

    Article  PubMed  CAS  Google Scholar 

  195. Palanivelu C, Rangarajan M, Senthilkumaran S, Parthasarathi R (2007) Safety and efficacy of laparoscopic surgery in pregnancy: experience of a single institution. J Laparoendosc Adv Surg Tech A 17(2):186–190

    Article  PubMed  Google Scholar 

  196. Amos JD, Schorr SJ, Norman PF, Poole GV, Thomae KR, Mancino AT et al (1996) Laparoscopic surgery during pregnancy. Am J Surg 171(4):435–437

    Article  PubMed  CAS  Google Scholar 

  197. Pucci RO, Seed RW (1991) Case report of laparoscopic cholecystectomy in the third trimester of pregnancy. Am J Obstet Gynecol 165(2):401–402

    PubMed  CAS  Google Scholar 

  198. Curet MJ, Allen D, Josloff RK, Pitcher DE, Curet LB, Miscall BG et al (1996) Laparoscopy during pregnancy. Arch Surg 131(5):546–550 discussion 50–51

    Article  PubMed  CAS  Google Scholar 

  199. Palanivelu C, Rangarajan M, Parthasarathi R (2006) Laparoscopic appendectomy in pregnancy: a case series of seven patients. J Soc Lap Surg 10(3):321–325

    Google Scholar 

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  1. Department of Anesthesia and Intensive Care, Pediatric Anesthesia and Intensive Care Section, “Policlinico” University Hospital, Catania, Italy

    Marinella Astuto, Valentina Taranto & Simona Grasso

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  1. Marinella Astuto
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    Giorgio Berlot

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Astuto, M., Taranto, V., Grasso, S. (2012). Hemostasis in Pregnancy and Obstetric Surgery. In: Berlot, G. (eds) Hemocoagulative Problems in the Critically Ill Patient. Springer, Milano. https://doi.org/10.1007/978-88-470-2448-9_10

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