Introduction to the Tracer-Based Study of Metabolism In Vivo

  • Andrea CaumoEmail author
  • Livio Luzi


The term homeostasiss was coined around 1930 by the American physiologist Walter Bradford Cannon and popularized in his book The Wisdom of the Body. Homeostasis refers to the attempts of living organisms to maintain certain physiological variables (temperature, acid-base balance, blood glucose, etc.) within narrow margins of variation.


Clearance Rate Metabolic System Tracer Dose Production Flux Accessible Compartment 
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Suggested Reading

  1. 1.
    Jacquez JA (1992) Theory of production rate calculations in steady and non-steady states and its applications to glucose metabolism. Am J Physiol 262:E779–E790PubMedGoogle Scholar
  2. 2.
    Cobelli C, Caumo A (1998) Using what is accessible to measure that which is not: necessity of model of system. Metabolism 47:1009–1035PubMedCrossRefGoogle Scholar
  3. 3.
    Zierler K (1999) Whole body glucose metabolism. Am J Physiol 276:E409–E426PubMedGoogle Scholar
  4. 4.
    Carson and Cobelli (2001) Modeling methodology for physiology and medicine. Academic Press, San DiegoGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Department of Sport Sciences, Nutrition and HealthUniversity of MilanMilanItaly

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