Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise

  • Stefano BenediniEmail author


Food is required as a fuel for the maintenance of energy-requiring processes that sustain life. Energy is needed to preserve the physicochemical environment of the body (homeostasis) and to sustain the organism’s activities. Although there are large inter-individual differences in energy requirements, much of the variance can be ascribed to fat-free mass, age, sex, and amount of physical activity. Genetic factors also appear to play an important role (see Chapters 1 and 4) [1].


Physical Activity Energy Expenditure Carnitine Acetyltransferase Adiposity Signal Total Daily Physical Activity Skeletal Muscle Fatty Acid 
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  1. 1.
    Ziegler EE, Filer Jr LJ (1996) Present knowledge in nutrition. ILSi, Washington, DCGoogle Scholar
  2. 2.
    Willett W (1998) Nutritional epidemiology. Oxford University Press, NYCrossRefGoogle Scholar
  3. 3.
    Krause MV, Maham LK (1984) Food, nutrition and diet therapy. W.B. Saunders, PhiladelphiaGoogle Scholar
  4. 4.
    Campbell NA, Williamson B, Heyden RJ (2006) Biology: exploring life. Pearson Prentice Hall, Boston, MassachusettsGoogle Scholar
  5. 5.
    McBride HM, Neuspiel M, Wasiak S (2006) Mitochondria: more than just a powerhouse. Curr Biol 16 (14):R551CrossRefGoogle Scholar
  6. 6.
    Voet, D, Voet JG, Pratt CW (2006). Fundamentals of biochemistry, 2nd edn. Wiley, Hoboken NJGoogle Scholar
  7. 7.
    Rich PR (2003) The molecular machinery of Keilin’s respiratory chain. Biochem Soc Trans 31 (6):1095–1105PubMedCrossRefGoogle Scholar
  8. 8.
    Benardot D (2006) Advanced sports nutrition. Human Kinetics, Champaign, ILGoogle Scholar
  9. 9.
    Benedini S (2009) The hypothalamus and energy balance. Sport Sci Health 5(2) 45–53CrossRefGoogle Scholar
  10. 10.
    Sahu A (2003) Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24(4):225–253PubMedCrossRefGoogle Scholar
  11. 11.
    Sahu A (2011) Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway. Neuroendocrinology. [Epub ahead of print]. doi: 10.1159/000326785Google Scholar
  12. 12.
    Meijer EP, Westerterp KR, Verstappen FT (1999) Effect of exercise training on total daily physical activity in elderly humans. Eur J Appl Physiol Occup Physiol 80:16–21PubMedCrossRefGoogle Scholar
  13. 13.
    Goran MI, Poehlman ET (1992) Endurance training does not enhance total energy expenditure in healthy elderly persons. Am J Physiol 263:950–957Google Scholar
  14. 14.
    Meijer G, Jannssen G, Westerterp K et al (1991) The effect of a 5-month endurance training programme on physical activity: evidence for a sex-difference in the metabolic response to exercise. Eur J Appl Physiol 62:11–17CrossRefGoogle Scholar
  15. 15.
    Hollowell RP, Willis LH, Slentz CA et al (2009) Effects of exercise training amount on physical activity energy expenditure. Med Sci Sports Exerc 41:1640–1644PubMedCrossRefGoogle Scholar
  16. 16.
    Slentz CA, Duscha BD, Johnson JL et al (2004) Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE—a randomized controlled study. Arch Intern Med 164:31–39PubMedCrossRefGoogle Scholar
  17. 17.
    Zurlo F, Lillioja S, Esposito-Del Puente A et al (1990) Low ratio of fat to carbohydrate oxidation as a predictor of weight gain: study of 24 h RQ. Am J Physiol 259:650–657Google Scholar
  18. 18.
    Marra M, Scalfi L, Contaldo F, Pasanisi F (2004) Fasting respiratory quotient as a predictor of long-term weight changes in non-obese women. Ann Nutr Metab 48:189–192PubMedCrossRefGoogle Scholar
  19. 19.
    Marra M, Scalfi L, Covino A, Esposito-Del Puente A, Contaldo F (1998) Fasting respiratory quotient as a predictor of weight changes in non-obese women. Int J Obes Relat Metab Disord 22:601–603PubMedCrossRefGoogle Scholar
  20. 20.
    Larson D, Ferraro R, Robertson D, Ravussin E (1995) Energy metabolism in weight stable postobese individuals. Am J Clin Nutr 62:735–739PubMedGoogle Scholar
  21. 21.
    Kelley DE, Goodpaster B, Wing RR, Simoneau JA (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130–E1141PubMedGoogle Scholar
  22. 22.
    Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism. 2000; 49(4):467–472PubMedCrossRefGoogle Scholar
  23. 23.
    Houmard JA. Intramuscular lipid oxidation and obesity. Am J Physiol Regul Integr Comp Physiol. 2008; 294(4):1111–1116.CrossRefGoogle Scholar
  24. 24.
    Slentz CA, Houmard JA, Kraus WE (2009) Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response. Obesity 17 Suppl 3:27–33CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Department of Sport Sciences, Nutrition and HealthUniversity of MilanMilanItaly
  2. 2.Research Center of MetabolismIRCCS Policlinico San Donato MilaneseMilanItaly

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