Abstract
Nowhere else in adult medicine does the world of congenital heart disease interdigitate so well with acquired heart disease as in the management of adult survivors of Tetralogy of Fallot (ToF). Progressive clinical dysfunction due to the combination of valvular pathology, abnormal loading conditions, maladap tive myocardial performance and abnormal interventricular and ventricular arterial coupling can give the keen observer insights that have application throughout the wider cardiovascular practice.
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References
Moorman A, Webb S, Brown NAet al (2003) Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart 89:806-814
Waldo KL, Kumiski DH, Wallis KT et al (2001) Conotruncal myocardium arises from a secondary heart field. Development 128:3179-3188
Nowotschin S, Liao J, Gage PJet al (2006) Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development 133:1565-1573
Lamers WH, Moorman AF (2002) Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis. Circ Res 91:93-103
Anderson RH, Webb S, Brown NAet al (2003) Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks. Heart 89:1110-1118
Duncan BW (2010) Tetralogy of Fallot with Pulmonary stenosis. In: Sellke, FW, del Nido PJ, Swanson SJ (eds) Surgery of the Chest. Saunders, Elsevier, Philadelphia, pp 1877–1896
Gatzoulis MA, Babu-Narayan SV (2011) Tetralogy of Fallot. In: Gatzoulis MD, Webb GD, Daubeney PEF (eds) Diagnosis and management of adult congenital heart disease: Saunders, Elsevier, Philadelphia, pp 316–327
Bodhey NK, Beerbaum P, Sarikouch Set al (2008) Functional analysis of the components of the right ventricle in the setting of tetralogy of Fallot. Circ Cardiovasc Imaging 1:141-147
Dore A, Houde C, Chan KL et al (2005) Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial. Circulation 112:2411-2416
Babu-Narayan SV, Uebing A, Davlouros PA et al (2010) Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation The APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). Int J Cardiol [Epub ahead of print]
Minegishi S, Kitahori K, Murakami A et al (2011) Mechanism of pressure-overload right ventricular hypertrophy in infant rabbits. Int Heart J 52:56-60
Urashima T, Zhao M, Wagner Ret al (2008) Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis. Am J Physiol Heart Circ Physiol 295:H1351-H1368
Reddy S, Osorio JC, Duque AMet al (2006) Failure of right ventricular adaptation in children with tetralogy of Fallot. Circulation 114:I37-I42
Oosterhof T, van Straten A, Vliegen HWet al (2007) Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance. Circulation 116:545-551
Frigiola A, Tsang V, Bull C et al (2008) Biventricular response after pulmonary valve replacement for right ventricular outflow tract dysfunction: is age a predictor of outcome? Circulation 118:S182-S190
Eyskens B, Reybrouck T, Bogaert J et al (2000) Homograft insertion for pulmonary regurgi tation after repair of tetralogy of fallot improves cardiorespiratory exercise performance. Am J Cardiol 85:221-225
Harrild DM, Berul CI, Cecchin F et al (2009) Pulmonary valve replacement in tetralogy of Fallot: impact on survival and ventricular tachycardia. Circulation 119:445-451
Ghai A, Silversides C, Harris Let al (2002) Left ventricular dysfunction is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot. J Am Coll Cardiol 40:1675-1680
Kempny A, Diller GP, Orwat S et al (2010) Right ventricular-left ventricular interaction in adults with Tetralogy of Fallot: A combined cardiac magnetic resonance and echocardiograph ic speckle tracking study. Int J Cardiol [Epub ahead of print]
Babu-Narayan SV, Goktekin O, Moon JCet al (2005) Late gadolinium enhancement cardiovascular magnetic resonance of the systemic right ventricle in adults with previous atrial redirection surgery for transposition of the great arteries. Circulation 111:2091-2098
Babu-Narayan SV, Kilner PJ, Li Wet al (2006) Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome. Circulation 113:405-413
Wald RM, Haber I, Wald R et al (2009) Effects of regional dysfunction and late gadolinium enhancement on global right ventricular function and exercise capacity in patients with repaired tetralogy of Fallot. Circulation 119:1370-1377
Das A, Banerjee RK, Gottliebson WM (2010) Right ventricular inefficiency in repaired tetralogy of Fallot: proof of concept for energy calculations from cardiac MRI data. Ann Biomed Eng 38:3674-3687
Lu JC, Cotts TB, Agarwal PP et al (2010) Relation of right ventricular dilation, age of repair, and restrictive right ventricular physiology with patient-reported quality of life in adolescents and adults with repaired tetralogy of fallot. Am J Cardiol 106:1798-1802
Knauth AL, Gauvreau K, Powell AJ et al (2008) Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair. Heart 94:211-216
Valente AM, Babu-Narayan S, Assenza GE et al (2011) International multicenter tetralogy of Fallot registry: Identifying predictors of adverse outcomes using cardiac MRI parameters. Journal of Cardiovascular Magnetic Resonance Imaging 13:187
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© 2012 Springer-Verlag Italia
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Assenza, G.E., Landzberg, M.J. (2012). Pathophysiology in Tetralogy of Fallot. In: Chessa, M., Giamberti, A. (eds) The Right Ventricle in Adults with Tetralogy of Fallot. Springer, Milano. https://doi.org/10.1007/978-88-470-2358-1_5
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DOI: https://doi.org/10.1007/978-88-470-2358-1_5
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