A coordination model for enhancing research on rare diseases

  • Michela Chessa
  • Vito FragnelliEmail author
  • Stefano Gagliardo
Part of the International Series in Operations Research & Management Science book series (ISOR, volume 173)


Rare diseases affect a great number of patients that suffer of the non existence of effective cures. Medical products for prevention, diagnosis or treatment of this kind of disorders are called orphan drugs and pharmaceutical industries have not a great interest under normal market conditions in developing and marketing products for a small number of patients. The Orphan Drug Act and the Regulation on Orphan Medicinal Products played a relevant role in encouraging the development of new orphan drugs, as in America as in Europe. In this chapter we propose that pharmaceutical industries coordinate their researches in order to avoid that two or more of them study a new molecule for the same disease, with the aim of further enhancing the research on rare diseases.


rare disease orphan drug multiple knapsack problem college admissions problem 


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Michela Chessa
    • 1
  • Vito Fragnelli
    • 2
    Email author
  • Stefano Gagliardo
    • 3
  1. 1.Department of MathematicsUniversity of MilanoMilanoItaly
  2. 2.Department of Sciences and Technological InnovationUniversity of Eastern PiedmontAlessandriaItaly
  3. 3.Department of MathematicsUniversity of GenovaGenovaItaly

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