Because of the requirement for osmotic equilibrium between the cells and the extracellular fluid, any alteration in extracellular osmolality is accompanied by an identical change in intracellular osmolality, with a concomitant change in cellc volume and possibly in cell function [1].


Diabetes Insipidus Total Body Water Urine Osmolality Nephrogenic Diabetes Insipidus Central Diabetes Insipidus 
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  1. 1.
    Lang F, Ritter M et al (1993) The biological significance of cell volume. Renal Physiol Biochem 16:48–56PubMedGoogle Scholar
  2. 2.
    Snyder NA, Feigal DW, Arieff AI (1987) Hypernatremia in elderly patients: a heterogeneous, morbid and iatrogenic entity. Ann Int Med 107:309–314PubMedCrossRefGoogle Scholar
  3. 3.
    Kinne RKH, Ruhfus B et al (1995) Renal organic osmolytes: signal transduction pathways and release mechanisms. In: De Santo NG, Capasso G. Acid base and electolyte balance. IISS Ed. Napoli, pp 237–242Google Scholar
  4. 4.
    Daugirdas JT, Kronfol NO et al (1989) Hyperosmolar coma: cellular dehydration and the serum sodium concentration. Ann Intern Med 110:855–857PubMedCrossRefGoogle Scholar
  5. 5.
    Lewis SA, Donaldson P (1990) Ion channels and cell volume regulation: chaos in an organized system. News in Physiological Sciences 5:112–118Google Scholar
  6. 6.
    Schrier RW (1988) Pathogenesis of sodium and water retention in high output and low output cardiac failure, nephrotic syndrome, cirrhosis and pregnancy. N Engl J Med 319:1065–1073PubMedCrossRefGoogle Scholar
  7. 7.
    Arieff AI, Guisado R (1976) Effects on the central nervous system of hypernatremic and hyponatremic states. Kidney Int 10:104–111PubMedCrossRefGoogle Scholar
  8. 8.
    Lien YHH, Shapiro JI et al (1990) Effects of hypernatremia on organic brain osmoles. J Clin Invest 85:1427–1433PubMedCrossRefGoogle Scholar
  9. 9.
    Levine SN, Sanson TH (1989) Treatment of hyperglicaemic hyperosmolar non-ketotic syndrome. Drugs 38:462–472PubMedCrossRefGoogle Scholar
  10. 10.
    Cruz Caudillo JC, Sabatini S (1995) Diabetic hyperosmolar syndrome. Nephron 69:201–210PubMedCrossRefGoogle Scholar
  11. 11.
    Popli S, Leehey DJ et al (1990) Asymptomatic, non ketotic, severe hyperglycemia with hyponatremia. Arch Intern Med 150:1962–1964PubMedCrossRefGoogle Scholar
  12. 12.
    Vin-Christian K, Arieff AI (1993) Diabetes insipidus, massive polyuria and hypernatremia leading to permanent brain damage. Am J Med 94:341–345PubMedCrossRefGoogle Scholar
  13. 13.
    Elisaf M et al (1989) Survival after severe iatrogenic hypernatremia. Am J Kidney Disease 14:230–234Google Scholar
  14. 14.
    Lustman CC, Guerin JJ et al (1991) Hyperosmolar non ketotic syndrome associated with rhabdomyolysis and acute kidney failure. Diabetes Care 14:146–147PubMedGoogle Scholar
  15. 15.
    Cserr HF, De Pasquale et al (1987) Regulation of brain water and electrolytes during acute hyperosmolality in rats. Am J Physiol 253:F522-F526PubMedGoogle Scholar
  16. 16.
    Wang LM, Tsai ST et al (1994) Rhabdomyolysis in diabetic emergencies. Diabetes Research Clinical Practice 26(3):209–214CrossRefGoogle Scholar
  17. 17.
    Smithline N, Gardner KD (1976) Gaps-anionic and osmolal. JAMA 236:1594–1597PubMedCrossRefGoogle Scholar
  18. 18.
    Kruse JA (1992) Methanol poisoning. Intensive Care Med 391–397Google Scholar
  19. 19.
    Ayus JC, Krothapalli R, Freiberg M (1990) Role of hypercatabolism in mortality associated with chronic hypernatremia in rats. Kidney Int 36:263–266Google Scholar
  20. 20.
    Haussinger D, Roth E et al (1993) Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet 341:1330–1333PubMedCrossRefGoogle Scholar
  21. 21.
    Garland A, Jordan JE et al (1995) Hypertonicity, but not hypotermia, elicits substance P release from rat C-fiber neurons in primary culture. J Clin Invest 95:66CrossRefGoogle Scholar
  22. 22.
    Richardson DW, Robinson AG (1985) Desmopressin. Ann Intern Med 103:228–233PubMedCrossRefGoogle Scholar
  23. 23.
    Chanson P, Jedynak CP et al (1988) Management of early postoperative diabetes insipidus with parenteral desmopressin. Acta Endocrinol 117:513–519PubMedGoogle Scholar

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© Springer-Verlag Italia 1997

Authors and Affiliations

  • F. Schiraldi
  • F. Paladino

There are no affiliations available

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