Abstract
There is overwhelming evidence that in the post myocardial infarction (MI) setting β-blockers (BB) are of benefit (in terms of safety and efficacy): they reduce recurrent MI, sudden death (SD) mortality, total mortality especially in patients with depressed ventricular function [1–14].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
The Norwegian Multicentre Study Group (1981) Timolol induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 309: 801–807
Beta-blockers Heart Attack Trial Research Group (1982) A randomized trial of propranolol in patients with acute myocardial infarction. Mortality results. JAMA 247: 1707–1714
Herlitz J, Wilhelmsen C, Holmberg S et al (1984) The Goteborg Metoprolol Trial in Acute Myocardial Infarction. Am J Cardiol 53 (suppl D): 1D–50D
The Miami Trial Research Group (1985) Metoprolol in Acute Myocardial Infarction (MIAMI). A randomized placebo-controlled international trial. Eur Heart J 6: 199–226
Yusuf S, Peto R, Lewis J et al (1985) Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Progr Cardiovasc Dis 27: 335–371
The Beta-blockers Pooling Project Research Group (1988) The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomized trials in postinfarction patients. Eur Heart J 9: 8–16
Boissel JP, Leizorovicz A, Picolet H et al (1990) Secondary prevention after high risk acute myocardial infarction with low dose acebutolol. Am J Cardiol 66: 251–260
Olson G (1992) Metoprolol induced reduction in postinfarction mortality: pooled results from five double-blind randomized trials. Eur Heart J 13: 28–32
Pitt B (1992) The role of ß-adrenergic blocking agents in preventing sudden cardiac death. Circulation 85 (suppl I): 1107–1115
Yusuf S, Lessem J, Jha P et al (1993) Primary and secondary prevention of myocardial infarction and strokes: an update of randomly allocated, controlled trials. J Hypertens 11 (suppl 4): S61–S63
Held P (1993) Effects of betablockers on ventricular dysfunction after myocardial infarction: tolerability and survival effects. Am J Cardiol 71 (9): 39C–44C
Viscoli CM, Horwitz RI, Singer BH (1993) Beta-blockers after myocardial infarction: influence of first year clinical course on long term effectiveness. Ann Intern Med 118: 99–105
Teo KK, Yusuf S, Furberg CD (1993) Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. JAMA 270: 1589–1595
Castaigne A, Carville AF, Chazouilleres AF et al (1995) Le traitement médical après l’infarctus du myocarde: ordonnance réflexe ou ordonnance réfléchie. Arch Mal Coeur 88 (III): 45–49
Reiffel J, Estes NAM III, Waldo AL et al (1994) A consensus report on antiarrhythmic drug use. Clin Cardiol 17: 103–110
Ryan TJ, Anderson JL, Antman EM et al (1996) ACC/AHA guidelines for the management of patients with acute myocardial infarction: executive summary. Circulation 94: 2341–2350
Cairns JA, Connolly SJ (1995) The problem of asymptomatic ventricular arrhythmias among survivors of acute myocardial infarction: role of amiodarone. ACC Current J Review 4 (2): 32–34
Kennedy HL, Brooks MM, Barker AH et al (1994) Beta-Blocker therapy in the Cardiac Arrhythmia Suppression Trial. Am J Cardiol 74: 674–680
Kjekshus J, Gilpin E, Cali G et al (1990) Diabetic patients and beta-blockers after acute myocardial infarction. Eur Heart J 10: 423–428
Forman DE, Gutierrez Bernal JL, Wey JY (1992) Management of acute myocardial infarction in the very elderly. Am J Med 93: 315–326
Yusuf S, Wittes J, Probstifield J (1990) Evaluating effects of treatment in subgroups of patients within a clinical trial: the case of non-Q wave myocardial infarction and beta-blockers. Am J Cardiol 66: 220–222
Glamann DB, Lange RA, Hillis LD (1991) Beneficial effects of long term beta-blockade after acute myocardial infarction in patients without anterograde flow in the infarct artery. Am J Cardiol 68: 150–154
Singh BN (1996) New antiarrhythmic drugs for ventricular arrhythmias: do they work? In: Raviele A (ed) Cardiac arrhythmias 1995. Springer, Berlin Heidelberg New York, pp 31–38
Echt DS, Liebson PR, Mitchell LB et al (1991) Mortality and morbidity in patients receiving flecainide, encainide and placebo: the Cardiac Arrhytmia Suppression Trial. N Engl J Med 324: 781–788
Schwartz PJ (1996) What have we learned from the SWORD trial? Can potassium channel blockers reduce sudden cardiac death? In: Raviele A (ed) Cardiac arrhythmias 1995. Springer, Berlin Heidelberg New York, pp 39–42
Avanzini F, Latini R, Maggioni A et al (1995) Antiarrhythmic drug prescription in patients after myocardial infarction in the last decade. Arch Intern Med 155: 1041–1045
Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 273: 1450–1456
Ferguson D (1966) Meeting highlights. Circulation 94: 3–6
Naccarella FF, Palmieri M, Barbato G et al (1997) Critical evaluation of controlled clinical trials of antiarrhythmic therapy in the prevention of sudden death. In: Santini M (ed) Progress in clinical pacing 1996. Futura Media Services, New York, pp 531–546
Maggioni A (1997) personal communication
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Italia
About this chapter
Cite this chapter
Lunati, M., Gasparini, M., Magenta, G., Cattafi, G., Gadaleta, G. (1998). Beta-blockers Prevent Sudden Death: so Why Is Their Use Limited after Myocardial Infarction?. In: Raviele, A. (eds) Cardiac Arrhythmias 1997. Springer, Milano. https://doi.org/10.1007/978-88-470-2288-1_29
Download citation
DOI: https://doi.org/10.1007/978-88-470-2288-1_29
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2290-4
Online ISBN: 978-88-470-2288-1
eBook Packages: Springer Book Archive