Abstract
Microcirculation is the collective name for the smallest peripheral section of the circulatory system; it comprehends arterioles, capillaries and venules, each with its own structural and functional characteristics.
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References
Zweifach BW (1961) Functional behavior of the microcirculation. Thomas, Springfield
Mortillaro NA (1983) The physiology and pharmacology of the microcirculation. Academic Press, New York
Gaehtgen P (1990) Microcirculatory control of tissue oxygenation. In: Vincent JL (ed) Update in intensive care and emergency medicine. Springer, Berlin, pp 44–52
Zweifach BW, Thomas L (1957) The relationship between the vascular manifestations of shock induced by endotoxin, trauma and hemorrhage. J Exper Med 106:385–401
Thomas L (1954) The physiological disturbances produced by endotoxin. Rev Physiol 16: 467–490
Astiz ME, De Gent ME, Lin R (1995) Microvascular function and rheologic changes in hyperdynamic sepsis. Crit Care Med 23:265–271
Rogers F, Dunn R, Barrett J et al (1985) Alterations of capillary blood flow during sepsis. Circ Shock 15:105–110
Greenberg S, Curro FA, Tanaka PT (1983) Regulation of vascular smooth muscles of the microcirculation. In: Mortillaro NA (ed) The physiology and pharmacology of the microcirculation. Academic Press, New York, pp 39–141
Evequoz D, Waeber B, Corder R et al (1987) Markedly reduced blood pressure responsiveness in endotoxemic rats: reversal by neuropeptide Y. Life Sci 41:2573–2580
Parratt JR (1989) Alterations in vascular reactivity in sepsis and endotoxemia. In: Vincent JL (ed) Update in intensive care and emergency medicine. Springer, Berlin, pp 27–40
Christmas JW, Lancaster LH, Blackwell TS (1988) Nuclear factor kB: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Int Care Med 24:1131–1138
Essani NA, Fisher MA, Jaeschke H (1997) Inhibition of NF-kB activation by dimethylsulfoxide correlates with the suppression of TNF-α formation, reduced ICAM gene transcription and protection against endotoxin-induced liver injury. Shock 7:90–96
Shu FL, Xiaobing YE, Malik AB (1999) Pirrolidine dithiocarbamate prevents I-kB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Molec Pharmacol 55:658–677
Schmid W, Stenzel K, Gebhard MM et al (1999) C 1-esterase inhibitor and its effects on endotoxin induced leukocyte adherence and plasma extravasation in postcapillary veins. Surgery 125:280–287
Suzuki YI, Packer RL (1993) Inhibition of NF-kB activation by vitamin E derivatives. Biochem Biophys Res Commun 193:277–283
Scannell G (1996) Leukocyte responses to hypoxic/ischemic conditions. New Horiz 4: 179–183
Minghini A, Britt LD, Hill MA (1998) Interleukin 1 and interleukin 6 mediate muscle arterial vasodilation: “in vitro” versus ”in vivo“ studies. Shock 9:210–215
Lou J, Donati YAR, Juillard P et al (1997) Platelets play an important role in TNF-induced microvascular endothelial cell pathology. Am J Pathol 151:1397–1405
Maekawa K, Futami S, Nishida M et al (1998) Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD 116. J Trauma 44:460–467
Kubes P, Suzuki K, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88:4651–4655
Kurose T, Anderson DC, Miyasaka M et al (1994) Molecular determinants of reperfusion induced leukocyte adhesion and vascular protein leakage. Circ Res 74:336–343
Kurose I, Kubes S, Wolf R et al (1993) Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage. Circ Res 73:164–171
Granger DN (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255:H 1269-H 1275
Cohen RA, Vanhoutte PM (1995) Endothelium dependent hyperpolarization. Beyond nitric oxide and cGMP. Circulation 92:3337–3349
Rubanyi GM, Polokoff MA (1994) Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 46:325–415
Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:20022012
Radomski MW, Palmer RMJ, Moncada S (1987) Endogenous NO inhibits human platelet adhesion to vascular endothelium. Lancet 2:1057–1058
Radomski MW, Palmer RMJ, Moncada S (1990) Characterization of the L-arginine-nitric oxide pathway in human platelet. Brit J Pharmacol 101:325–328
Clancy RM, Leszczynska-Piziak L, Abramson SH (1992) Nitric oxide, an endothelial cell relaxing factor, inhibits neutrophil superoxide anion production a direct action on the NADPH oxidase. J Clin Invest 90:1116–1121
Suzuki M, Asako H, Kubes P et al (1991) Neutrophil-derived oxidants promote leukocyte adherence in post-capillary venules. Microvasc Res 42:125–138
Mitchell DJ, Jingcheng YU, Kabel T (1998) Local L-NAME decreases blood flow and increases leukocyte adhesion via CD18. Am J Physiol 274:H 1264-H 1268
Baldwin AL, Thurston G, Al Naemi H (1998) Inhibition of nitric oxide synthesis increases venular permeability and alters endothelial actyn cytoskeleton. Am J Physiol 274:H1776H 1798
Kirkeboen KA, Strand OA (1999) The role of nitric oxide in sepsis: an overview. Acta Anaesth Scand 43:275–288
Spain DA, Wilson MA, Bar-Natan MF et al (1994) Role of nitric oxide in the small intestinal microcirculation during bacteremia. Shock 2:41–46
Niu X, Smith W, Kubes P (1994) Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res 74:1133–1140
Arndt H, Russell JB, Kurose I et al (1993) Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology 105:675–680
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Novelli, G.P. (2000). Biochemical Regulation of the Microcirculation. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2284-3_3
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DOI: https://doi.org/10.1007/978-88-470-2284-3_3
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0096-4
Online ISBN: 978-88-470-2284-3
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