Abstract
The ability to generate and respond to signaling molecules establishes a mechanism for regulated cell-to-cell communication. Cells coordinate their growth and proliferation with autocrine and paracrine signaling by means of low molecular weight polypeptides called cytokines. Innate or natural immunity is a highly conserved defense mechanism against infections found in all multicellular organisms [1]. The inflammatory reaction is a fundamental component of the innate immune response, and its most proximal expression is characterized by the elaboration of proinflammatory cytokines — tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Response to cytokines is generally viewed as exclusive to cells containing a defined nucleus, since cytokines are intended to work on welldefined eukaryotic cells with consequent signal transduction events.
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References
Suffredini AF, Fantuzzi G, Badolato R et al (1999) New insights into the biology of the acute phase response. J Clin Immunol 19(4):203–214
Meduri GU, Estes RJ (1995) The pathogenesis of ventilator-associated pneumonia: II. The lower respiratory tract. Intensive Care Med 21(5):452–461
Meduri GU (1996) The role of the host defence response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment. Eur Respir J 9(12):2650–2670
Rossi AG, Haslett C (1998) Inflammation, cell injury, and apoptosis. In: Said SI (ed) Proinflammatory and antiinflammatory peptides, lung biology in health and disease. Marcel Dekker, New York, pp 9–24
Bone RC, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101(6):1644–1655
Montgomery AB, Stager MA, Carrico CJ et al (1985) Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 132(3):485–489
Andrews CP, Coalson JJ, Smith JD et al (1981) Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury. Chest 80(3):254–258
Seidenfeld JJ, Pohl DF, Bell RC et al (1986) Incidence, site, and outcome of infections in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 134(1):12–16
Bell RC, Coalson JJ, Smith JD et al (1983) Multiple organ system failure and infection in adult respiratory distress syndrome. Ann Intern Med 99:293–298
Suchyta MR, Clemmer TP, Elliott CG et al (1992) The adult respiratory distress syndrome. A report of survival and modifying factors [see comments] . Chest 101(4):1074–1079
Meduri GU (1993) Late adult respiratory distress syndrome. New Horiz 1(4):563–577
Bone RC (1996) Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med 24(1):163–172
Headley AS, Tolley E, Meduri GU (1997) Infections and the inflammatory response in acute respiratory distress syndrome. Chest 111(5):1306–1321
Meduri GU, Headley S, Kohler G et al (1995) Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107(4):1062–1073
Romani L, Mencacci A, Cenci E et al (1996) Imparied neutrophil response and CD4+ T helper cell development in interleukin 6-deficient mice infected with Candida albicans. J Exp Med 183:1345–1355
Wagner HNJ, Bennett ILJ, Lasagna L et al (1956) The effect of hydrocortisone upon the course of pneumococcal pneumonia treated with penicillin. Bull Johns Hopkins Hosp 98: 197–215
Meduri GU, Reddy RC, Stanley T et al (1998) Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling. Am J Respir Crit Care Med 158(3):870–875
Rouby JJ, Martin De Lassale E, Poete P et al (1992) Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis 146(4):1059–1066
Johanson WG Jr, Seidenfeld JJ, Gomez P et al (1988) Bacteriologic diagnosis of nosocomial pneumonia following prolonged mechanical ventilation. Am Rev Respir Dis 137(2):259–264
Chastre J, Fagon JY, Bornet-Lecso M et al (1995) Evaluation of bronchoscopic techniques for the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 152(1):231–240
Meduri GU, Kohler G, Headley S et al (1995) Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest 108(5):1303–1314
Fox-Dewhurst R, Alberts MK, Kajikawa O et al (1997) Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. Am J Respir Crit Care Med 155 (6):2030–2040
Martin TR, Pistorese BP, Hudson LD et al (1991) The function of lung and blood neutrophils in patients with the adult respiratory distress syndrome. Implications for the pathogenesis of lung infections. Am Rev Respir Dis 144:254–262
Chollet-Martin S, Jourdain B, Gibert C et al (1996) Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am J Respir Crit Care Med 154(3 Pt 1):594–601
Clawson CC, Repine JE (1976) Quantitation of maximal bactericidal capability in human neutrophils. J Lab Clin Med 88(2):316–327
Kotwal GJ (1997) Microorganisms and their interaction with the immune system. J Leukoc Biol 62(4):415–429
Porat R, Clark BD, Wolff SM et al (1991) Enhancement of growth of virulent strains of Escherichia coli by interleukin-l. Science 254(5030):430–432
Zav’yalov VP, Chernovskaya TV, Navolotskaya EV et al (1995) Specific high affinity binding of human interleukin 1 beta by Caf 1 A usher protein of Yersinia pestis. FEBS Lett 371(1): 65–68
Luo G, Niesel DW, Shaban RA et al (1993) Tumor necrosis factor alpha binding to bacteria: evidence for a high-affinity receptor and alteration of bacterial virulence properties. Infect Immun 61(3):830–835
Hogan JS, Todhunter DA, Smith KL et al (1993) Growth responses of coliform bacteria to recombinant bovine cytokines. J Dairy Sci 76(4):978–982
Denis M, Campbell D, Gregg EO (1991) Interleukin-2 and granulocyte-macrophage colonystimulating factor stimulate growth of a virulent strain of Escherichia coli. Infect Immun 59(5): 1853–1856
Hultgren O, Kopf M, Tarkowski A (1998) Staphylococcus aureus-induced septic arthritis and septic death is decreased in IL-4-deficient mice: role of IL-4 as promoter for bacterial growth. J Immunol 160(10):5082–5087
Denis M, and Gregg EO (1990) Recombinant tumour necrosis factor-alpha decreases whereas recombinant interleukin-6 increases growth of a virulent strain of Mycobacterium avium in human macrophages. Immunology 71(1):139–141
Shiratsuchi H, Johnson JL, Ellner JJ (1991) Bidirectional effects of cytokines on the growth of Mycobacterium avium within human monocytes. J Immunol 146(9):3165–3170
Park DR, Skerrett SJ (1996) IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-y: differential responses of blood monocytes and alveolar macrophages. J Immunol 157(6):2528–2538
Meduri GU, Kanangat S, Stefan J et al (1999) Cytokines IL-1 ß, IL-6, and TNF-α enhance in vitro growth of bacteria. Am J Respir Crit Care Med 161:961–967
Kanangat S, Meduri GU, Tolley EA et al (1999) Effects of cytokines and endotoxin on the intracellular growth of bacteria. Infect Immun 67(6):2834–2840
Porat RB, Clark D, Wolf SM et al (1992) IL-1β3 and Escherichia coli [Letter]. Science 258:1562–1563
Meduri GU, Kanangat S, Tolley E et al (1999) Effects of glucocorticoids on the intracellular growth of bacteria in lipopolysaccharide-primed human monocytic cells. First international congress on cytokines/chemokines in infectious disease: final program and abstract book. National Institute of Allergy & Infectious Diseases and International Immunocompromised Host Society, Bethesda, Maryland, pp 131
Falkow S (1997) Perspectives series: host/pathogen interactions. Invasion and intracellular sorting of bacteria: searching for bacterial genes expressed during host/pathogen interactions. J Clin Invest 100(2):239–243
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Meduri, G.U. (2000). A Paradigm Shift: The Bidirectional Effect of Inflammation on Bacterial Growth. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2284-3_16
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DOI: https://doi.org/10.1007/978-88-470-2284-3_16
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