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The Kidney in Sepsis

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Sepsis and Organ Dysfunction

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Abstract

The kidney is a significant target organ for the sepsis syndrome and, depending on the definitions used, acute renal failure (ARF) occurs in as many as 15% of patients with critical illness [1] and sepsis appears to be a contributing factor in as many as 43 %[2] . In addition, the kidney is usually the organ that fails first [3]. While the mortality rate of isolated acute renal failure is approximately 10 to 15%, ARF in the setting of sepsis carries a mortality rate between 50 to 90% according to published series. In a recent study [4], the mortality rate among 253 cases of ARF treated in the ICU was 71.5% whereas it was 31.5% among the 495 cases of ARF treated in a non-ICU setting (p = 0.001).

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Authors
  1. J. A. Kellum
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Editor information

Editors and Affiliations

  1. Department of Surgery, Health Sciences Center, Saint Louis University, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, Cattinara Hospital, University of Trieste, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

  3. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium

    J.-L. Vincent M.D.

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© 2000 Springer-Verlag Italia

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Kellum, J.A. (2000). The Kidney in Sepsis. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2284-3_10

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  • DOI: https://doi.org/10.1007/978-88-470-2284-3_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0096-4

  • Online ISBN: 978-88-470-2284-3

  • eBook Packages: Springer Book Archive

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