Abstract
Recent data suggest that active inflammation and/or infection in the coronary arteries may play a role in ischemic heart disease (IHD) [1, 2]. The infectious theory has been suggested by epidemiological, serological, immunohistochemical and in situ hybridization studies, which indicated a possible etiologic role of some viruses and bacteria in the development of atherosclerotic lesions [3–5]. Among the micro-organisms potentially implicated, Chlamydia pneumoniae is the most extensively studied in the literature [6–9].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Nieminen MS, Mattila K, Valtonen V (1993) Infection and inflammation as a risk factor for myocardial infarction. Eur Heart J 14[Suppl K]: 12–16
Alexander RW (1994) Inflammation and coronary artery disease. N Engl J Med 331: 468–469
Beneditt EP, Barret T, McDougall JK (1983) Viruses and etiology of atherosclerosis. Proc Natl Acad Sci USA 80: 6386–6389
Pesonen E, Siitonen O (1981) Acute myocardial infarction precipitated by infectious diseases. Am Heart J 101: 512–513
Spodick DH, Flessas AP, Johnson MM (1984) Association of acute respiratory symptoms with onset of acute myocardial infarction: prospective investigation of 150 consecutive patients and matched control patients. Am J Cardiol 53: 481–482
Saikku P (1993) Chlamydia pneumoniae as a risk factor in acute myocardial infarction. Eur Heart J 14[Suppl K]: 62–65
Saikku P, Leinonen M, Mattila K et al (1988) Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet ii: 983–986
Shor A, Kuo C-C, Patton DL (1992) Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J 82: 158–161
Kuo C-C, Shor A, Campbell LA et al (1993) Demonstration of Chlamydia pneumoniaein atherosclerotic lesions of coronary arteries. J Infect Dis 167: 845–849
Mendall MA, Goggin PM, Molineaux N et al (1994) Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 71: 437–439
Aceti A, Mazzacurati G, Amendola MA et al (1996) H. pylori and C. pneumoniae infections may account for most acute coronary syndrome. BMJ 313: 428–429
Morgando A, Sanseverino P, Perotto C et al (1995) Helicobacter pylori seropositivity in myocardial infarction. Lancet 345: 1380 (letter)
Patel P, Carrington D, Strachan DP et al (1994) Fibrinogen: a link between chronic infection and coronary heart disease. Lancet 343: 1634–1635
Wald NJ, Law MR, Morris JK et al (1997) Helicobacter pylori infection and mortality from ischaemic heart disease: negative result from a large, prospective study. BMJ 315: 1199–1201
Gupta S, Leatham EW, Carrington D et al (1997) Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation 96: 404–407
Gurfinkel E, Bozovich G, Daroca A et al (1997) Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. Lancet 350: 404–407
Agen C, Danesi R, Blandizzi C et al (1993) Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role. Agents Actions 38:(1–2)85–90
Liuzzo G, Biasucci LM, Gallimore JR et al (1994) The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 331: 417–424
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Italia, Milano
About this chapter
Cite this chapter
Allegra, L., Cosentini, R., Tarsia, P. (1999). Clarithromycin Treatment of Helicobacter pylori and Chlamydia pneumoniae Infections Decreases Fibrinogen Plasma Level in Patients with Ischemic Heart Disease. In: Allegra, L., Blasi, F. (eds) Chlamydia pneumoniae. Springer, Milano. https://doi.org/10.1007/978-88-470-2280-5_19
Download citation
DOI: https://doi.org/10.1007/978-88-470-2280-5_19
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0047-6
Online ISBN: 978-88-470-2280-5
eBook Packages: Springer Book Archive