Abstract
Infections in critically ill patients admitted to the intensive care unit (ICU) develop mainly endogenously, and are less frequently exogenous: they are almost invariably preceded by oropharyngeal and gastrointestinal carriage of potentially pathogenic microorganisms (PPMs) [1]. Carriage and subsequent overgrowth of PPMs in the alimentary canal are the first steps in the pathogenesis of endogenous infections; migration of PPMs into the internal organs (e.g., lower airways, bladder) may result in colonization and, eventually, infection. “Community” and “hospital” PPMs carried by the patient upon admission are the causative agents of primary endogenous infections, while “hospital” PPMs acquired by the patient during the ICU stay are responsible for secondary endogenous infections. Exogenous infections are caused mainly by hospital PPMs not carried by the patient at all [1].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
van Saene HKF, Damjanovic V, Murray AE, de la Cal MA (1996) How to classify infections in intensive care units–the carrier state, a criterion whose time has come? J Hosp Infect 33: 1–12
Baxby D, van Saene HKF, Stoutenbeek CP, Zandstra DF (1996) Selective decontamination of the digestive tract: 13 years on, what it is, and what it is not. Intensive Care Med 22: 699–706
Silvestri L, Mannucci F, van Saene HKF (2000) Selective decontamination of the digestive tract: a life saver. J Hosp Infect 45: 185–190
D’Amico R, Pifferi S, Leonetti C et al (1998) Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. BMJ 316: 1275–1285
Brun-Bruisson C, Doyon F, Carlet J (1996) Bacteremia and severe sepsis in adults: a multicenter prospective survey on ICUs and wards of 24 hospitals. Am J Respir Crit Care Med 154: 617–624
Spencer RC (1996) Definitions of nosocomial infections. Surveillance of nosocomial infections. Bailleres Clin Infect Dis 237–252
Garner JS, Favero MS (1986) CDC guidelines for the prevention and control of nosocomial infections. Guideline for handwashing and hospital environmental control, 1985. Am J Infect Control 14: 110–126
Jarvis WR (1994) Handwashing - the Semmelweis lesson forgotten? Lancet 344: 13111312
Ewig S, Torres A, El-Ebiary M et al (1999) Bacterial colonization patterns in mechanically ventilated patients with traumatic and medical head injury. Incidence, risk factors, and association with ventilator-associated pneumonia. Am J Respir Crit Care Med 159: 188–198
Fagon J-Y, Chastre J, Domart Y et al (1989) Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 139: 877–844
Rayner BL, Willcox PA (1988) Community-acquired bacteraemia: a prospective survey of 239 cases. Q J Med 69: 907–919
Murray AE, Chambers JJ, van Saene HKF (1998) Infections in patients requiring ventilation in intensive care: application of a new classification. Clin Microbiol Infect 4: 94–99
Silvestri L, Monti-Bragadin C, Milanese M et al (1999) Are ICU infections really nosocomial? A prospective observational cohort study in mechanically ventilated patients. J Hosp Infect 42: 125–133
Silvestri L, Sarginson RE, Hughes Jet al (2000) Most nosocomial pneumonia are not due to nosocomial bacteria in ventilated patients - Prospective evaluation of the accuracy of the 48h time cut-off using carriage as gold standard. Chest (submitted)
van Saene HKF, Silvestri L, Baines P (1998) Definitions. In: van Saene HKF, Silvestri L, de la Cal MA (eds) Infection control in the intensive care unit. Springer-Verlag, Milano, pp 1–8
Damjanovic V, van Saene HKF, Weindling AM et al (1994) The multiple value of surveillance cultures: an alternative view. J Hosp Infect 28: 71–74
Leonard EM, van Saene HKF, Stoutenbeek CP et al (1990) An intrinsic pathogenicity index for micro-organisms causing infection in a neonatal surgical unit. Microbiol Ecol Health Dis 3: 151–157
Morar P, Singh V, Jones AS et al (1998) Impact of tracheotomy on colonization and infection of lower airways in children requiring long-term ventilation: a prospective observational cohort study. Chest 113: 77–85
van Saene HKF, Tometzki A, Fairclough SJ et al (1999) Carriage, colonisation and infection. In: Bion J (ed) Intensive care medicine. BMJ Books, London, pp 272–285
Nathens AB, Marshall JC (1999) Selective decontamination of the digestive tract in surgical patients. A systematic review of the evidence. Arch Surg 134: 170–176
Hammond JMJ, Potgieter PD (1995) Long-term effects of selective decontamination on antimicrobial resistance. Crit Care Med 23: 637–645
Stoutenbeek CP, van Saene HKF, Zandstra DF (1987) The effect of oral non-absorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit. J Antimicrob Chemother 19: 513–520
Tetteroo GWM, Wangevoort JHT, Bruining HA (1994) Bacteriology of selective decontamination: efficacy and rebound colonization. J Antimicrob Chemother 34: 139–148
Saunders N, Hammond JMJ, Potgieter PD et al (1994) Microbiological surveillance during selective decontamination of the digestive tract ( SDD ). J Antimicrob Chemother 34: 529–544
Brun-Bruisson C, Legrand P, Rauss A et al (1989) Intestinal decontamination for control of nosocomial multi-resistant Gram-negative bacilli. Ann Intern Med 110: 873–881
Taylor ME, Oppenheim BA (1991) Selective decontamination of gastrointestinal tract as an infection control measure. J Hosp Infect 71: 271–278
van Saene HKF, Stoutenbeek CP, Miranda DR, Zandstra DF (1983) A novel approach to infection control in the intensive care unit. Acta Anesth Belg 34: 193–208
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Italia, Milano
About this paper
Cite this paper
Silvestri, L., Fontana, F., van Saene, H.K.F., Petros, A.J. (2001). Microbiology for the Critically Ill Patient Receiving Selective Decontamination of the Digestive Tract. In: van Saene, H.K.F., Sganga, G., Silvestri, L. (eds) Infection in the Critically Ill: an Ongoing Challenge. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2242-3_8
Download citation
DOI: https://doi.org/10.1007/978-88-470-2242-3_8
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0138-1
Online ISBN: 978-88-470-2242-3
eBook Packages: Springer Book Archive