Early goal-directed therapy prevents organ failure and mortality in severe sepsis and septic shock

  • E. Rivers
  • B. Nguyen
  • S. Havstad
Conference paper


The systemic inflammatory response syndrome can be self-limited or progress to severe sepsis and septic shock [1]. Along this continuum, circulatory abnormalities lead to an imbalance between systemic oxygen delivery and demands or global tissue hypoxia [2]. As a modulator to serious illness, global tissue hypoxia is a sentinel development preceding multiple system organ failure and death [2]. This transition to serious illness occurs during the proverbial “golden-hour” when definitive recognition and treatment provide maximum outcome benefit. However, these “golden-hours” can elapse in the emergency department [3], hospital ward [4], and even in the intensive care unit [5].


Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Intensive Care Unit Admission Central Venous Pressure 
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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • E. Rivers
  • B. Nguyen
  • S. Havstad

There are no affiliations available

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