Abstract
A common clinical problem in neuroradiology is the differentiation of recurrent malignant glioma from radiation necrosis. Frequently, patients present one to two years after surgery and radiation therapy with large intracranial lesions. The lesions enhance with intravenous contrast material and have associated vasogenic edema. It is virtually impossible to distinguish recurrent tumor from radiation necrosis based solely on the imaging characteristics. Previous studies using positron emission tomography (PET) and fluorodeoxyglucose (FDG) have been successful in differentiating these entities based on variations in metabolic activity [1–3].
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References
DiChiro G, Oldfield E, Wright DC, DeMichele D, Katz DA, Patronas NJ, Doppman JL, Larson SM, Ito M, Kufta CV (1988) Cerebral Necrosis After Radiotherapy and/or Intraarterial Chemotherapy for Brain Tumors: PET and Neuropathologic Studies. Am J Roentgenol 150: 189–197
DiChiro G, DeLa Paz RL, Brooks RA, et al (1982) Glucose utilization of cerebral gliomas measured by 18F-fluorodeoxyglucose and PET. Neurology 32: 1323–1329
Mazziotta JC (1991) The Continuing Challenge of Primary Brain Tumor Management: The Contribution of Positron Emission Tomography. Ann Neurology 29: 345–346
Ito M, Lammertsma AA, Wise RJS, Bernardi S, Frackowiak RSJ, Heather JD, McKenzie CG, Thomas DGT, Jones T (1995) Measurement of Regional Cerebral Blood Flow and Oxygen Utilisation in Patients with Cerebral Tumours Using 150 and Positron Emission Tomography: Analytical Techniques and Preliminary Results Proocedings of the Society of Magnetic Resonance in Medicine, p. 394
Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1990) Perfusion Imaging with NMR Contrast Agents. Magn Reson Med 14: 249–265
Rosen BR, Belliveau JW, Buchbinder BR, McKinstry RC, Porkka LM, Kennedy DN, Neuder MS, Fisel CR, Aronen HJ, Kwong KK, Weisskoff RM, Cohen MS, Brady TJ (1991) Contrast Agents and Cerebral Hemodynamics. Magn Reson Med 19: 285–292
Maeda M, Itoh S, Kimura H, Iwasaki T, Hayashi N, Yamamoto K, Ishii Y, Kubota T (in press) Tumor Vascularity in the Brain: Evaluation with Dynamic Susceptibility-Contrast MR Imaging. Magn Reson Med
Aronen HJ, Gazit IE, Louis DN, Buchbinder BR, Pardo FS, Weisskoff RM, Harsh GR, Cosgrove GR, Halpern EF, Hochberg FH, Rosen BR (1994) Cerebral Blood Volume Maps of Gliomas: Comparison with Tumor Grade and Histologic Findings. Radiology 191: 41–51
Rosen BR, Aronen HJ, Kwong KK, Belliveau JW, Hamberg LM, Fordham J (1993) Advances in Clinical Neuroimaging: Functional MR Imaging Techniques. RadioGraphics 13: 889–896
Rempp KA, Brix G, Wenz F, Becker CR, Gückel F, Lorenz WJ (1993) Quantification of Regional Cerebral Blood Flow and Volume with Dynamic Susceptibility Contrast-enhanced MR Imaging. Radiology 193: 637–641
Roberts TPL, Kucharczyk J, Cox I, Moseley ME, Prayer L, Dillon W, Bleyl K, Harnish P (1994) Sprodiamide-Injection-Enhanced Magnetic Resonance Imaging of Cerebral Perfusion. Invest Radiol 29: S24 - S26
Tzika AA, Massoth RJ, Ball, Jr WS, Majumdar S, Dunn RS, Kirks DR (1993) Cerebral Perfusion in Children: Detection with Dynamic Contrast-enhanced T2*-weighted MR Images. Radiology 187: 449–458
Bahn MM (1995) A Single-Step Method for Estimation of Local Cerebral Blood Volume from Susceptibility Contrast MRI Images. Magn Reson Med 33: 309–317
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© 1996 Springer-Verlag Italia, Milano
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Turski, P., Mock, B., Baker, E., Terae, S., Bahn, M. (1996). Tumor Viability Assessed by Cerebral Blood Volume Measurements. In: Pavone, P., Rossi, P. (eds) Functional MRI. Syllabus. Springer, Milano. https://doi.org/10.1007/978-88-470-2194-5_6
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DOI: https://doi.org/10.1007/978-88-470-2194-5_6
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