Abstract
Historically, homozygous beta-thalassemia major has been associated with marked osseous changes, originally described by Cooley et al. in 1927 [1]. The pathogenesis of the abnormal bony changes has been ascribed to the underlying massive ineffective erythropoiesis and erythroid expansion of medullary bone, and the subsequent thinning of cortical bone, as well as metabolic and endocrine dysfunction secondary to hemochromatosis [2, 3]. Concurrent osteopenia results in frequent pathological fractures and premature epiphyseal fusion [4, 5].
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Giardina, P.J. et al. (1995). Abnormal Bone Metabolism in Thalassemia. In: Andò, S., Brancati, C. (eds) Endocrine Disorders in Thalassemia. Springer, Milano. https://doi.org/10.1007/978-88-470-2183-9_6
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DOI: https://doi.org/10.1007/978-88-470-2183-9_6
Publisher Name: Springer, Milano
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