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Myocardial Catecholamines and Inotropic Response in Heart Muscle Disease

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Advances in Cardiomyopathies

Abstract

It is widely accepted that both humoral and tissue alterations of sympathetic nervous system activity exist in various heart muscle diseases, including in idiopathic dilated (IDC) and hypertrophic cardiomyopathy (HCM). In particular, there is increasing evidence that myocardial catecholamines may be important determinants of natural history, pathophysiology and prognosis of these patients.

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References

  1. Schofer J, Spielmann R, Schuchert A, Weber K, Schluter M (1988) Iodine-123 meta-iodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 12:1252–1258

    Article  PubMed  CAS  Google Scholar 

  2. Regitz V, Fleck E (1992) Myocardial adenine nucleotide concentrations and myocardial norepinephrine content in patients with heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol 69:1574–1580

    Article  PubMed  CAS  Google Scholar 

  3. Regitz V, Leuchs B, Bossaller C, Sehested J, Rappolder M, Fleck E (1991) Myocardial catecholamine concentrations in dilated cardiomyopathy and heart failure of different origins. Eur Heart J 12 [Suppl. D]:171–174

    Article  PubMed  Google Scholar 

  4. De Maria R, Accinni R, Baroldi G, Repossini A, Garino-Cannia G, Caroli A, Vago T, Bevilacqua M, Pellegrini A (1990) Catecholamines, beta receptors and morphology in dilated cardiomyopathy: a preliminary report. In: Baroldi G, Camerini F, Goodwin JF (eds) Advances in cardiomyopathies. Springer, Berlin Heidelberg New York, pp 257–265

    Chapter  Google Scholar 

  5. Brush JE Jr, Eisenhofer G, Garty M, Stull R, Maron BJ, Cannon R (1989) Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy. Circulation 79:836–844

    Article  PubMed  Google Scholar 

  6. Seferovič PM, Stepanovič S, Maksimovič R, et al. (1997) Long-term prognosis in hypertrophie and idiopathic dilated cardiomyopathy: the role of myocardial catecholamine. Eur Heart J 18 [Suppl. A]:P3725

    Google Scholar 

  7. Correa-Araujo R, Oliveira JS, Ricciardi-Cruz A (1991) Cardiac levels of norepinephrine, dopamine, serotonin and histamine in Chagas’ disease. Int J Cardiol 31:329–36

    Article  PubMed  CAS  Google Scholar 

  8. Da Prada M, Zürcher G (1976) Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci 19:1161–1174

    Article  PubMed  Google Scholar 

  9. Weise VK, Kopin IJ (1976) Assay of catecholamines in human plasma. Studies of a single isotope radioenzymatic technique. Life Sci 19:1673–1686

    CAS  Google Scholar 

  10. Pauler JD, Johnson GA (1977) Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. Life Sci 21:625–636

    Article  Google Scholar 

  11. Seferovič PM, Stepanovič S, Maksimovič R et al. (1995) Myocardial catecholamine in primary heart muscle diseases: Fact or fancy? Eur Heart J 16 [Suppl. O]:124–127

    Article  PubMed  Google Scholar 

  12. Seferovič PM, Stepanovič S, Maksimovič R, et al. (1997) Does myocardial catecholamine concentration reflect left ventricular function in heart muscle disease? J Am Coll Cardiol:796

    Google Scholar 

  13. Gilbert EM, Olsen SL, Renlund DG, Bristow MR (1993) Beta-adrenergic receptor regulation and left ventricular function in idiopathic dilated cardiomyopathy. Am J Cardiol 71:23–29

    Article  Google Scholar 

  14. Himura Y, Feiten SY, Kashiki M, Lewandowski TJ, Delehanty JM, Liang CS (1993) Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation 88:1299–1309

    Article  PubMed  CAS  Google Scholar 

  15. Perloff JK (1981) Pathogenesis of hypertrophie cardiomyopathy: hypothesis and speculations. Am Heart J 101:219–220

    Article  PubMed  CAS  Google Scholar 

  16. Dargie H, Boschetti E, Reid J, Goodwin JF (1980) Autonomie function in hypertrophie cardiomyopathy. Circulation 2 [Suppl. III]:III–301

    Google Scholar 

  17. Sugishita Y, Iida K, Matsuda M, et al. (1983) Plasma norepinephrine concentration during exercise in patients with different types of hypertrophie cardiomyopathy. Annual Report of the Idiopathic Cardiomyopathy Research Committee, The Ministry of Health and Welfare of Japan Publication, Tokyo, pp 168–171

    Google Scholar 

  18. Maisel AS, Wright M, Wilner KD, Ziegler MG (1988) Norepinephrine kinetics in hypertrophie cardiomyopathy. In: Toshima H, Maron BJ (eds) Hypertrophic Cardiomyopathy. University of Tokyo Press, Tokyo, pp 129–139

    Google Scholar 

  19. Haneda T, Miura Y, Miyazawa K, et al. (1978) Plasma norepinephrine concentration in the coronary sinus in cardiomyopathies. Cath Cardiovasc Diag 4:399–405

    Article  CAS  Google Scholar 

  20. Toshima H, Koga Y (1988) Norepinephrine kinetics in hypertrophie cardiomyopathy. In: Toshima H, Maron BJ (eds) Hypertrophic Cardiomyopathy. University of Tokyo Press, Tokyo, pp 141–153

    Google Scholar 

  21. Pearse AGE (1964) The histochemistry and electron microscopy of obstructive cardiomyopathy. In: Wolstenhome GEW, O’Connor M (eds) Cardiomyopathies. G&A Churchill, London, pp 132–164

    Chapter  Google Scholar 

  22. McCallister BD, Brown AL (1967) A fine-structure study of idiopathic hypertrophie subaortic stenosis. Am J Cardiol 19:142–154

    Article  Google Scholar 

  23. Van Noorden S, Olsen EGJ, Pearse AGE (1971) Hypertrophic obstructive cardiomyopathy, a histological, histochemical and ultrastructural study of biopsy material. Cardiovasc Res 5:118–131

    Article  PubMed  Google Scholar 

  24. Kawai C, Yui Y, Hoshono T, Sasayama S, Matsumori A (1983) Myocardial catecholamine in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study. J Am Coll Cardiol 2:834–840

    Article  PubMed  CAS  Google Scholar 

  25. Beau SL, Saffitz JE (1994) Transmural heterogeneity of norepinephrine uptake in failing human hearts. J Am Coll Cardiol 23:579–585

    Article  PubMed  CAS  Google Scholar 

  26. Schofer J, Tews A, Langes K, Bleifeld W, Reimitz PE, Mathey DG (1987) Relationship between myocardial norepinephrine content and left ventricular function — an endomyocardial biopsy study. Eur Heart J 8:748–753

    Article  PubMed  CAS  Google Scholar 

  27. Anderson FL, Port D, Reid BB, Larrabee P, Hanson G, Bristow MR (1992) Myocardial catecholamine and neuropeptide Y depletion in failing ventricles of patients with idiopathic dilated cardiomyopathy. Correlation with beta adrenergic receptor downregulation. Circulation 85:46–53

    CAS  Google Scholar 

  28. Schofer J, Bleifeld W (1987) Sympathetic activity in idiopathic dilated cardiomyopathy. Influence of captopril and hydralazine. Cardiovasc Drugs Ther 1:177–181

    Article  CAS  Google Scholar 

  29. Regitz V, Bossaller C, Strasser R, Schuler S, Hetzer R, Fleck E (1990) Myocardial catecholamine content after heart transplantation. Circulation 82:620–623

    Article  PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Italia

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Seferovič, P.M. et al. (1998). Myocardial Catecholamines and Inotropic Response in Heart Muscle Disease. In: Camerini, F., Gavazzi, A., De Maria, R. (eds) Advances in Cardiomyopathies. Springer, Milano. https://doi.org/10.1007/978-88-470-2155-6_19

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  • DOI: https://doi.org/10.1007/978-88-470-2155-6_19

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2181-5

  • Online ISBN: 978-88-470-2155-6

  • eBook Packages: Springer Book Archive

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