Skip to main content
SpringerLink
Log in

Demyelinating Diseases

  • Chapter
Diseases of the Brain, Head and Neck, Spine

  • 390 Accesses

Abstract

The spectrum of white matter diseases is broad, with conditions ranging from the relatively benign to the progressively debilitating to the rapidly fulminant and fatal. While a specific diagnosis based on the imaging appearance alone is often not possible because of considerable overlap among the diseases, magnetic resonance imaging (MRI) remains ideal for the detection of many of these diseases because of its sensitivity in identifying free water within the normally myelinated white matter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hauser SL (1994) Multiple sclerosis and other demyelinating disease. In: Isselbacher KJ, Graunwald E, Wilson JD, Martin JD, Fauci AS, Kasper DL (eds) Harrison’s principle of internal medicine. McGraw-Hill, New York, pp 2287–2295

    Google Scholar 

  2. Farlow MR, Bonine JM (1993) Clinical and neuropathological features of multiple sclerosis. Neuroradiol Clin N Am 3:213–228

    Google Scholar 

  3. Trobe JD (1994) High-dose corticosteroid regimen retards development of multiple sclerosis in optic neuritis treatment trial. Arch Ophthalmol 112:35–36

    Article  PubMed  CAS  Google Scholar 

  4. McDonald WI, Compston A, Edan G, Goodkin D, Hartung H-P, Lublin FD et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 50:121–127

    Article  PubMed  CAS  Google Scholar 

  5. Grossman RI, McGowan JC (1998) Perspective of multiple sclerosis. AJNR Am J Neuroradiol 19:1251–1265

    PubMed  CAS  Google Scholar 

  6. Niebler G, Harris T, Davis T, Roos K (1992) Fulminant multiple sclerosis. AJNR Am J Neuroradiol 13:1547–1551

    PubMed  CAS  Google Scholar 

  7. Gharagozloo AM, Poe LB, Collins GH (1994) Antemortem diagnosis of Balo concentric sclerosis: correlative MR imaging and pathologic features. Radiology 191:817–819

    PubMed  CAS  Google Scholar 

  8. Barkhof F, Scheltens P, Frequin STFM, Nauta JJP, Tas MW, Valk J et al (1992) Relapsing-remitting multiple sclerosis: sequential enhanced MR imaging vs. clinical findings in determining disease activity. AJR Am J Roentgenol 159:1041–1047

    PubMed  CAS  Google Scholar 

  9. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M (1991) Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 180:467–474

    PubMed  CAS  Google Scholar 

  10. Horowitz AL, Kaplan RD, Grewe G, White RT, Salberg LM (1989) The ovoid lesion: a new MR observation in patients with multiple sclerosis. AJNR Am J Neuroradiol 10:303–305

    PubMed  CAS  Google Scholar 

  11. Gean-Marton AD, Vezina LG, Marton KI, Stimac GK, Peyster RG, Taveras JM et al (1991) Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis. Radiology 180:215–221

    PubMed  CAS  Google Scholar 

  12. Hashemi RH, Bradley WG Jr, Chen DY, Jordan JE, Queralt JA, Cheng AE et al (1995) Suspected multiple sclerosis: MR imaging with a thin-section fast FLAIR pulse sequence. Radiology 196:505–510

    PubMed  CAS  Google Scholar 

  13. Dagher AP, Smirniotopoulous JG (1996) Tumefactive demyelinating lesions. Neuroradiology 38:560–565

    Article  PubMed  CAS  Google Scholar 

  14. Grossman RI, Gonzalez-Scarano F, Atlas SW, Galetta S, Silberberg DH (1986) Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 161:721–725

    PubMed  CAS  Google Scholar 

  15. Ge Y, Grossman RI, Udupa JK, Wei L, Mannon LJ, Polansky M et al (2000) Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis. Radiology 214:665–670

    PubMed  CAS  Google Scholar 

  16. Dietemann JL, Beigelman C, Rumbach L, Vogue M, Tajahmady T, Faubert C et al (1988) Multiple sclerosis and corpus callosum atrophy: relationship of MRI findings to clinical data. Neuroradiology 30:478–480

    Article  PubMed  CAS  Google Scholar 

  17. Mehta RC, Pike GB, Enzmann DR (1996) Measure of magnetization transfer in multiple sclerosis demyelinating plaques, white matter ischemic lesions, and edema. AJNR Am J Neuroradiol 17:1051–1055

    PubMed  CAS  Google Scholar 

  18. Grossman RI, Lenkinski RE, Ramer KN, Gonzalez-Scarano F, Cohen JA (1992) MR proton spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol 13:1535–1543

    PubMed  CAS  Google Scholar 

  19. Falini A, Calabrese G, Filippi M, Origgi D, Lipari S, Colombo B et al (1998) Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. AJNR Am J Neuroradiol 19:223–229

    PubMed  CAS  Google Scholar 

  20. Singh S, Alexander M, Korah IP (1999) Acute disseminated encephalomyelitis: MR imaging features. AJR Am J Roentgenol 173:1101–1107

    PubMed  CAS  Google Scholar 

  21. Whiteman M, Post MJD, Berger JR, Tate LG, Bell MD, Limonte LP (1993) Progressive multifocal leukoencephalopathy in 47 HlV-seropositive patients: neuroimaging with clinical and pathologic correlation. Radiology 187:233–240

    PubMed  CAS  Google Scholar 

  22. McArthur JC, Sacktor N, Seines O (1999) Human immunodeficiency virus-associated dementia. Semin Neurol 19:105–111

    Article  Google Scholar 

  23. Izquierdo G, Quesada MA, Chacon J, Martel J (1992) Neuroradiologic abnormalities in Marchiafava-Bignami disease of benign evolution. Eur J Radiol 15:71–74

    Article  PubMed  CAS  Google Scholar 

  24. Miller GM, Baker HL, Okazaki H, Whisnant JP (1988) Central pontine myelinolysis and its imitators: MR findings. Radiology 168:795–802

    PubMed  CAS  Google Scholar 

  25. Valk PE, Dillon WP (1991) Radiation injury of the brain. AJNR Am J Neuroradiol 12:45–62

    PubMed  CAS  Google Scholar 

  26. Chan Y, Leung S, King AD, Choi PH, Metreweli C (1999) Late radiation injury to the temporal lobes: morphologic evaluation at MR imaging. Radiology 213:800–807

    PubMed  CAS  Google Scholar 

  27. Davis P, Hoffman JJ, Pearl G, Braun I (1986) CT evaluation of effects of cranial radiation therapy in children. AJR Am J Roentgenol 147:587–592

    PubMed  CAS  Google Scholar 

  28. Post JD, Beauchamp NJ (1998) Reversible intracerebral pathologic entities mediated by vascular autoregulatory dysfunction. Radiographics 18:353–367

    Google Scholar 

  29. Yousry TA, Seelos K, Mayer M, Bruning R, Uttner I, Dichgans M et al (1999) Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). AJNR Am J Neuroradiol 20:91–100

    PubMed  CAS  Google Scholar 

  30. Kendall BE (1992) Disorders of lysosomes, peroxisomes, and mitochondria. AJNR Am J Neuroradiol 13:621–653

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA

    K. K. Koeller

  2. Premier Health Imaging, Chicago, IL, USA

    R. G. Ramsey

Authors
  1. K. K. Koeller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. G. Ramsey
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsspital Nuklearmedizin, 8091, Zürich, Switzerland

    G. K. von Schulthess

  2. Kantonsspital Institut für Radiologie, 8401, Winterthur, Switzerland

    Ch. L. Zollikofer

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Italia

About this chapter

Cite this chapter

Koeller, K.K., Ramsey, R.G. (2004). Demyelinating Diseases. In: von Schulthess, G.K., Zollikofer, C.L. (eds) Diseases of the Brain, Head and Neck, Spine. Springer, Milano. https://doi.org/10.1007/978-88-470-2131-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2131-0_8

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0251-7

  • Online ISBN: 978-88-470-2131-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation