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The Grey Matter Component of MS Pathology: Magnetization Transfer and Diffusion-Weighted Imaging

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Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

Part of the book series: Topics in Neuroscience ((TOPNEURO))

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Abstract

The classical view of multiple sclerosis (MS) as a chronic inflammatory disease affecting the white matter (WM) of the central nervous system (CNS) has been recently challenged by pathological studies and by the extensive application of modern magnetic resonance imaging (MRI)-based techniques, including magnetization transfer (MT) MRI and diffusion-weighted (DW) MRI. These techniques have overcome some of the limitations of conventional MRI, such as its poor specificity to the heterogeneous pathological substrates of the disease, and have demonstrated that: (1) axonal pathology in macroscopic brain lesions and in normal-appearing brain tissue is an important feature of MS from its earliest phase; (2) grey matter (GM) is not spared by the pathological process in MS; and (3) brain plasticity might contribute to clinical recovery and the maintenance of a normal level of function in the presence of MS-related irreversible tissue loss.

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Authors
  1. M. A. Rocca
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  2. M. Filippi
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Editor information

Editors and Affiliations

  1. Department of Neurology Scientific Institute, University Ospedale San Raffaele, Milan, Italy

    Giancarlo Comi

  2. Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Massimo Filippi  & Marco Rovaris  & 

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© 2004 Springer-Verlag Italia

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Rocca, M.A., Filippi, M. (2004). The Grey Matter Component of MS Pathology: Magnetization Transfer and Diffusion-Weighted Imaging. In: Comi, G., Filippi, M., Rovaris, M. (eds) Normal-appearing White and Grey Matter Damage in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2127-3_11

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  • DOI: https://doi.org/10.1007/978-88-470-2127-3_11

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2175-4

  • Online ISBN: 978-88-470-2127-3

  • eBook Packages: Springer Book Archive

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