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Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E. pp 287–298Cite as

How Permissive Should Hypercapnia Be?

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Abstract

The alteration of gas exchange is one of the main characteristics of acute respiratory distress syndrome (ARDS), and the first approaches aim to normalize blood gas values. Large tidal volumes and high peak inspiratory pressure were used, restricted only for the risk of pneumothorax and hemodynamic impairment. An evolving body of experimental studies, conducted over the last decades, have demonstrated ventilator-induced lung injury (VILI). They also demonstrated that mechanical ventilation with high peak inspiratory pressure induces a “dose”-dependent exudative pulmonary edema, correlated more to high tidal volume excursion than to high inspiratory pressure [1, 2].

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Author information

Authors and Affiliations

  1. Department of Anaesthesia and Intensive Care, Naples University “Federico II”, Naples, Italy

    G. Servillo & R. Tufano

  2. Department of Surgical, Anaesthesiological and Emergency Sciences, Naples University “Federico II”, Naples, Italy

    L. D’amato

Authors
  1. G. Servillo
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  2. L. D’amato
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  3. R. Tufano
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Editor information

Editors and Affiliations

  1. Department of Clinical Sciences Section of Anaesthesia, Intensive Care and Pain Clinic, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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© 2002 Springer-Verlag Italia

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Servillo, G., D’amato, L., Tufano, R. (2002). How Permissive Should Hypercapnia Be?. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2099-3_27

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  • DOI: https://doi.org/10.1007/978-88-470-2099-3_27

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0176-3

  • Online ISBN: 978-88-470-2099-3

  • eBook Packages: Springer Book Archive

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